Possible Sites for Deficient Glucose Recognition in Islet Cells

  • W. J. Malaisse


In certain non-insulin-dependent diabetic patients, the secretory capacity of the pancreatic B-cell appears to be more severely affected in response to stimulation by D-glucose than other secretagogues [1]. Since D-glucose represents a major, albeit not the sole, regulator of insulin release under physiological conditions [2], the mechanisms possibly responsible for impaired recognition of this hexose by islet cells are directly relevant to our understanding of the pathology of the endocrine pancreas in diabetes mellitus.


Islet Cell Pancreatic Islet Insulin Release Hexose Transport RINm5F Cell 
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© Springer-Verlag Berlin Heidelberg 1988

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  • W. J. Malaisse

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