Mononitrate II pp 238-241 | Cite as

Comparison of the Efficacy and Acceptability of Isosorbide 5-Mononitrate, Isosorbide Dinitrate and Propranolol in the Management of Angina Pectoris

  • N. A. Irvine
  • D. Maclean
  • D. G. McDevitt
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)


Although isosorbide 5-mononitrate (IS-5-MN) has theoretical advantages over isosorbide dinitrate (ISDN) in terms of metabolism and bioavailability [1–3] there is no conclusive evidence to show that these are reflected in improved therapeutic benefit in clinical practice. A study has therefore been undertaken to compare the efficacy and acceptability of IS-5-MN, ISDN and the beta-adrenoreceptor antagonist propranolol (PROP) in the management of 20 patients with angina pectoris. This is an interim report.


Angina Pectoris Intermittent Claudication Interim Report Isosorbide Dinitrate Anginal Attack 
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  1. 1.
    Down WH, Chassaud LF, Grundy RK (1974) Biotransformation of isosorbide dinitrate in humans. J Pharm Sci 63: 1147–1149PubMedCrossRefGoogle Scholar
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    Abshagen U, Sporl-Radnn S (1980) Pharmacokinetics and effect of 5-isosorbide mononitrate (5IS-5-MN) in normal man. In: World conference on clinical pharmacology and therapeutics. MacMillan, London, p.0377Google Scholar
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    Abshagen U, Betzien G, Endele R, Kaufmann B (1981) Pharmacokinetics of intravenous and oral isosorbine-5-mononitrate. Eur J Clin Pharmacol 20: 269–275PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • N. A. Irvine
  • D. Maclean
  • D. G. McDevitt

There are no affiliations available

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