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Possible Sites for Deficient Glucose Recognition in Islet Cells

  • W. J. Malaisse

Abstract

In certain non-insulin-dependent diabetic patients, the secretory capacity of the pancreatic B-cell appears to be more severely affected in response to stimulation by D-glucose than other secretagogues [1]. Since D-glucose represents a major, albeit not the sole, regulator of insulin release under physiological conditions [2], the mechanisms possibly responsible for impaired recognition of this hexose by islet cells are directly relevant to our understanding of the pathology of the endocrine pancreas in diabetes mellitus.

Keywords

Islet Cell Pancreatic Islet Insulin Release Hexose Transport RINm5F Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Robertson RP, Porte Jr D (1973) The glucose receptor. A defective mechanism in diabetes mellitus distinct from the beta adrenergic receptor. J Clin Invest 52: 870–876PubMedCrossRefGoogle Scholar
  2. 2.
    Malaisse WJ (1972) Hormonal and environmental modification of islet activity. In: Steiner DF, Freinkel N (eds) Endocrine pancreas. American Physiological Society, Washington, pp 237–260 (Handbook of physiology, section 7, vol 1)Google Scholar
  3. 3.
    Malaisse WJ, Sener A, Herchuelz A, Hutton JC, Devis G, Somers G, Blondel B, Malaisse-Lagae F, Orci L (1977) Sequential events in the process of glucose-induced insulin release. In: Bajaj JS (ed) Diabetes. Excerpta Medica, Amsterdam, pp95–102Google Scholar
  4. 4.
    Malaisse WJ, Sener A, Herchuelz A, Hutton JC (1979) Insulin release: the fuel hypothesis. Metabolism 28:373–386PubMedCrossRefGoogle Scholar
  5. 5.
    Malaisse WJ (1984) Insulin release: the fuel concept. Diabète Métab 9: 313–320Google Scholar
  6. 6.
    Matschinsky FM, Ellerman J, Stillings S, Raybaud F, Pace C, Zawalich W (1975) Hexoses and insulin release. In: Hasselblatt A, Bruchhausen Fv (eds) Insulin, part 2. Springer, Berlin Heidelberg New York, pp79–114Google Scholar
  7. 7.
    Sener A, Malaisse WJ (1984) Nutrient metabolism in islet cells. Experientia 40: 1026–1035PubMedCrossRefGoogle Scholar
  8. 8.
    Malaisse WJ, Malaisse-Lagae F, Sener A (1984) Coupling factors in nutrient-induced insulin release. Experientia 40:1035–1043PubMedCrossRefGoogle Scholar
  9. 9.
    Meglasson MD, Matschinsky FM (1984) New perspectives on pancreatic islet glucokinase. Am J Physiol 246: E1–E13PubMedGoogle Scholar
  10. 10.
    Malaisse WJ, Sener A (1985) Glucokinase is not the pancreatic B-cell glucoreceptor. Diabetologia 28:520–527PubMedCrossRefGoogle Scholar
  11. 11.
    Malaisse WJ, Giroix M-H, Malaisse-Lagae F, Sener A (1986) 3-O-methyl-D-glucose transport in tumoral insulin-producing cells. Am J Physiol 251: C841–C846PubMedGoogle Scholar
  12. 12.
    Giroix M-H, Sener A, Malaisse WJ (1986) D-Glucose transport and concentration in tumoral insulin-producing cells. Am J Physiol 251: C847–C851PubMedGoogle Scholar
  13. 13.
    Sener A, Giroix M-H, Malaisse WJ (1986) Impaired uptake of D-glucose by tumoral insulin-producing cells. Biochem Int 12: 913–919PubMedGoogle Scholar
  14. 14.
    Sener A, Malaisse WJ (1985) Resistance to alloxan of tumoral insulin-producing cells. FEBS Lett 193:150–152PubMedCrossRefGoogle Scholar
  15. 15.
    Sener A, Malaisse-Lagae F, Giroix M-H, Malaisse WJ (1986) Sensitivity to pentamidine but resistance to streptozotocin of tumoral insulin-producing cells (RINm5F line). Pancreas 1: 550–555PubMedCrossRefGoogle Scholar
  16. 16.
    Malaisse WJ, Giroix M-H, Sener A (1986) Effect of cytochalasin B upon glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells. Cell Biochem Funct 5:183–187CrossRefGoogle Scholar
  17. 17.
    Malaisse WJ, Sener A, Levy J (1976) The stimulus-secretion coupling of glucose-induced insulin release. XXI. Fasting-induced adaptation of key glycolytic enzymes in isolated islets. J Biol Chem 251:1731–1737PubMedGoogle Scholar
  18. 18.
    Matschinsky FM, Meglasson MD, Burch PT, Berner DK, Najafi H, Vogin AP, Garfinkel D, Garfinkel L (1983) Glucokinase (ATP: D-glucose 6-phosphotransferase E.C. 2.7.1.2), the glucose sensor of pancreatic islet B-cells. In: Mngola EN (ed) Diabetes 1982. Excerpta Medica, Amsterdam, pp337–344 (International congress series 600)Google Scholar
  19. 19.
