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The Role of Mitochondrial Cytochrome c in Electron Transport

  • Chapter
Cytochromes c

Part of the book series: Springer Series in Molecular Biology ((SSMOL))

Abstract

The location and role of mitochondrial cytochrome c are represented diagrammatically in Fig. 2.1, a scheme which can be applied in a broader way to many bacterial systems (Chap. 3). The intermembrane location was established by several lines of evidence (reviewed in Nicholls 1974) but the means by which cytochrome c conducts electrons between its membrane reductase and oxidase remains controversial and forms the main subject of this chapter. Also controversial is the relative importance of the reactions of cytochrome c with soluble redox systems. This subject will be considered in Section 2.8.

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References

  • Abe K, Kimura S, Kizawa R, Anan FK, Sugita Y (1985) Amino acid sequences of cytochrome b5 from human, porcine and bovine erythrocytes and comparison with liver microsomal cytochrome b5. J Biochem 97:1659–1668

    PubMed  CAS  Google Scholar 

  • Ahmed AJ, Smith HT, Smith MB, Millet FS (1978) The effect of specific lysine modification on the reduction of cytochrome c by succinate cytochrome c reductase. Biochemistry 17:2479–2483

    Article  PubMed  CAS  Google Scholar 

  • Andersson T, Thulin E, Forsen S (1979) Ion-binding to cytochrome c studied by nuclear magnetic quadrupole relaxation. Biochemistry 18:2487–2493

    Article  PubMed  CAS  Google Scholar 

  • Antalis TM, Palmer G (1982) Kinetic characterisation of the interaction between cytochrome c oxidase and cytochrome c. J Biol Chem 257:6194–6206

    PubMed  CAS  Google Scholar 

  • Appleby CA, Morton RK (1959) Purification of cytochrome b2. Biochem J 71:492–499

    PubMed  CAS  Google Scholar 

  • Argos P, Mathews FS (1975) The structure of cytochrome b5 at 2.8 Å resolution. J Biol Chem 250:747–751

    PubMed  CAS  Google Scholar 

  • Azzi A, Bill K, Broger C (1982) Affinity chromatography purification of cytochrome c binding enzymes. Proc Natl Acad Sci USA 79:2447–2450

    Article  PubMed  CAS  Google Scholar 

  • Barlow GH, Margoliash E (1966) Electrophoretic behaviour of mammalian-type cytochromes c. J Biol Chem 241:1473–1477

    PubMed  CAS  Google Scholar 

  • Baudras A (1971) Pure lactate: cytochrome c oxidoreductase of the yeast Hansenula anomala. Biochimie 53:929–933

    Article  PubMed  CAS  Google Scholar 

  • Baudras A, Capeillere-Blandin C, Iwatsubo M, Labeyrie F (1972) The formation of a stable complex between cytochrome b2 and cytochrome c and study of its role in the overall electron transfer by rapid kinetics. In: Akeson A, Ehrenberg A (eds) Structure and function of oxidation reduction enzymes. Pergamon, New York, pp 273–290

    Google Scholar 

  • Bechtold R, Bosshard HR (1985) Structure of an electron transfer complex — chemical modification of carboxyl groups of cytochrome c peroxidase in the presence or absence of cytochrome c. J Biol Chem 260:5191–5200

    PubMed  CAS  Google Scholar 

  • Beetlestone J (1960) The oxidation of cytochrome c by cytochrome c peroxidase. Arch Biochem Biophys 89:35–40

    Article  PubMed  CAS  Google Scholar 

  • Bernardi P, Azzone GF (1981) Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes. J Biol Chem 256:7187–7192

    PubMed  CAS  Google Scholar 

  • Bill K, Azzi A (1984) Interaction of reduced and oxidised cytochrome c with the mitochondrial cytochrome c oxidase and bc1-complex. Biochem Biophys Res Commun 120:124–130

    Article  PubMed  CAS  Google Scholar 

  • Birchmeier W, Kohler CE, Schatz G (1976) Affinity labelling of yeast cytochrome oxidase by modified yeast cytochrome c. Proc Natl Acad Sci USA 73:4334–4338

    Article  PubMed  CAS  Google Scholar 

  • Bisson R, Capaldi RA (1981) Binding of arylazido cytochrome c to yeast cytochrome c peroxidase. J Biol Chem 256:4362–4367

    PubMed  CAS  Google Scholar 

  • Bisson R, Montecucco C (1982) Different polypeptides of bovine heart cytochrome c oxidase are in contact with cytochrome c. FEBS Lett 150:49–53

    Article  PubMed  CAS  Google Scholar 

  • Bisson R, Gutweniger H, Azzi A (1978a) Photoaffinity labelling of yeast cytochrome oxidase with arylazido cytochrome c derivatives. FEBS Lett 92:219–222

    Article  PubMed  CAS  Google Scholar 

  • Bisson R, Azzi A, Gutweniger H, Collona R, Montecucco C, Zanotti A (1978b) Interaction of cytochrome c with cytochrome oxidase. J Biol Chem 253:1874–1880

    PubMed  CAS  Google Scholar 

  • Bisson R, Montecucco C, Gutweniger H, Azzi A (1979) Hydrophobic labelling of bovine heart cytochrome c oxidase with an azidophosphatidyl choline. Biochem Soc Trans 7:156–160

    PubMed  CAS  Google Scholar 

  • Bisson R, Jacobs B, Capaldi RA (1980) Binding of arylazido cytochrome c derivatives to beef heart cytochrome c oxidase — cross-linking in the high and low affinity sites. Biochemistry 19:4173–4178

    Article  PubMed  CAS  Google Scholar 

  • Bisson R, Steffens GCM, Capaldi RA, Buse G (1982) Mapping of the cytochrome c binding site on cytochrome oxidase. FEBS Lett. 144:359–363

    Article  PubMed  CAS  Google Scholar 

  • Bolli R, Nalecz KA, Azzi A (1985a) The aggregation state of bovine heart oxidase and its kinetics in monomeric and dimeric form. Arch Biochem Biophys 240:102–116

    Article  PubMed  CAS  Google Scholar 

  • Bolli R, Nalecz KA, Azzi A (1985b) The interconversion between monomeric and dimeric bovine heart cytochrome c oxidase. Biochimie 67:119–128

    Article  PubMed  CAS  Google Scholar 

  • Bosshard HR, Zurrer M, Schagger H, Jagow G von (1979) Binding of cytochrome c to the cytochrome bc1 complex (complex III) and its subunits, cytochrome c1 and b. Biochem Biophys Res Commun 89:250–258

    Article  PubMed  CAS  Google Scholar 

  • Bosshard HR, Banziger J, Hasler T, Poulos TL (1984) The cytochrome c: cytochrome c peroxidase complex – the role of histidine residues. J Biol Chem 259:5683–5690

    PubMed  CAS  Google Scholar 

  • Boswell AP, McClune GJ, Moore GR, Williams RJP, Pettigrew GW, Inubishi T, Yonetani T, Harris DE (1980) NMR study of the interaction of cytochrome c with cytochrome c peroxidase. Biochem Soc Trans 8:637–638

    PubMed  CAS  Google Scholar 

  • Bowyer JR, Edwards CA, Trumpower BL (1981) Involvement of the iron-sulfur protein of the mitochondrial cytochrome bc1 complex in the oxidant-induced reduction of cytochrome b. FEBS Lett 126:93–97

    Article  PubMed  CAS  Google Scholar 

  • Brautigan DL, Ferguson-Miller S, Margoliash E (1978) Reaction with 4-chloro-3,5-dinitro benzoate and chromatographic separation of singly substituted cytochrome c derivatives. J Biol Chem 253:130–139

    PubMed  CAS  Google Scholar 

  • Briggs MM, Capaldi RA (1978) Cross-linking studies on a cytochrome c — cytochrome oxidase complex. Biochem Biophys Res Commun 80:553–559

    Article  PubMed  CAS  Google Scholar 

  • Broger C, Nalecz MJ, Azzi A (1980) Interaction of cytochrome with the cytochrome bc1 complex of the mitochondrial respiratory chain. Biochim Biophys Acta 592:519–529

    Article  PubMed  CAS  Google Scholar 

  • Broger C, Salardi S, Azzi A (1983) Interaction between isolated cytochrome c1 and cytochrome c. Eur J Biochem 131:349–352

    Article  PubMed  CAS  Google Scholar 

  • Brooks SPJ, Nicholls P (1982) Anion and ionic strength effects upon the oxidation of cytochrome c by cytochrome oxidase. Biochim Biophys Acta 680:33–43

    Article  PubMed  CAS  Google Scholar 

  • Brunori M, Wilson MT (1982) Cytochrome oxidase. Trends Biochem Sci 7:295–299

    Article  CAS  Google Scholar 

  • Buse G, Meinecke L, Bruch B (1985) The protein formula of beef heart cytochrome c oxidase. J Inorg Biochem 23:149–153

    Article  PubMed  CAS  Google Scholar 

  • Capaldi RA, Darley-Usmar V, Fuller S, Millet F (1982) Structural and functional features of the interaction of cytochrome c with Complex III and cytochrome oxidase. FEBS Lett 138:1–7

