Comparison of the Efficacy and Acceptability of Isosorbide 5-Mononitrate, Isosorbide Dinitrate and Propranolol in the Management of Angina Pectoris
Although isosorbide 5-mononitrate (IS-5-MN) has theoretical advantages over isosorbide dinitrate (ISDN) in terms of metabolism and bioavailability [1–3] there is no conclusive evidence to show that these are reflected in improved therapeutic benefit in clinical practice. A study has therefore been undertaken to compare the efficacy and acceptability of IS-5-MN, ISDN and the beta-adrenoreceptor antagonist propranolol (PROP) in the management of 20 patients with angina pectoris. This is an interim report.
KeywordsPlacebo Depression Propranolol Biotransformation Nitroglycerin
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