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New Perspectives in Parkinson’s Disease

  • Conference paper
Modification of Cell to Cell Signals During Normal and Pathological Aging

Part of the book series: NATO ASI Series ((ASIH,volume 9))

Abstract

A working hypothesis of the aetiology of Parkinson’s disease has been postulated (Calne and Langston, 1983). It was proposed that some environmental factor causes selective damage to the nigrostriatal dopaminergic system. When this insult is followed by the gradual age related decline in the population of dopaminergic cells, eventually the system decompensates and clinical parkinsonsism becomes manifest perhaps many years after the initial damage had occurred. This theory recieves support from recent studies of the amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam and of parkinsonism induced by l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The combination of selective environmental damage followed by age related attrition may also be important in the aetiology of Alzheimer’s disease and amyotrophic lateral sclerosis (ALS).

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Author information

Authors and Affiliations

  1. Division of Neurology Department of Medicine, Health Sciences Centre Hospital University of British Columbia, Vancouver, B.C., V6T 1W5, Canada

    R. F. Peppard & D. B. Calne

Authors
  1. R. F. Peppard
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  2. D. B. Calne
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Editor information

Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milano, Via A. del Sarto, 21, 20129, Milano, Italy

    Stefano Govoni  & Fiorenzo Battaini  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Peppard, R.F., Calne, D.B. (1987). New Perspectives in Parkinson’s Disease. In: Govoni, S., Battaini, F. (eds) Modification of Cell to Cell Signals During Normal and Pathological Aging. NATO ASI Series, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72729-0_18

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  • DOI: https://doi.org/10.1007/978-3-642-72729-0_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72731-3

  • Online ISBN: 978-3-642-72729-0

  • eBook Packages: Springer Book Archive

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