    Article  PubMed  CAS  Google Scholar 

  • Capaldi RA, Malatesta F, Darley-Usmar VM (1983) Structure of cytochrome oxidase. Biochim Biophys Acta 736:135–148

    Google Scholar 

  • Capeillere-Blandin C (1982) Transient kinetics of the one electron transfer reaction between reduced flavocytochrome b2 and oxidised cytochrome c. Eur J Biochem 128:533–542

    Article  PubMed  CAS  Google Scholar 

  • Capeillere-Blandin C, Bray RC, Iwatsubo M, Labeyrie F (1975) Flavocytochrome b2 — kinetic studies by absorbance and EPR spectroscopy of electron distribution among prosthetic groups. Eur J Biochem 54:549–566

    Article  PubMed  CAS  Google Scholar 

  • Casey RP, Broger C, Azzi A (1981) Structural studies on the cytochrome c oxidase proton pump using a spin-label probe. Biochim Biophys Acta 638:86–93

    Article  PubMed  CAS  Google Scholar 

  • Caughey WS, Wallace W J, Volpe JA, Yoshikawa S (1976) Cytochrome oxidase. In: Boyer PD (ed) The enzymes. Academic Press, London New York, pp 299–344

    Google Scholar 

  • Cerletti N, Schatz G (1979) Cytochrome c oxidase from bakers’ yeast — photolabelling of subunits exposed to the lipid bilayer. J Biol Chem 254:7746–7751

    PubMed  CAS  Google Scholar 

  • Chance B (1967) The reactivity of hemoproteins and cytochromes. Biochem J 103:1–18

    PubMed  CAS  Google Scholar 

  • Chance B (1974) The function of cytochrome c. Ann N Y Acad Sci 227:613–626

    Article  PubMed  CAS  Google Scholar 

  • Chance B, Schoener B, DeVault D (1964) Reaction velocity constants for electron transfer and transport reactions. In: King TE, Mason M, Morrison M (eds) Oxidases and related redox systems, vol 2. Wiley, New York London, pp 907–942

    Google Scholar 

  • Chance B, Erecinska M, Wilson DF, Dutton PL, Lee CP (1972) The function of cytochrome c in mitochondrial membranes. In: Akeson A, Ehrenberg A (eds) Structure and function of oxidation reduction enzymes. Pergamon, UK, pp 263–272

    Google Scholar 

  • Chiang YL, King TE (1979) Cytochrome c complexes. J Biol Chem 254:1845–1853

    PubMed  CAS  Google Scholar 

  • Chiang YL, Kaminsky LS, King TE (1976) A complex of cardiac cytochrome c1 and cytochrome c. J Biol Chem 251:29–36

    PubMed  CAS  Google Scholar 

  • Cohen HJ, Fridovich I (1971) Hepatic sulfite oxidase. J Biol Chem 246:359–373

    PubMed  CAS  Google Scholar 

  • Cohen HJ, Betcher-Land S, Kessler DL, Rajagopalan KV (1972) Hepatic sulfite oxidase — congruency in mitochondria of prosthetic groups and activity. J Biol Chem 247: 7759–7766

    PubMed  CAS  Google Scholar 

  • Corbley MJ, Azzi A (1984) Resolution of bovine heart cytochrome c oxidase into smaller complexes by controlled subunit denaturation. Eur J Biochem 139:535–540

    Article  PubMed  CAS  Google Scholar 

  • Cumsky MG, Trueblood CE, Poyton RO (1985) Two non-identical forms of subunit V are functional in yeast cytochrome c oxidase. Proc Natl Acad Sci USA 82:2235–2239

    Article  PubMed  CAS  Google Scholar 

  • Dailey HA, Strittmatter P (1979) Modification and identification of cytochrome b5 carboxyl groups involved in protein: protein interaction with cytochrome b5 reductase. J Biol Chem 254:5388–5396

    PubMed  CAS  Google Scholar 

  • Darley-Usmar VM, Georgevich G, Capaldi RA (1984) Reaction of thionitrobenzoate-modified yeast cytochrome c with monomeric and dimeric forms of beef heart cytochrome c oxidase. FEBS Lett 166:131–135

    Article  PubMed  CAS  Google Scholar 

  • Deatherage JF, Henderson R, Capaldi RA (1982) Three-dimensional structures of cytochrome c oxidase crystals in negative stain. J Mol Biol 158:487–499

    Article  PubMed  CAS  Google Scholar 

  • Dethmers JK, Ferguson-Miller S, Margoliash E (1979) Comparison of yeast and beef oxidases. J Biol Chem 254:11973–11981

    PubMed  CAS  Google Scholar 

  • Dickerson RE, Timkovich R (1975) Cytochromes c. In: Boyer PD (ed) The enzymes, 3rd edn, Vol 11. Academic Press, New York, pp 397–547

    Google Scholar 

  • Diggens RJ, Ragan CI (1982) Properties of UQ oxidase reconstituted from UQ cytochrome c reductase, cytochrome c and cytochrome oxidase. Biochem J 202:527–534

    PubMed  CAS  Google Scholar 

  • Dixon HBF (1976) Removal of a bound ligand from a macromolecule by gel-filtration. Biochem J 159:161–162

    CAS  Google Scholar 

  • Dowe RJ, Vitello LB, Erman JE (1984) Sedimentation equilibrium studies on the interaction between cytochrome c and cytochrome c peroxidase. Arch Biochem Biophys 232:566–573

    Article  PubMed  CAS  Google Scholar 

  • Dutton PL, Wilson DF, Lee CP (1970) Oxidation-reduction potentials of cytochromes in mitochondria. Biochemistry 9:5077–5082

    Article  PubMed  CAS  Google Scholar 

  • Eigen M, Hammes CG (1963) Elementary steps in enzyme reactions. Adv Enzymol 25:1–38

    PubMed  Google Scholar 

  • Eley CGS, Moore GR (1983) 1H-NMR investigation of the interaction between cytochrome c and cytochrome b5. Biochem J 215:11–21

    PubMed  CAS  Google Scholar 

  • Erecinska M, Vanderkooi JM (1978) Modification of cytochrome c. Methods Enzymol 53:165–181

    Article  PubMed  CAS  Google Scholar 

  • Erecinska M, Vanderkooi JM, Wilson DF (1975) Cytochrome c interaction with membranes — a photoaffinity labelled cytochrome. Arch Biochem Biophys 171:108–116

    Article  PubMed  CAS  Google Scholar 

  • Erecinska M, Davis JS, Wilson DF (1980) Interactions of cytochrome c with mitochondrial membranes. J Biol Chem 255:9653–9658

    PubMed  CAS  Google Scholar 

  • Erman JE, Vitello LB (1980) The binding of cytochrome c peroxidase and ferricytochrome c. J Biol Chem 255:6224–6227

    PubMed  CAS  Google Scholar 

  • Errede BJ, Kamen MD (1978) Comparative kinetic studies of cytochromes c in reactions with mitochondrial cytochrome c oxidase and reductase. Biochemistry 17:1015–1027

    Article  PubMed  CAS  Google Scholar 

  • Errede BJ, Kamen MD (1979) Mechanisms for the steady state kinetics of reaction of cytochrome c with mitochondrial cytochrome oxidase. In: King TE, Orii Y, Chance B, Okunuki K (eds) Cytochrome oxidase. Elsevier, Amsterdam, pp 269–280

    Google Scholar 

  • Errede BJ, Haight GP, Kamen MD (1976) Oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase. Proc Natl Acad Sci USA 73:113–117

    Article  PubMed  CAS  Google Scholar 

  • Falk KE, Jovall PA, Angstrom J (1981) NMR and EPR characterisation of 4-carboxy-2,6-dinitrophenyl lysine cytochromes c. Biochem J 193:1021–1024

    PubMed  CAS  Google Scholar 

  • Ferguson-Miller S, Brautigan DL, Margoliash E (1976) Correlation of the kinetics of electron transfer activity of various eukaryotic cytochromes c with binding to mitochondrial cytochrome oxidase. J Biol Chem 251:1104–1115

    PubMed  CAS  Google Scholar 

  • Ferguson-Miller S, Brautigan DL, Margoliash E (1978a) Definition of cytochrome c binding domains by chemical modification. J Biol Chem 253:149–159

    PubMed  CAS  Google Scholar 

  • Ferguson-Miller S, Brautigan DL, Margoliash E (1978b) The electron transfer function of cytochrome c. In: Dolphin D (ed) The Porphyrins, vol 7. Academic Press, London New York, pp 149–240

    Google Scholar 

  • Finzel BC, Poulos TL, Kraut J (1984) Crystal structure of yeast cytochrome c peroxidase refined at 1.7 Å resolution. J Biol Chem 259:13027–13036

    PubMed  CAS  Google Scholar 

  • Frey TG, Chan SH, Schatz G (1978) Structure and orientation of cytochrome c oxidase in crystalline membranes. Studies by electron microscopy and by labelling with subunit specific antibodies. J Biol Chem 253:4389–4395