    Levy J, Herchuelz A, Sener A, Malaisse WJ (1976) The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: a model for altered glucose recognition by the B-cell. Metabolism 25:583–591PubMedCrossRefGoogle Scholar
  20. 20.
    Halban PA, Praz GA, Wollheim CB (1983) Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F). Biochem J 212:439–443PubMedGoogle Scholar
  21. 21.
    Giroix M-H, Sener A, Dufrane SP, Malaisse-Lagae F, Malaisse WJ (1985) Glucose metabolism in insulin-producing tumoral cells. Arch Biochem Biophys 241: 561–570PubMedCrossRefGoogle Scholar
  22. 22.
    Meglasson MD, Burch PT, Hoenig M, Chick WL, Matschinsky FM (1983) Identification and significance of glucokinase in transplantable insulinomas. J Biol Chem 258: 2094–2097PubMedGoogle Scholar
  23. 23.
    Meglasson MD, Matschinsky FM (1984) Purification of the putative islet cell glucose sensor glucokinase from isolated pancreatic islets and insulinoma tissue. In: Larner J, Pohl SL (eds) Methods in diabetes research. Wiley, New York, pp213–226 (vol I: laboratory methods, part B)Google Scholar
  24. 24.
    Malaisse WJ, Malaisse-Lagae F, Sener A, Van Schaftingen E, Hers H-G (1981) Is the glucose-induced stimulation of glycolysis in pancreatic islets attributable to activation of phosphofruc-tokinase by fructose 2,6-bisphosphate? FEBS Lett 125: 217–219PubMedCrossRefGoogle Scholar
  25. 25.
    Malaisse WJ, Malaisse-Lagae F, Sener A (1982) The glycolytic cascade in pancreatic islets. Diabetologia 23:1–5PubMedCrossRefGoogle Scholar
  26. 26.
    Malaisse WJ, Malaisse-Lagae F, Sener A (1982) Glucose-induced accumulation of fructose-2,6-bisphosphate in pancreatic islets. Diabetes 31: 90–93PubMedCrossRefGoogle Scholar
  27. 27.
    Sener A, Malaisse-Lagae F, Malaisse WJ (1982) Glucose-induced accumulation of glucose-1,6-bisphosphate in pancreatic islets: its possible role in the regulation of glycolysis. Biochem Biophys Res Commun 104:1033–1040PubMedCrossRefGoogle Scholar
  28. 28.
    Sener A, Van Schaftingen E, Van De Winkel M, Pipeleers DG, Malaisse-Lagae F, Malaisse WJ, Hers H-G (1984) Effects of glucose and glucagon on the fructose 2,6-bisphosphate content of pancreatic islets and purified pancreatic B-cells. Biochem J 221: 759–764PubMedGoogle Scholar
  29. 29.
    Malaisse-Lagae F, Sener A, Malaisse WJ (1982) Phosphoglucomutase: its role in the response of pancreatic islets to glucose epimers and anomers. Biochimie 64:1059–1063PubMedCrossRefGoogle Scholar
  30. 30.
    Malaisse WJ, Malaisse-Lagae F, Sener A (1983) Anomeric specificity of hexose metabolism in pancreatic islets. Physiol Rev 63: 321–327Google Scholar
  31. 31.
    Giroix M-H, Dufrane SP, Malaisse-Lagae F, Sener A, Malaisse WJ (1984) Fasting-induced impairment of glucose-1,6-bisphosphate synthesis in pancreatic islets. Biochem Biophys Res Commun 119: 543–548PubMedCrossRefGoogle Scholar
  32. 32.
    Idahl L-Å (1973) Dynamics of pancreatic B-cell responses to glucose. Diabetologia 9: 403–412PubMedCrossRefGoogle Scholar
  33. 33.
    Hedeskov CJ, Capito K (1974) The effect of starvation on insulin secretion and glucose metabolism in mouse pancreatic islets. Biochem J 140: 423–433PubMedGoogle Scholar
  34. 34.
    Garvey WT, Olefsky JM, Griffin J, Hamman RF, Kolterman OG (1985) The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes 34: 222–234PubMedCrossRefGoogle Scholar
  35. 35.
    Bolaffi JL, Heidt A, Lewis LD, Grodsky GM (1986) The third phase of in vitro insulin secretion. Evidence for glucose insensitivity. Diabetes 35: 370–373PubMedCrossRefGoogle Scholar
  36. 36.
    Malaisse WJ, Sener A (1987) Interaction between D-glucose and Ca2+ in the priming of the pancreatic B-cell. Diabetes Res 4: 5–8PubMedGoogle Scholar
  37. 37.
    Malaisse-Lagae F, Sener A, Malaisse WJ (1987) Can desensitization of the B-cell to D-glucose be simulated in cultured pancreatic islets? Acta Diab Lat 24: 17–25CrossRefGoogle Scholar
  38. 38.
    Malaisse WJ, Like AA, Malaisse-Lagae F, Gleason RE, Soeldner JS (1968) Insulin secretion in vitro by the pancreas of the sand rat (Psammomys obesus). Diabetes 17: 752–759Google Scholar
  39. 39.
    Malaisse-Lagae F, Ravazzola M, Amherdt M, Gutzeit A, Stauffacher W, Malaisse WJ, Orci L (1975) An apparent abnormality of the B-cell microtubular system in Spiny mice (Acomys cahirinus). Diabetologia 11: 71–76PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

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  • W. J. Malaisse

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