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Dermatologie und Rheuma pp 430–443Cite as

Zytostatika, Immunsuppressiva, Immunmodulatoren — aus dermatologischer Sicht

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Zusammenfassung

Eine genaue Trennung der vorgegebenen Begriffe Zytostatika, Immunsuppressiva und Immunmodulatoren ist wegen der sich überschneidenden Wirkungen der Medikamente kaum zu geben. Unter Zytostatika verstehen wir Substanzen, die Zellwachstum und Zellteilung verhindern. Wirken derartige Substanzen vorherrschend auf Zellen des Immunsystems, so wird der Begriff Immunsuppressivum verwendet. Die Modulatoren des Immunsystems, die Immunmodulatoren, umfassen eine unübersehbare Vielzahl von chemischen Substanzen wie Hemmer der Cyclooxygenase und Lipoxygenase (z.B. Acetylsalicylsäure, nichtsteroidale Antiphlogistika), Antihistaminika und H-2-Blocker. Aber auch physiologische Substanzen, die bei einer Immunreaktion freigesetzt werden, wie Interferon, Interleukine und andere Lymphokine. Eine zufriedenstellende Einteilung ist somit auch nicht zu geben. Die in Tabelle 1 gegebene Einteilung ist ein Einteilungsversuch, wobei die Schwerpunkte auf die hier abgehandelten, vorherrschend bei Dermatosen mit einer (Auto)Immunpathogenese zur Anwendung kommenden Medikamente berücksichtigt werden.

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Authors
  1. G. Goerz
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Editors and Affiliations

  1. Zentrum der Dermatologie und Venerologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 6000, Frankfurt 70, Deutschland

    Hans Holzmann  & Wolfgang Christian Marsch  & 

  2. Dermatologische Klinik, Universitäts-Klinikum der Ruhr-Universität St. Josef-Hospital, Gudrunstraß56, 4630, Bochum, Deutschland

    Peter Altmeyer

  3. Hoechst AG Pharma Forschung, Postfach 800320, 6230, Frankfurt 80, Deutschland

    H. Gerhard Vogel

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Goerz, G. (1987). Zytostatika, Immunsuppressiva, Immunmodulatoren — aus dermatologischer Sicht. In: Holzmann, H., Altmeyer, P., Marsch, W.C., Vogel, H.G. (eds) Dermatologie und Rheuma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72668-2_40

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