    PubMed  CAS  Google Scholar 

  • Froud RJ, Ragan CI (1984) Cytochrome c mediates electron transfer between ubiquinol cytochrome c reductase and cytochrome c oxidase by free diffusion along the surface of the membrane. Biochem J 217:561–571

    PubMed  CAS  Google Scholar 

  • Fuller SD, Capaldi RA, Henderson R (1979) Structure of cytochrome c oxidase in deoxycholate derived two-dimensional crystals. J Mol Biol 134:305–327

    Article  PubMed  CAS  Google Scholar 

  • Fuller SD, Darley-Usmar VM, Capaldi RA (1981) Covalent complex between yeast cytochrome c and beef heart oxidase which is active in electron transfer. Biochemistry 20:7046–7053

    Article  PubMed  CAS  Google Scholar 

  • Fuller SD, Capaldi RA, Henderson R (1982) Preparation of two-dimensional arrays of purified beef heart cytochrome c oxidase. Biochemistry 21:2525–2529

    Article  PubMed  CAS  Google Scholar 

  • Gelder BF van, Buuren KJH van, Wilms J, Verboom CN (1975) The effect of ionic strength on the oxidation of cytochrome c by cytochrome oxidase. In: Quaglierello E, Papa S, Palmieri F, Slater EC, Siliprandi N (eds) Electron transport chains and oxidative phosphorylation. Elsevier/North Holland Biomedical Press, New York Amsterdam, pp 63–68

    Google Scholar 

  • Gelder BF van, Veerman E, Wilms J, Dekker HL (1979) The electron accepting site of cytochrome oxidase. In: King TE et al. (eds) Cytochrome oxidase. Elsevier/North Holland Biomedical Press, New York Amsterdam, pp 305—314

    Google Scholar 

  • Gelder BF van, Veerman E, Wilms J, Dekker HL (1982) The reaction between cytochrome c and cytochrome oxidase. In: King TE, Mason HS, Morrison M (eds) Proc Int Symp Oxidases and related redox systems. Pergamon, New York, pp 1055–1062

    Google Scholar 

  • Gellerfors P, Nelson BD (1977) Topology of the peptides in free and membrane bound com- plex III (UQ cytochrome c reductase) as revealed by lactoperoxidase and p-diazonium benzene (35S) sulfonate labelling. Eur J Biochem 80:275–282

    Article  PubMed  CAS  Google Scholar 

  • Georgevich G, Darley-Usmar VM, Malatesta F, Capaldi RA (1983) Electron transfer in monomeric forms of beef and shark cytochrome oxidase. Biochemistry 22:1317–1322

    Article  PubMed  CAS  Google Scholar 

  • Gervais M, Risler Y, Corazzin S (1983) Proteolytic cleavage of Hansenula anomala flavocytochrome b2 into its two functional domains. Eur J Biochem 130:253–259

    Article  PubMed  CAS  Google Scholar 

  • Gibson QH, Greenwood C (1965) Kinetic observations on the near-infra-red band of cytochrome c oxidase. J Biol Chem 240:2694–2698

    PubMed  CAS  Google Scholar 

  • Gibson QH, Greenwood C, Wharton DC, Palmer G (1965) The reaction of cytochrome oxidase with cytochrome c. J Biol Chem 240:888–894

    PubMed  CAS  Google Scholar 

  • Greenwood C, Brittain T, Wilson M, Brunori M (1976) Studies on partially reduced mammalian cytochrome oxidase reactions with ferrocytochrome c. Biochem J 157:591–598

    PubMed  CAS  Google Scholar 

  • Guiard B, Lederer F (1979a) The sequence of b5-like binding domain of chicken sulphite oxidase. Eur J Biochem 100:441–453

    Article  PubMed  CAS  Google Scholar 

  • Guiard B, Lederer F (1979b) The cytochrome b5 fold — structure of a novel protein super-family. J Mol Biol 135:639–650

    Article  PubMed  CAS  Google Scholar 

  • Guiard B, Groudinsky O, Lederer F (1974) Homology between bakers yeast cytochrome b5 and liver microsomal cytochrome b5. Proc Natl Acad Sci USA 71:2539–2543

    Article  PubMed  CAS  Google Scholar 

  • Gupta RK, Yonetani T (1973) Nuclear magnetic resonance studies of the interaction of cytochrome c with cytochrome c peroxidase. Biochim Biophys Acta 292:502–508

    Article  PubMed  CAS  Google Scholar 

  • Gupta RK, Konig SH, Redfield AG (1972) On the electron transfer between cytochrome c molecules as observed by NMR. J Mag Res 7:66–73

    CAS  Google Scholar 

  • Gutweniger H, Bisson T, Montecucco C (1981) Hydrophobic labelling of the yeast cytochrome c oxidase subunits in contact with lipids. Biochim Biophys Acta 635:187–193

    Article  PubMed  CAS  Google Scholar 

  • Gutweniger HE, Grassi C, Bisson R (1983) Interaction between cytochrome c and ubiquinone cytochrome c reductase — a study with water-soluble carbodiimides. Biochem Biophys Res Commun 116:272–283

    Article  PubMed  CAS  Google Scholar 

  • Hackenbrock CR (1981) Lateral diffusion and electron transfer in the mitochondrial inner membrane. Trends Biochem Sci 6:151–154

    Article  CAS  Google Scholar 

  • Hackett CS, Strittmatter P (1984) Covalent cross-linking of the active site of vesicle-bound cytochrome b5 and NADH cytochrome b5 reductase. J Biol Chem 259:3275–3282

    PubMed  CAS  Google Scholar 

  • Hakvoort TBM, Sinjorgo KMC, Gelder BF van, Muijsers AO (1985) Separation of enzymatically active bovine cytochrome c oxidase monomers and dimers by high performance liquid chromatography. J Inorg Biochem 23:381–388

    Article  PubMed  CAS  Google Scholar 

  • Hartzell CR, Hansen RE, Beinert H (1973) Electron carriers of cytochrome oxidase detectable by EPR and their relationship to those traditionally recognised in this enzyme. Proc Natl Acad Sci USA 70:2477–2481

    Article  PubMed  CAS  Google Scholar 

  • Hatefi Y, Rieske JS (1967) The preparation and properties of DPNH-cytochrome c reductase. Meth Enzymol 10:255–231

    Google Scholar 

  • Hatefi Y, Haavik AG, Griffiths DE (1962) Studies on the electron transfer system — reduced CoQ cytochrome c reductase. J Biol Chem 237:1681–1685

    PubMed  CAS  Google Scholar 

  • Hauska G, Hurt E, Gabellini N, Lockau W (1983) Comparative aspects of quinolcytochrome c/plastocyanin oxidoreductases. Biochim Biophys Acta 726:97–133

    PubMed  CAS  Google Scholar 

  • Henderson R, Unwin PNT (1975) Three-dimensional model of purple membrane obtained by electron microscopy. Nature (London) 257:28–32

    Article  CAS  Google Scholar 

  • Henderson R, Capaldi RA, Leigh JS (1977) Arrangement of cytochrome oxidase molecules in two dimensional vesicle crystals. J Mol Biol 112:631–648

    Article  PubMed  CAS  Google Scholar 

  • Hill BC, Greenwood C (1984) Kinetic evidence for the re-definition of electron transfer pathways from cytochrome c to 02 within cytochrome oxidase. FEBS Lett 166:362–366

    Article  PubMed  CAS  Google Scholar 

  • Hochman JH, Schindler M, Lee JG, Ferguson-Miller S (1982) Lateral mobility of cytochrome c on intact mitochondrial membranes as determined by fluorescence redistribution after photobleaching. Proc Natl Acad Sci USA 79:6866–6870

    Article  PubMed  CAS  Google Scholar 

  • Hochman JH, Ferguson-Miller S, Schindler M (1985) Mobility in the mitochondrial electron transport chain. Biochemistry 24:2509–2516

    Article  PubMed  CAS  Google Scholar 

  • Hoffman BM, Roberts JE, Kang CH, Margoliash E (1981) Electron paramagnetic and electron nuclear double resonance of the hydrogen peroxide compound of cytochrome c peroxidase. J Biol Chem 256:6556–6564

    PubMed  CAS  Google Scholar 

  • Hovmoller S, Leonard K, Weiss H (1981) Membrane crystals of a subunit complex of cytochrome reductase containing cytochrome b and c1. FEBS Lett 123:118–122

    Article  PubMed  CAS  Google Scholar 

  • Hummel JP, Dreyer WJ (1962) Measurement of protein binding phenomena by gel filtration. Biochim Biophys Acta 63:530–532

    Article  PubMed  CAS  Google Scholar 

  • Huttquist DE, Passon PG (1971) Catalysis of methemoglobin reduction by erythrocyte cytochrome b5 and cytochrome b5 reductase. Nature (London) 229:252–254

    Article  Google Scholar 

  • Ito A (1980) Cytochrome b5 — like hemoprotein of outer mitochondrial membranes. J Biochem 87:63–71

    PubMed  CAS  Google Scholar 

  • Jacobs EE, Sanadi DR (1960) The reversible removal of cytochrome c from mitochondria. J Biol Chem 235:531–534

