Zusammenfassung
Humane epidermale Zellen (EZ) sind potente Stimulatoren der antigenspezifischen allogenen T-Lymphozyten-Aktivierung. Diese funktionelle Eigenschaft beruht auf die Anwesenheit von Klasse II-Alloantigen tragenden Langerhans-Zellen [8]. Es gibt zwischenzeitlich zahlreiche Hinweise, daß bei vielen Dermatosen Keratinozyten ebenfalls HLA-DR-Antigen exprimieren können [4]. Es wurde außerdem mitgeteilt, daß Interferon-γ (IFN-γ) in der Lage ist, HLA-DR-Synthese und Expression bei gezüchteten normalen humanen Keratinozyten zu bewirken [9].
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Literatur
Breard J, Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1980) A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol 124: 1143–1146
Csató M, Bozóky B, Hunyadi J, Dobozy A (1986) Candida albicans phagocytosis by separated human epidermal cells. Arch Derm Res 279: 136–139
Eisinger M, Soo Lee JI, Hefton JM, Darzynkiewicz Z, Chiao JW, De Harven E (1979) Human epidermal cell cultures: growth and differentiation in the absence of dermal components or medium supplements. Proc Natl Acad Sci 76: 5340–5344
Lampert IA (1984) Expression of HLA-DR (Ia like) antigen on epidermal keratinocytes in human dermatoses. Clin Exp Immunol 57: 93–100
Scheynius A, Tjernlund U (1984) Human keratinocytes express HLA-DR antigens in the tuberculin reaction. J Invest Dermatol 82: 559
Shen HH, Talle MA, Goldstein G, Chess L (1983) Functional subsets of monocytes defined by monoclonal antibodies: a distinct subset of monocytes contains the cells capable of inducing the autologous mixed lymphocyte culture. J Immunol 130: 698–705
Simon jr M, Hunyadi J (1987) Expression of OKM5 antigen on human keratinocytes in positive intracutaneous tests for delayed-type hypersensitivity. Dermatologica (in press)
Van Voorhis WC, Valinski J, Hoffmann E, Luban J, Hair LS, Steinman RM (1983) Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J Exp Med 158: 174–191
Volc-Platzer B, Leibl H, Luger T, Zahn G, Stingl G (1985) Human epidermal cells synthesize HLA-DR alloantigens in vitro upon stimulation with γ-interferon. J Invest Dermatol 85: 16–19
Yoneda K, Volc-Platzer B, Binder A, Wolff K, Stingl G (1986) Human epidermal cells as accessory cells in mitogen-driven T cell proliferation. J Invest Dermatol 86: 326
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© 1987 Springer-Verlag Berlin Heidelberg
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Simon, M., Hunyadi, J. (1987). Expression von OKM5 Antigen an humanen Keratinozyten in vitro nach Stimulation mit Gamma-Interferon. In: Holzmann, H., Altmeyer, P., Marsch, W.C., Vogel, H.G. (eds) Dermatologie und Rheuma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72668-2_58
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