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Expression von OKM5 Antigen an humanen Keratinozyten in vitro nach Stimulation mit Gamma-Interferon

  • M. SimonJr
  • J. Hunyadi
Conference paper

Zusammenfassung

Humane epidermale Zellen (EZ) sind potente Stimulatoren der antigenspezifischen allogenen T-Lymphozyten-Aktivierung. Diese funktionelle Eigenschaft beruht auf die Anwesenheit von Klasse II-Alloantigen tragenden Langerhans-Zellen [8]. Es gibt zwischenzeitlich zahlreiche Hinweise, daß bei vielen Dermatosen Keratinozyten ebenfalls HLA-DR-Antigen exprimieren können [4]. Es wurde außerdem mitgeteilt, daß Interferon-γ (IFN-γ) in der Lage ist, HLA-DR-Synthese und Expression bei gezüchteten normalen humanen Keratinozyten zu bewirken [9].

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. SimonJr
  • J. Hunyadi

There are no affiliations available

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