    PubMed  CAS  Google Scholar 

  • Jacobs EE, Andrews EC, Crane FL (1964) A reaction scheme for cytochrome oxidase suggested by its characteristic reactions with high potential electron donors. In: King TE, Mason HS, Morrison M (eds) Oxidases and related redox systems. Wiley, London New York, pp 784–802

    Google Scholar 

  • Jacq C, Lederer F (1972) Sur les deux formes moléculaires du cytochrome b2 de Saccharomyces cerevisiae. Eur J Biochem 25:41–48

    Article  PubMed  CAS  Google Scholar 

  • Jacq C, Lederer F (1974) Cytochrome b2 from bakers yeast — a double headed enzyme. Eur J Biochem 41:311–320

    Article  PubMed  CAS  Google Scholar 

  • Jarausch J, Kadenbach B (1985a) Structure of the cytochrome c oxidase complex from rat liver — topographical orientation of polypeptides in the membrane as studied by proteolytic digestion and immunoblotting. Eur J Biochem 146:219–225

    Article  PubMed  CAS  Google Scholar 

  • Jarausch J, Kadenbach B (1985b) Structure of the cytochrome c oxidase complex of rat liver — studies on nearest neighbour relationships of polypeptides with cross-linking agents. Eur J Biochem 146:211–217

    Article  PubMed  CAS  Google Scholar 

  • Johnson JL, Rajagopalan KV (1977) Tryptic cleavage of rat liver sulfite oxidase. Isolation and characterisation of molybdenum and heme domains. J Biol Chem 252:2017–2025

    PubMed  CAS  Google Scholar 

  • Johnson JL, Rajagopalan KV (1980) The oxidation of sulfite in animal systems. In: Elliott K, Whelan J (eds) Sulfur in biology (CIBA foundation symposium). Exerpta Medica, Amsterdam, pp 119–133

    Google Scholar 

  • Kadenbach B, Stroh A (1984) Different reactivity of carboxylic groups of cytochrome oxidase polypeptides from pig liver and heart. FEBS Lett 173:374–380

    Article  PubMed  CAS  Google Scholar 

  • Kadenbach B, Ungibauer M, Jarausch J, Buge U, Kuhn-Nentwig L (1983) The complexity of respiratory complexes. Trends Biochem Sci 8:398–400

    Article  CAS  Google Scholar 

  • Kang CH, Ferguson-Miller S, Margoliash E (1977) Steady state kinetics and binding of eukaryotic cytochromes c with yeast cytochrome c peroxidase. J Biol Chem 252:919–926

    PubMed  CAS  Google Scholar 

  • Kang CH, Brautigan DL, Osheroff N, Margoliash E (1978) Definition of cytochrome c binding domains by chemical modifications. J Biol Chem 253:6502–6510

    PubMed  CAS  Google Scholar 

  • Kang DS, Erman JE (1982) The cytochrome c peroxidase catalysed oxidation of ferrocytochrome c by hydrogen peroxide. J Biol Chem 257:12775–12779

    PubMed  CAS  Google Scholar 

  • Kawato S, Sigel E, Carafoli E, Cherry RJ (1981) Rotation of cytochrome oxidase in phospholipid vesicles. J Biol Chem 256:7518–7527

    PubMed  CAS  Google Scholar 

  • Kayushin LP, Ajipa YI (1973) Cytochrome c nucleotide complexes and the role of unpaired electrons in coupling processes. Ann NY Acad Sci 222:255–265

    Article  PubMed  CAS  Google Scholar 

  • Keller RM, Groudinsky O, Wuthrich K (1973) Proton magnetic resonance of cytochrome b2 core-structural similarities with cytochrome b5. Biochim Biophys Acta 328:233–238

    PubMed  CAS  Google Scholar 

  • Kessler DL, Rajagopalan KV (1974) Hepatic sulfite oxidase — effects of anions on interaction with cytochrome c. Biochim Biophys Acta 370:389–398

    PubMed  CAS  Google Scholar 

  • Kim CH, King TE (1981) The indispensibility of a mitochondrial 15 K protein for the formation of the cytochrome c1: cytochrome c complex. Biochem Biophys Res Commun 101:607–614

    Article  PubMed  CAS  Google Scholar 

  • Kim CH, King TE (1983) A mitochondrial protein is essential for the formation of the cytochrome c1: cytochrome c complex. J Biol Chem 258:13543–13551

    PubMed  CAS  Google Scholar 

  • Kimura S, Abe K, Sugita Y (1984) Differences in C-terminal amino acid sequence between erythrocyte and liver cytochrome b5 isolated from pig and human. FEBS Lett 169:143–146

    Article  PubMed  CAS  Google Scholar 

  • King TE (1978) Cytochrome c, from mammalian heart. Meth Enzymol 53:181–191

    Article  PubMed  CAS  Google Scholar 

  • King TE (1982) Cardiac cytochrome c1. Adv Enzymol 54:267–360

    Google Scholar 

  • Konig BW, Schilder LTM, Tervoort MJ, Gelder BF van (1980) The isolation and purification of cytochrome c1 from bovine heart. Biochim Biophys Acta 621:283–295

    PubMed  CAS  Google Scholar 

  • Konig BW, Wilms J, Gelder BF van (1981) The reaction between cytochrome c1 and cytochrome c. Biochim Biophys Acta 636:9–16

    Article  PubMed  CAS  Google Scholar 

  • Koppenol WH, Margoliash E (1982) The asymmetric distribution of charges on the surface of cytochrome c. J Biol Chem 257:4426–4437

    PubMed  CAS  Google Scholar 

  • Koppenol WH, Vroonland CAJ, Braams R (1978) The electric potential field around cytochrome c and the effect of ionic strength on reaction rates. Biochim Biophys Acta 503:499–508

    Article  PubMed  CAS  Google Scholar 

  • Kuhn-Nentwig L, Kadenbach B (1985a) Isolation and properties of cytochrome c oxidase from rat liver and quantification of immunological differences between isozymes from various rat tissues with subunit specific antisera. Eur J Biochem 149:147–158

    Article  PubMed  CAS  Google Scholar 

  • Kuhn-Nentwig L, Kadenbach B (1985b) Orientation of rat liver cytochrome c oxidase subunits investigated with subunit specific antisera. Eur J Biochem 153:101–104

    Article  PubMed  CAS  Google Scholar 

  • Kuo LM, Davies HC, Smith L (1984) Effects of monoclonal antibodies to bovine and Paracoccus denitrificans cytochromes c on reactions with oxidase, reductase and peroxidase. Biochim Biophys Acta 766:472–482

    Article  PubMed  CAS  Google Scholar 

  • Labeyrie F, Groudinsky O, Jacqot-Armand Y, Naslin L (1966) Propriétés d’un hoyau cytochromique b2 résultant d’une Protéolyse de la L-lactate: cytochrome c oxydoreductase de la levure. Biochim Biophys Acta 128:492–503

    Google Scholar 

  • Labeyrie F, Franco A di, Iwatsubo M, Baudras A (1967) Fluorimetric and spectrophotometric study of heme binding of the apoprotein from a cytochrome b2 derivative. Biochemistry 6:1791–1797

    Article  PubMed  CAS  Google Scholar 

  • Lederer F, Ghrir R, Guiard B, Cortail S, Ito A (1983) Two homologous cytochromes b5 in a single cell. Eur J Biochem 132:95–102

    Article  PubMed  CAS  Google Scholar 

  • Leeuwen JM van (1983) The ionic strength dependence of a reaction between two large proteins with a dipole moment. Biochim Biophys Acta 743:408–421

    Article  PubMed  Google Scholar 

  • Leonard JJ, Yonetani T (1974) Interaction of cytochrome c peroxidase with cytochrome c. Biochemistry 13:1465–1468

    Article  PubMed  CAS  Google Scholar 

  • Leonard K, Wingfield P, Arad T, Weiss H (1981) Three-dimensional structure of ubiquinone cytochrome c reductase from Neurospora mitochondria determined by electron microscopy of membrane crystals. J Mol Biol 149:259–274

    Article  PubMed  CAS  Google Scholar 

  • Li Y, DeVries S, Leonard K, Weiss H (1981) Topography of the iron sulphur subunit in mitochondrial UQ cytochrome c reductase. FEBS Lett 135:277–280

    Article  PubMed  CAS  Google Scholar 

  • Loo S, Erman JE (1975) Kinetic study of reaction between cytochrome c peroxidase and H2O2-dependence on pH and ionic strength. Biochemistry 14:3467–3470

    Article  PubMed  CAS  Google Scholar 

  • Loon APGM van, DeGroot RJ, DeHaan M, Dekker A, Grivell LA (1984) The DNA sequence of the nuclear gene coding for the 17000 subunit VI of yeast ubiquinol cytochrome c reductase. EMBO 3:1039–1043

    Google Scholar 

  • Ludwig B (1980) Haem aa3 type cytochrome c oxidase from bacteria. Biochim Biophys Acta 594:177–189

    PubMed  CAS  Google Scholar 

  • Ludwig B, Schatz G (1980) A two subunit cytochrome c oxidase (aa3) from Paracoccus denitrificans. Proc Natl Acad Sci USA 77:196–200

    Article  PubMed  CAS  Google Scholar 

  • Ludwig B, Downer NW, Capaldi RA (1979) Labelling of cytochrome c oxidase with (35S) diazobenzene sulfonate. Orientation of the electron transfer complex in the inner mitochondrial membrane. Biochemistry 18:1401–1407

    Article  PubMed  CAS  Google Scholar 

  • Macleod RM, Farkas W, Fridovich I, Handler P (1961) Purification and properties of hepatic sulfite oxidase. J Biol Chem 236:1841–1846

    PubMed  CAS  Google Scholar 

  • Madden TD, Cullis PR (1985) Preparation of reconstituted cytochrome oxidase vesicles with defined transmembrane protein orientations employing a cytochrome c affinity column. Biochim Biophys Acta 808:219–224

    Article  PubMed  CAS  Google Scholar 

  • Malatesta F, Capaldi RA (1982) Localisation of Cys-115 in subunit III of beef heart cytochrome oxidase to the C-side of the mitochondrial inner membrane. Biochem Biophys Res Commun 109:1180–1185

    Article  PubMed  CAS  Google Scholar 

  • Malmström BG (1979) Cytochrome oxidase, structure and catalytic activity. Biochim Biophys Acta 549:281–303

    PubMed  Google Scholar 

  • Margalit R, Schejter A (1973a) The effects of temperature, pH and electrostatic media on the standard redox potential of cytochrome c. Eur J Biochem 32:492–499

    Article  PubMed  CAS  Google Scholar 

  • Margalit R, Schejter A (1973b) Ion-binding linked to oxidation state of cytochrome c. Eur J Biochem 32:500–505

    Article  PubMed  CAS  Google Scholar 

  • Margalit R, Schejter A (1974) Cation-binding to horse heart ferrocytochrome c. Eur J Biochem 46:387–391

    Article  PubMed  CAS  Google Scholar 

  • Margoliash E, Barlow GH, Byers V (1970) Differential binding properties of cytochrome c: possible relevance for mitochondrial ion transport. Nature (London) 228:723–726

    Article  CAS  Google Scholar 

  • Margoliash E, Ferguson-Miller S, Tulloss J, Kang CH, Feinberg BA, Brautigan DL, Morrison M (1973) Separate intramolecular pathways for reduction and oxidation of cytochrome c in electron transport chain reactions. Proc Natl Acad Sci USA 70:3245–3249

    Article  PubMed  CAS  Google Scholar 

  • Mathews FS (1984) The structure, function and evolution of cytochromes. Progr Biophys Mol Biol 45:1–56

    Article  Google Scholar 

  • Matlib MA, O’Brien PJ (1976) Properties of rat liver mitochondria with intermembrane cytochrome c. Arch Biochem Biophys 173:27–33

    Article  PubMed  CAS  Google Scholar 

  • Matthew JB, Weber PC, Salemme FR, Richards FM (1983) Electrostatic orientation during electron transfer between flavodoxin and cytochrome c. Nature (London) 301:169–171

    Article  CAS  Google Scholar 

  • Mauk MR, Reid LS, Mauk AG (1982) Spectrophotometric analysis of the interaction between cytochrome b5 and cytochrome c. Biochemistry 21:1843–1846

    Article  PubMed  CAS  Google Scholar 

  • Mauk MR, Mauk G, Weber PC, Matthew JB (1986) Role of the cytochrome b5 heme propionates in the interaction between cytochrome b5 and cytochrome c. Biochemistry 25:7085–7091

    Article  PubMed  CAS  Google Scholar 

  • McLendon GL, Winkler JR, Nocera DG, Mauk MR, Mauk AG, Gray HB (1985) Quenching of zinc-substituted cytochrome c excited states by cytochrome b5. J Am Chem Soc 107:739–740

    Article  CAS  Google Scholar 

  • Merle P, Kadenbach B (1982) Kinetic and structural differences between cytochrome c oxidase from beef liver and heart. Eur J Biochem 125:239–244

    Article  PubMed  CAS  Google Scholar 

  • Michel B, Bosshard HR (1984) Spectroscopic analysis of the interaction between cytochrome c and cytochrome aa3. J Biol Chem 259:10085–10091

    PubMed  CAS  Google Scholar 

  • Miller WG, Cusanovich MA (1973) The reaction of horse cytochrome c with anionic reductants. Biophys Str Mech 1:97–111

    Article  Google Scholar 

  • Millet F, Darley-Usmar V, Capaldi RA (1982) Cytochrome c is cross-linked to subunit II of cytochrome c oxidase by a water soluble carbodiimide. Biochemistry 21:3857–3862

    Article  Google Scholar 

  • Millet F, DeJong C, Paulson L, Capaldi RA (1983) Identification of specific carboxylate groups on cytochrome c oxidase that are involved in binding to cytochrome c. Biochemistry 22:546–552

    Article  Google Scholar 

  • Minnaert K (1961) The kinetics of cytochrome oxidase. Biochim Biophys Acta 50:23–34

    Article  PubMed  CAS  Google Scholar 

  • Mitchell P (1980) Proton motive cytochrome system of mitochondria. Ann N Y Acad Sci 341:564–581

    Article  PubMed  CAS  Google Scholar 

  • Mochan E (1970) The nature of complex formation between cytochrome c and cytochrome c peroxidase. Biochim Biophys Acta 216:80–95

    Article  PubMed  CAS  Google Scholar 

  • Mochan E, Nicholls P (1971) Complex formation between cytochrome c and cytochrome c peroxidase. Biochem J 121:69–82

    PubMed  CAS  Google Scholar 

  • Mochan E, Nicholls P (1972) Cytochrome c reactivity in its complexes with mammalian cytochrome c oxidase and yeast peroxidase. Biochim Biophys Acta 267:309–319

    Article  PubMed  CAS  Google Scholar 

  • Moreland RB, Dockter ME (1981) Interaction of the back of yeast iso-1-cytochrome c with yeast cytochrome oxidase. Biochem Biophys Res Commun 99:339–346

    Article  PubMed  CAS  Google Scholar 

  • Morton RA, Breskvar K (1977) Ion binding to lysine modified derivatives of cytochrome c. Can J Biochem 55:146–151

    Article  PubMed  CAS  Google Scholar 

  • Morton RK, Sturtevant JM (1964) Kinetic investigations of yeast L-lactate dehydrogenase (cytochrome b2). J Biol Chem 239:1614–1624

    PubMed  CAS  Google Scholar 

  • Myer P, Thallum KK, Pande J, Verma BC (1980) Selectivity of oxidase and reductase activity of horse heart cytochrome c. Biochem Biophys Res Commun 94:1106–1112

    Article  PubMed  CAS  Google Scholar 

  • Nalecz KA, Bolli R, Azzi A (1983) Preparation of monomeric cytochrome c oxidase: its kinetics differ from those of the dimeric enzyme. Biochem Biophys Res Commun 114:822–828

    Article  PubMed  CAS  Google Scholar 

  • Ng S, Smith MB, Smith HT, Millet F (1977) Effect of modification of individual cytochrome c lysines on reaction with cytochrome b5. Biochemistry 16:4975–4978

    Article  PubMed  CAS  Google Scholar 

  • Nicholls P (1964a) Observations on the oxidation of cytochrome c. Arch Biochem Biophys 106:25–48

    Article  PubMed  CAS  Google Scholar 

  • Nicholls P (1964b) Cytochrome oxidase in situ: concepts and questions. In: King TE, Mason HS, Morrison M (eds) Oxidases and related redox systems, vol 2. Wiley & Sons, New York, pp 764–783

    Google Scholar 

  • Nicholls P (1974) Cytochrome c binding to enzymes and membranes. Biochim Biophys Acta 346:271–310

    Google Scholar 

  • Nicholls P (1976) Catalytic activity of cytochromes c and c1 in mitochondria and submitochondrial particles. Biochim Biophys Acta 430:30–45

    Article  PubMed  CAS  Google Scholar 

  • Nicholls P, Chance B (1974) Cytochrome c oxidase. In: Hayaishi O (ed) Molecular Mechanisms of oxygen activation. Academic Press, London New York, pp 479–534

    Google Scholar 

  • Nicholls P, Mochan E (1971) Complex formation between cytochrome c and cytochrome c peroxidase — kinetic studies. Biochem J 121:55–67

    PubMed  CAS  Google Scholar 

  • Nicholls P, Mochan E, Kimelberg HK (1969) Complex formation by cytochrome c: a clue to the structure and polarity of the inner mitochondrial membrane. FEBS Lett 3:242–246

    Article  PubMed  CAS  Google Scholar 

  • Ohnishi T, Kawaguchi K, Hagihara B (1966) Preparation and some properties of yeast mitochondria. J Biol Chem 241:1797–1806

    PubMed  CAS  Google Scholar 

  • Osheroff N, Borden D, Koppenol WH, Margoliash E (1979) The evolutionary control of cytochrome c function. In: King TE, Orii Y, Chance B, Okunuki K (eds) Cytochrome oxidase. Elsevier, Amsterdam, pp 385–394

    Google Scholar 

  • Osheroff N, Brautigan DL, Margoliash E (1980) Definition of enzymie domains on cytochrome c. J Biol Chem 255:8245–8251

    PubMed  CAS  Google Scholar 

  • Osheroff N, Speck SH, Margoliash E, Veerman EC, Wilms J, Konig BW, Muisjers AO (1983) The reaction of primate cytochrome c with cytochrome oxidase. J Biol Chem 258:5731–5738

    PubMed  CAS  Google Scholar 

  • Oshino N, Chance B (1975) Interaction of sulfite oxidase with the mitochondrial respiratory chain. Arch Biochem Biophys 170:514–528

    Article  PubMed  CAS  Google Scholar 

  • Peterman BF, Morton RA (1977) The oxidation of ferrocytochrome c in non-binding buffer. Can J Biochem 55:796–803

    Article  PubMed  CAS  Google Scholar 

  • Petersen LC (1978) Cytochrome c: cytochrome aa3 complex formation at low ionic strength studied by aqueous two phase partition. FEBS Lett 94:105–108

    Article  PubMed  CAS  Google Scholar 

  • Petersen LC, Cox RP (1980) The effect of complex formation with polyanions on the redox properties of cytochrome c. Biochem J 192:687–693

    PubMed  CAS  Google Scholar 

  • Pettigrew GW (1978) Mapping an electron transfer site on cytochrome c. FEBS Lett 86:14–18

    Article  PubMed  CAS  Google Scholar 

  • Pettigrew GW, Seilman S (1982) Properties of a cross-linked complex between cytochrome c and cytochrome c peroxidase. Biochem J 201:9–18

    PubMed  CAS  Google Scholar 

  • Poulos TL, Finzel BC (1984) Heme enzyme structure and function. In: Hearn M W (ed) Peptide and protein reviews, vol 4. Dekker, New York, pp 115–141

    Google Scholar 

  • Poulos TL, Kraut J (1980) A hypothetical model of the cytochrome c peroxidase: cytochrome c electron transfer complex. J Biol Chem 255:10322–10330

    PubMed  CAS  Google Scholar 

  • Poulos TL, Freer ST, Alden RA, Edwards SL, Skoglund U, Takio K, Eriksson B, Xuong NH, Yonetani T, Kraut J (1980) Crystal structure of cytochrome c peroxidase. J Biol Chem 255:575–580

    PubMed  CAS  Google Scholar 

  • Power SD, Lochrie MA, Sevarino KA, Patterson TE, Poyton RO (1984a) The nuclear coded subunits of yeast cytochrome c oxidase. J Biol Chem 259:6564–6570

    PubMed  CAS  Google Scholar 

  • Power SD, Lochrie MA, Patterson TE, Poyton RO (1984b) The nuclear coded subunits of yeast cytochrome c oxidase. J Biol Chem 259:6571–6574

    PubMed  CAS  Google Scholar 

  • Power SD, Lochrie MA, Poyton RO (1984c) The nuclear coded subunits of yeast cytochrome c oxidase — identification of homologous subunits in yeast, bovine heart and Neurospora crassa cytochrome c oxidase. J Biol Chem 259:6575–6578

    PubMed  CAS  Google Scholar 

  • Prats M (1977) Complexes entre les L(+) lactate cytochrome c oxydoréductase extrait des levures Saccharomyces cereviseae on Hansenula anomala et le cytochrome c de coeur de cheval. Biochimie 59:621–626

    Article  PubMed  CAS  Google Scholar 

  • Prochaska L, Bisson R, Capaldi RA (1980) Structure of the cytochrome c oxidase complex: labelling by hydrophilic and hydrophobic protein modifying reagents. Biochemistry 19:3174–3180

    Article  PubMed  CAS  Google Scholar 

  • Reynafarge B, Alexandre A, Davies P, Lehninger AL (1982) Proton translocation stoichiometry of cytochrome oxidase. Proc Natl Acad Sci USA 79:7218–7222

    Article  Google Scholar 

  • Rich PR (1984) Electron and proton transfers through quinones and cytochrome bct complexes. Biochim Biophys Acta 768:53–79

    PubMed  CAS  Google Scholar 

  • Rieder R, Bosshard HR (1978) The cytochrome c oxidase binding site on cytochrome c. Differential chemical modification of lysine residues in free and oxidase-bound cytochrome c. J Biol Chem 253:6045–6053

    PubMed  CAS  Google Scholar 

  • Rieder R, Bosshard HR (1980) Comparison of the binding sites for cytochrome c oxidase, cytochrome bc1 and cytochrome c1. J Biol Chem 255:4732–4739

    PubMed  CAS  Google Scholar 

  • Rieske JS (1967) Preparation and properties of reduced Coenzyme Q-cytochrome c reductase. Meth Enzymol 10:239–245

    Article  CAS  Google Scholar 

  • Rieske JS, Zaugg WS, Hansen RE (1964) Distribution of iron and of the compound giving an electron paramagnetic resonance signal at g = 1.9 in a subfraction of complex III. J Biol Chem 239:3023–3030

    PubMed  CAS  Google Scholar 

  • Risler JL, Groudinsky O (1973) Magnetic circular dichroism studies of cytochrome c and cytochrome b2. Eur J Biochem 35:201–205

    Article  PubMed  CAS  Google Scholar 

  • Roberts H, Hess B (1977) Kinetics of cytochrome c oxidase from yeast. Biochim Biophys Acta 462:215–234

    Article  PubMed  CAS  Google Scholar 

  • Robinson NC, Capaldi RA (1977) Interaction of detergents with cytochrome c oxidase. Biochemistry 16:375–381

    Article  PubMed  CAS  Google Scholar 

  • Robinson NC, Talbert L (1980) Isolation of bovine cytochrome c1 as a single non-denatured subunit using gel filtration or high pressure liquid chromatography in deoxycholate. Biochem Biophys Res Commun 95:90–96

    Article  PubMed  CAS  Google Scholar 

  • Rosevear P, Akeem T van, Baxter J, Ferguson-Miller S (1980) Alkyl glycoside detergents — a simpler synthesis and their effects on kinetic and physical properties of cytochrome c oxidase. Biochemistry 19:4108–4115

    Article  PubMed  CAS  Google Scholar 

  • Ross EM, Schatz G (1976) Purification of cytochrome c1 from yeast. J Biol Chem 251:1991–1996

    PubMed  CAS  Google Scholar 

  • Ross EM, Schatz G (1978) Purification and subunit composition of cytochrome c1 from bakers yeast. Meth Enzymol LIII:222–229

    Article  Google Scholar 

  • Ross PD, Subramanian S (1981) Thermodynamics of protein association reactions. Biochemistry 20:3096–3102

    Article  PubMed  CAS  Google Scholar 

  • Salemme FR (1976) An hypothetical structure for an intermolecular electron transfer complex of cytochrome c and cytochrome b5. J Mol Biol 102:563–568

    Article  PubMed  CAS  Google Scholar 

  • Saraste M (1983) How complex is a respiratory complex. Trends Biochem Sci 8:139–142

    Article  CAS  Google Scholar 

  • Saraste M, Pentilla T, Wikstrom M (1981) Quaternary structure of bovine cytochrome oxidase. Eur J Biochem 115:261–268

    Article  PubMed  CAS  Google Scholar 

  • Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann N Y Acad Sci 51:660–672

    Article  CAS  Google Scholar 

  • Sebald W, Neupert W, Weiss H (1979) Preparation of Neurospora crassa mitochondria. Meth Enzymol LV:144–148

    Article  Google Scholar 

  • Senior AE (1983) Secondary and tertiary structure of membrane proteins involved in proton translocation. Biochim Biophys Acta 726:81–95

    PubMed  CAS  Google Scholar 

  • Shimomura Y, Mishikimi M, Ozawa T (1985) Novel purification of cytochrome c1 from mitochondrial complex III. J Biol Chem 260:15075–15080

    PubMed  CAS  Google Scholar 

  • Sjostrand FS (1978) The structure of mitochondrial membranes. A new concept. J Ultrastruct Res 64:217–245

    Article  PubMed  CAS  Google Scholar 

  • Smith HT, Millet F (1980) 19F NMR study of the interaction between cytochrome c and cytochrome c peroxidase. Biochim Biophys Acta 626:64–72

    PubMed  CAS  Google Scholar 

  • Smith HT, Staudenmeyer N, Millet F (1977) Use of lysine specific modifications to locate the reaction site of cytochrome c with cytochrome oxidase. Biochemistry 16:4971–4978

    Article  PubMed  CAS  Google Scholar 

  • Smith HT, Ahmed AJ, Millet F (1981) Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase. J Biol Chem 256:4984–4990

    PubMed  CAS  Google Scholar 

  • Smith L (1978) Purification of bacterial cytochromes c by isoelectric focusing. Meth Enzymol 53:229–231

    Article  PubMed  CAS  Google Scholar 

  • Smith L, Conrad H (1956) The kinetics of oxidation of cytochrome c by cytochrome oxidase. Arch Biochem Biophys 63:403–413

    Article  PubMed  CAS  Google Scholar 

  • Smith L, Nava ME, Margoliash E (1973a) In: King TE, Mason HS, Morrison M (eds) Oxidases and related redox systems, vol. 2. Univ Park Press, Baltimore, pp 629–638

    Google Scholar 

  • Smith L, Davies HC, Reichlin M, Margoliash E (1973b) Separate oxidase and reductase reaction sites on cytochrome c demonstrated with purified site-specific antibodies. J Biol Chem 248:237–243

    PubMed  CAS  Google Scholar 

  • Smith L, Davies H, Nava M (1974) Oxidation and reduction of soluble cytochrome c by membrane-bound oxidase and reductase systems. J Biol Chem 249:2904–2910

    PubMed  CAS  Google Scholar 

  • Smith L, Davies HC, Nava ME (1976) Evidence for binding sites on cytochrome c for oxidase and reductases from studies of different cytochromes c of known structure. Biochemistry 15:5827–5831

    Article  CAS  Google Scholar 

  • Smith L, Davies HC, Nava ME (1979a) Kinetics of reaction of cytochrome c with cytochrome oxidase. In: King TE et al. (eds) Cytochrome oxidase. Elsevier, Amsterdam, pp 293–304

    Google Scholar 

  • Smith L, Davies HC, Nava NE (1979b) Studies on the kinetics of oxidation of cytochrome c by cytochrome oxidase. Comparison of the spectrophotometric and Polarographic methods. Biochemistry 18:3140–3146

    Article  PubMed  CAS  Google Scholar 

  • Smith L, Davies HC, Nava NE (1980) Effect of ATP and ADP on the oxidation of cytochrome c by cytochrome c oxidase. Biochemistry 19:1613–1617

    Article  PubMed  CAS  Google Scholar 

  • Smith MB, Stonehuerner J, Ahmed A J, Staudenmeyer N, Millet F (1980) Use of specific trifluoroacetylation of lysine residues in cytochrome c to study the reaction with cytochrome b5, cytochrome c1 and cytochrome oxidase. Biochim Biophys Acta 592:303–313

    Article  PubMed  CAS  Google Scholar 

  • Smith RJ, Capaldi RA (1977) Nearest neighbour relationships of the polypeptides in ubiquinone cytochrome c reductase. Biochemistry 16:2629–2633

    Article  PubMed  CAS  Google Scholar 

  • Somero GN, Low PS (1976) Temperature — a shaping force in protein evolution. Biochem Soc Symp 41:33–42

    PubMed  CAS  Google Scholar 

  • Speck SH, Margoliash E (1984) Characterisation of the interaction of cytochrome c and mitochondrial ubiquinol cytochrome c reductase. J Biol Chem 259:1064–1072

    PubMed  CAS  Google Scholar 

  • Speck SH, Ferguson-Miller S, Osheroff N, Margoliash E (1979) Definition of cytochrome c binding domains by chemical modification — kinetics of reaction with beef mitochondrial reductase and functional organisation of the respiratory chain. Proc Natl Acad Sci USA 76:155–159

    Article  PubMed  CAS  Google Scholar 

  • Speck SH, Koppenol WH, Dethmers JK, Osheroff N, Margoliash E (1981) Definition of cytochrome c binding domains by chemical modification. J Biol Chem 256:7394–7400

    PubMed  CAS  Google Scholar 

  • Speck SH, Neu CA, Swanson MS, Margoliash E (1983) Role of phospholipid in the low affinity reactions between cytochrome c and cytochrome c peroxidase. FEBS Lett 164:379–382

    Article  PubMed  CAS  Google Scholar 

  • Speck SH, Dye D, Margoliash E (1984) Single catalytic site model for the oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase. Proc Natl Acad Sci USA 81:347–351

    Article  PubMed  CAS  Google Scholar 

  • Staudenmeyer N, Ng S, Smith MB, Millet F (1977) Effect of specific trifluoroacetylation of individual cytochrome c lysines on the reaction with cytochrome oxidase. Biochemistry 16:600–604

    Article  Google Scholar 

  • Steffens GJ, Buse G (1979) Primary structure and function of subunit II of cytochrome c oxidase. Hoppe-Seylers’s Z Physiol Chem 360:613–619

    CAS  Google Scholar 

  • Stellwagen E (1978) Heme exposure as the determinant of oxidation reduction potentials of heme proteins. Nature (London) 275:73–74

    Article  CAS  Google Scholar 

  • Stellwagen E, Schulman RG (1973) NMR study of exchangeable protons in ferrocytochrome c. J Mol Biol 75:683–695

    Article  PubMed  CAS  Google Scholar 

  • Stonehuerner J, Williams JB, Millet F (1979) Interaction between cytochrome c and cytochrome b5. Biochemistry 18:5422–5427

    Article  PubMed  CAS  Google Scholar 

  • Stonehuerner J, O’Brien P, Geren L, Millet F, Steidl J, Yu L, Yu CA (1985) Identification of the binding site on cytochrome c1 for cytochrome c. J Biol Chem 260:5392–5398

    PubMed  CAS  Google Scholar 

  • Strittmatter P (1964) A simple micro stopped flow apparatus. In: Chance B, Eisenhardt RH, Gibson QH, Lunberg KK (eds) Rapid mixing and sampling techniques in biochemistry. Academic Press, London New York, pp 71–84

    Google Scholar 

  • Strittmatter P, Spatz L, Corcoran D, Rogers MJ, Setlow B, Redline R (1974) Purification and properties of rat liver microsomal stearyl coenzyme A desaturase. Proc Natl Acad Sci USA 71:4565–4569

    Article  PubMed  CAS  Google Scholar 

  • Swanson M, Speck S, Koppenol WH, Margoliash E (1982) Cytochrome c mobility in the eukaryotic electron transport chain. In: Chien Ho (ed) Electron transport and oxygen utilisation. Elsevier, Amsterdam, pp 51–56

    Google Scholar 

  • Taborsky G (1979) Interaction of ferrous cytochrome c, ferrous ions and phosphate. J Biol Chem 254:5246–5251

    PubMed  CAS  Google Scholar 

  • Taborsky G, McCollum K (1979) Phosphate binding by cytochrome c. J Biol Chem 254:7069–7075

    PubMed  CAS  Google Scholar 

  • Thomas MA, Gervais M, Favaudon V, Valat P (1983) Study of the Hansenula anomala yeast flavocytochrome b2-cytochrome c complex. Eur J Biochem 135:577–581

    Article  PubMed  CAS  Google Scholar 

  • Thompson DA, Ferguson-Miller S (1983) Lipid and subunit III-depleted cytochrome c oxidase purified by horse cytochrome c — affinity chromatography in lauryl maltoside. Biochemistry 22:3178–3187

    Article  PubMed  CAS  Google Scholar 

  • Thompson DA, Suarez-Villafane M, Ferguson-Miller S (1982) The active form of cytochrome c oxidase. Biophys J 37:285–292

    Article  PubMed  CAS  Google Scholar 

  • Tollin G, Cheddar G, Watkins JA, Meyer TE, Cusanovich MA (1984) Electron transfer between flavodoxin semiquinone and c-type cytochromes: correlations between electrostatically corrected rate constants, redox potentials and surface topologies. Biochemistry 23:6345–6349

    Article  PubMed  CAS  Google Scholar 

  • Trumpower BL, Katki A (1975) Controlled digestion with trypsin as a structural probe for the N-terminal peptide of soluble and membraneous cytochrome c1. Biochemistry 14:3635–3642

    Article  PubMed  CAS  Google Scholar 

  • Vanderkooi J, Erecinska M, Chance B (1973a) Use of fluorescent probes in the study of cytochrome c interaction with the mitochondrial membrane. Arch Biochem Biophys 154:219–229

    Article  PubMed  CAS  Google Scholar 

  • Vanderkooi J, Erecinska M, Chance B (1973b) Comparative study of the interaction of cytochrome c with the mitochondrial membrane. Arch Biochem Biophys 157:531–540

    Article  PubMed  CAS  Google Scholar 

  • Vanderkooi JM, Glatz P, Casadel J, Woodrow GV (1980) Cytochrome c interaction with yeast cytochrome b2. Eur J Biochem 110:189–196

    Article  PubMed  CAS  Google Scholar 

  • Vanderkooi JM, Maniara G, Erecinska M (1985) Mobility of fluorescent derivatives of cytochrome c in mitochondria. J Cell Biol 100:435–441

    Article  PubMed  CAS  Google Scholar 

  • Veerman ECI, Wilms J, Casteleijn G, Gelder BF van (1980) The pre-steady-state reaction of ferrocytochrome c with cytochrome c:aa3 complex. Biochim Biophys Acta 590:117–127

    Article  PubMed  CAS  Google Scholar 

  • Veerman ECI, Leeuwen JW van, Buuren KJH van, Gelder BF van (1982) Reaction of cytochrome aa3 with porphyrin cytochrome c as studied by pulse radiolysis. Biochim Biophys Acta 680:134–141

    Article  PubMed  CAS  Google Scholar 

  • Veerman ECI, Wilms J, Dekker HL, Muisjers AO, Buuren KJH van, Gelder BF van (1983) The pre-steady-state reaction of chemically modified cytochromes c with cytochrome oxidase. J Biol Chem 258:5739–5745

    PubMed  CAS  Google Scholar 

  • Vik SB, Georgevich G, Capaldi RA (1981) Diphosphatidyl glycerol is required for optimal activity of beef heart cytochrome c oxidase. Proc Natl Acad Sci USA 78:1456–1460

    Article  PubMed  CAS  Google Scholar 

  • Wada K, Okunuki K (1969) Studies on chemically modified cytochrome c — the trinitrophenylated cytochrome c. J Biochem 66:249–262

    PubMed  CAS  Google Scholar 

  • Wakabayashi S, Matsubara H, Kim CH, King TE (1982a) Structural studies of bovine heart cytochrome c1. J Biol Chem 257:9335–9344

    PubMed  CAS  Google Scholar 

  • Wakabayashi S, Takeda H, Matsubara H, Kim CH, King TE (1982b) Identity of a haem-not-containing protein of bovine heart cytochrome c1 preparation with the protein mediating c1-c complex formation. J Biochem 91:2077–2085

    PubMed  CAS  Google Scholar 

  • Waldmeyer B, Bosshard HR (1985) Structure of an electron transfer complex — covalent cross-linking of cytochrome c peroxidase and cytochrome c. J Biol Chem 260:5184–5190

    PubMed  CAS  Google Scholar 

  • Waldmeyer B, Bechtold R, Zurrer M, Bosshard HR (1980) Cross-linking of cytochrome c to peroxidase: covalent complex catalyses oxidation of cytochrome c by H2O2. FEBS Lett 119:349–351

    Article  PubMed  CAS  Google Scholar 

  • Waldmeyer B, Bechtold R, Bosshard HR, Poulos TL (1982) The cytochrome c peroxidase: cytochrome c electron transfer complex. Experimental support of a hypothetical model. J Biol Chem 257:6073–6076

    PubMed  CAS  Google Scholar 

  • Webb M, Stonehuerner J, Millet F (1980) The use of specific lysine modifications to locate the reaction site on cytochrome c with sulfite oxidase. Biochim Biophys Acta 593:290–298

    Article  PubMed  CAS  Google Scholar 

  • Weiss H (1976) Subunit composition and biogenesis of mitochondrial cytochrome b. Biochim Biophys Acta 456:291–313

    PubMed  Google Scholar 

  • Weiss H, Juchs B (1978) Isolation of a multiprotein complex containing cytochrome b and c1 from Neurospora crassa mitochondria by affinity chromatography. Eur J Biochem 88:17–28

    Article  PubMed  CAS  Google Scholar 

  • Weiss H, Kolb H J (1979) Isolation of mitochondrial succinate UQ reductase, cytochrome c reductase and cytochrome c oxidase from Neurospora crassa mitochondria by affinity chromatography. Eur J Biochem 99:139–149

    Article  PubMed  CAS  Google Scholar 

  • Weiss H, Wingfield P (1979) Enzymology of ubiquinone-utilising electron transfer complexes in non-ionic detergent. Eur J Biochem 99:151–160

    Article  PubMed  CAS  Google Scholar 

  • Wherland S, Gray HB (1976) Metalloprotein electron transfer reactions — analysis of reactivity of horse cytochrome c with inorganic complexes. Proc Natl Acad Sci USA 73:2950–2954

    Article  PubMed  CAS  Google Scholar 

  • Wikström M (1984) Pumping of protons from the mitochondrial matrix by cytochrome c oxidase. Nature (London) 208:558–560

    Article  Google Scholar 

  • Wikström M, Krab K (1979) Proton-pumping cytochrome c oxidase. Biochim Biophys Acta 549:177–222

    PubMed  Google Scholar 

  • Wikström M, Krab K, Saraste M (1981) Proton-translocating cytochrome complexes. Annu Rev Biochem 50:623–655

    Article  PubMed  Google Scholar 

  • Williams JN (1968) Molecular proportion of the fixed cytochrome components of the respiratory chain of Keilin Hartree particles and beef heart mitochondria. Biochim Biophys Acta 113:175–178

    Google Scholar 

  • Williams JN, Thorp SL (1970) Influence of degradative procedures, salts, respiratory inhibitors and gramicidin on the binding of a cytochrome c by liver mitochondria. Arch Biochem Biophys 141:622–631

    Article  PubMed  CAS  Google Scholar 

  • Williams RJP (1970) The Biochemistry of Sodium, Potassium, Magnesium and Calcium. Q Rev 24:331–365

    Article  CAS  Google Scholar 

  • Wilms J, Dekker HL, Boelens R, Gelder BF van (1981a) The effect of pH and ionic strength on the pre-steady-state reaction of cytochrome c and cytochrome aa3. Biochim Biophys Acta 637:168–176

    Article  PubMed  CAS  Google Scholar 

  • Wilms J, Veerman ECI, Konig BW, Dekker HL, Gelder BF van (1981b) Ionic strength effects on cytochrome aa3 kinetics. Biochim Biophys Acta 635:13–24

    Article  PubMed  CAS  Google Scholar 

  • Wilson MT, Greenwood C, Brunori M, Antonini E (1975) Kinetic studies on the reaction between cytochrome c oxidase and ferrocytochrome c. Biochem J 147:145–153

    PubMed  CAS  Google Scholar 

  • Wingfield P, Arad T, Leonard K, Weiss H (1979) Membrane crystals of Ubiquinone: cytochrome c reductase from Neurospora mitochondria. Nature (London) 280:696–697

    Article  CAS  Google Scholar 

  • Winter DB, Bruyninckx WJ, Foulke FG, Grinich NP, Mason HS (1980) Location of heme a on subunits I and II and copper on subunit II of cytochrome oxidase. J Biol Chem 255:11408–11414

    PubMed  CAS  Google Scholar 

  • Wojtzcak L, Sottocasa GL (1972) Impermeability of the outer mitochondrial membrane to cytochrome c. J Membr Biol 7:313–324

    Article  Google Scholar 

  • Xia Z, Shamala N, Bethge PH, Lim LW, Bellamy HD, Lederer F, Mathews FS (1986) 3-dimensional structure of flavocytochrome b2 from bakers yeast at 3 Å resolution. In press

    Google Scholar 

  • Yonetani T (1976) Cytochrome c peroxidase. In: Boyer PD (ed) The enzymes, vol 13. Academic Press, London New York, pp 345–361

    Chapter  Google Scholar 

  • Yonetani T, Ray GS (1965) Studies on cytochrome c peroxidase. Purification and some properties. J Biol Chem 240:4503–4514

    PubMed  CAS  Google Scholar 

  • Yonetani T, Ray GS (1966) Studies on cytochrome c peroxidase. J Biol Chem 241:700–706

    PubMed  CAS  Google Scholar 

  • Yonetani T, Schleyer H, Ehrenberg A (1966) Studies on cytochrome c peroxidase: epr absorption of the enzyme and complex ES in dissolved and crystalline forms. J Biol Chem 241:3240–3243

    PubMed  CAS  Google Scholar 

  • Yoshimura T, Matsubara A, Aki K (1977) Formation of a complex between yeast L-lactate dehydrogenase (cytochrome b2) and cytochrome c. Ultracentrifugal and gel chromatographic analysis. Biochim Biophys Acta 492:331–339

    PubMed  CAS  Google Scholar 

  • Yoshimura T, Sogabe T, Aki K (1981) Electron transfer between horse and Candida cytochromes c in the bound and free states. Biochim Biophys Acta 636:129–135

    Article  PubMed  CAS  Google Scholar 

  • Yu CA, Yu L, King TE (1972) Purification of cytochrome c1 from cardiac muscle. J Biol Chem 247:1012–1019

    PubMed  CAS  Google Scholar 

  • Yu CA, Yu L, King TE (1973) Kinetics of electron transfer between cardiac cytochrome c1 and cytochrome c. J Biol Chem 248:528–533

    PubMed  CAS  Google Scholar 

  • Yu L, Yu C, King TE (1977) Subunit structure of the reconstitutively active cytochrome bc1 complex. Biochim Biophys Acta 495:232–247

    PubMed  CAS  Google Scholar 

  • Yun L, Leonard K, Weiss H (1981) Membrane and water-soluble cytochrome c1 from Neurospora mitochondria. Eur J Biochem 116:199–205

    Article  Google Scholar 

  • Zhang YZ, Georgevich G, Capaldi PA (1984) Topology of beef heart cytochrome c oxidase from studies on reconstituted membranes. Biochemistry 23:5616–5621

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Royal (Dick) School of Veterinary Studies, Summerhall, EH9 1QH, Edinburgh, UK

    Dr. Graham W. Pettigrew

  2. School of Chemical Sciences, University of East Anglia, NR4 7TJ, Norwich, UK

    Dr. Geoffrey R. Moore

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  1. Dr. Graham W. Pettigrew
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© 1987 Springer-Verlag Berlin Heidelberg

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Pettigrew, G.W., Moore, G.R. (1987). The Role of Mitochondrial Cytochrome c in Electron Transport. In: Cytochromes c. Springer Series in Molecular Biology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72698-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-72698-9_2

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