Skip to main content

Genetik der Sklerodermien

  • Conference paper
Dermatologie und Rheuma

Zusammenfassung

Die Ätiologie der zirkumskripten Sklerodermie (ZS) und der progressiven systemischen Sklerodermie (PSS) ist weitgehend unbekannt. Der einzige ätiologische Hinweis ist die nachgewiesene Assoziation beider Sklerodermieformen mit teilweise identischen HLA-Markern (s. Kühnl et al.: Immungenetik, S. 99). Eine genetische Verankerung der Sklerodermie ist somit anzunehmen [12].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ablonczy E, Horváth A, Imregh E (1984) Familiär vorkommende Sklerodermie. Börgyógy Vener Szle 60: 217–221

    Google Scholar 

  2. Barnett AL (1974) Scleroderma (progressive systemic sclerosis). Thomas, Springfield

    Google Scholar 

  3. Bernstein R, Prinsloo I, Zwi S, Andrew MJA, Dawson B, Jenjins T (1980) Chromosomal aberrations in occupation-associated progressive systemic sclerosis. S Afr Med J 58: 235–237

    PubMed  CAS  Google Scholar 

  4. Bianchi FA, Bistue AR, Wendt VE, Puro HE, Keech MK (1966) Analysis of twenty-seven cases of progressive systemic sclerosis (including two with combined systemic lupus erythematosus) and a review of the literature. J Chron Dis 19: 953–977

    Article  PubMed  CAS  Google Scholar 

  5. Cantwell AR Jr, Craggs E, Wilson JW, Swatek F (1968) Acid-fast bacteria as a possible cause of scleroderma. Dermatologica 136: 141–150

    Article  PubMed  Google Scholar 

  6. Cantwell AR Jr, Kelso DW (1971) Acid-fast bacteria in scleroderma and morphea. Arch Dermatol 104: 21–25

    Article  PubMed  Google Scholar 

  7. Cantwell AR Jr, Kelso DW, Rowe L (1979) Hypodermitis sclerodermiformis and unusual acid-fast bacteria. Arch Dermatol 115: 449–452

    Article  PubMed  Google Scholar 

  8. Cantwell AR Jr, Kelso DW (1980) Autopsy findings of nonacid-fast bacteria in scleroderma. Dermatologica 160: 90–99

    Article  PubMed  Google Scholar 

  9. Chauvet M, Martin E (1964) Silicose et sclérodermic Schweiz Med Wschr 4: 1261–1263

    Google Scholar 

  10. Chorzelski T, Jablonska S (1979) Coexistence of lupus erythematosus and scleroderma in light of immunopathological investigations. Acta Dermatovener 50: 81–85

    Google Scholar 

  11. Crouzet J, Marbach MC, Camus JP (1975) Recherche d’une association entre antigenes HLA et sclerodermic systémique. La Nouvelle Presse Med 4: 2489–2492

    CAS  Google Scholar 

  12. Dausset J (1977) Clinical implications (nosology, diagnosis, prognosis and preventive therapy). In: Dausset J, Svejgaard A (eds) HLA and disease. Munksgaard, Copenhagen, S 296–310

    Google Scholar 

  13. Delmotte N, Van der Meiren L (1953) Recherches bactériologiques et histologiques concernant la sclérodermic Dermatologica 107: 177–182

    CAS  Google Scholar 

  14. Emerit I, Levy A, Housset E (1974) Breakage factor in systemic sclerosis and protector effect of L-cysteinc Humangenetik 25: 221–226

    CAS  Google Scholar 

  15. Flores RH, Stevens MB, Arnett FC (1984) Familial occurrence of progressive systemic sclerosis and systemic lupus erythematosus. J Rheumatol 11: 321–323

    PubMed  CAS  Google Scholar 

  16. Frayha RA, Tabbara KF, Geha RS (1977) Familial CREST-syndrome with sicca complex. J Rheumatol 4: 53–58

    PubMed  CAS  Google Scholar 

  17. Gershwin ME, Abplanalp H, Castles JJ, Ikeda RM, Van der Water J, Eklund J, Haynes D (1981) Characterisation of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma). J Exp Med 153: 1640–1659

    Article  PubMed  CAS  Google Scholar 

  18. Greger RE (1975) Familial progressive systemic scleroderma. Arch Dermatol 111: 81–85

    Article  PubMed  CAS  Google Scholar 

  19. Hashimoto K (1970) Paramyxovirus-like inclusions in so-called collagen and autoimmune diseases. Prog Dermatol 5:1–4

    Google Scholar 

  20. Haustein UF (1973) Tubular structures in affected and normal skin in chronic discoid and systemic lupus erythematosus: electron-microscopic studies. Br J Dermatol 89: 1–13

    Article  PubMed  CAS  Google Scholar 

  21. Haustein UF, Ziegler V (1986) Sklerodermie und sklerodermieähnliche Erkrankungen durch Umweltsubstanzen. Dermatosen 34: 61–67

    CAS  Google Scholar 

  22. Ishikawa H, Saito Y, Yamakage A, Kitabatake M (1978) Sclerodermainducing glycosaminoglycan in the urine of patients with systemic scleroderma. Dermatologica 156: 193–204

    Article  PubMed  CAS  Google Scholar 

  23. Kass H, Hanson V, Patrick J (1966) Scleroderma in childhood. J Pediatr 68: 243–256

    Article  Google Scholar 

  24. Korting GW, Holzmann H (1967) Die Sklerodermie und ihr nahestehende Bindegewebsprobleme. Thieme, Stuttgart

    Google Scholar 

  25. Kudejko J (1966) Virus-like particles observed in the striated muscles in patients with acroscleroderma. Dermatologica 133: 495–502

    Article  PubMed  CAS  Google Scholar 

  26. Kühnl P, Schütz K, Altmeyer P, Holzmann H, Seidl S (1985) Assoziation von HLA-Antigenen und Sklerodermie. Z Hautkr 60: 866–868

    PubMed  Google Scholar 

  27. Leonhardt T (1961) Familial occurrence of collagen diseases. II Progressive systemic sclerosis and dermatomyositis. Acta Med Scand 169: 735–742

    Article  PubMed  CAS  Google Scholar 

  28. Mackel SE, Kozin F, Ryan LM, Sheth KJ, Jordan RE (1979) Concurrent linear scleroderma and systemic lupus erythematosus: a report of two cases. J Invest Dermatol 73: 368–372

    Article  PubMed  CAS  Google Scholar 

  29. Masi AT, D’Angelo WA (1967) Epidemiology of fatal systemic sclerosis (diffuse scleroderma). A 15-year survey in Baltimore. Ann Intern Med 66: 870–883

    PubMed  CAS  Google Scholar 

  30. McKusick VA (1969) Human Genetics, 2nd edn. Prentice-Hall, Englewood Cliffs

    Google Scholar 

  31. Meinhof W (1974) Progressive Sklerodermie vom Akrosklerose-Typ bei Mutter und Tochter mit multiplen Hauttumoren bei der Mutter. Z Hautkr 49: 653–660

    PubMed  CAS  Google Scholar 

  32. Menton DB, Hess RA (1980) The ultrastructure of collagen in the dermis of tight-skin (TSK) mutant mice. J Invest Dermatol 74: 139–147

    Article  PubMed  CAS  Google Scholar 

  33. Mitchell AJ, Rusin LJ, Diaz LA (1980) Circumscribed scleroderma with immunologic evidence of systemic lupus erythematosus. Report of a case and review of the literature. Arch Dermatol 116: 69–73

    Article  PubMed  CAS  Google Scholar 

  34. Muehrcke RC (1957) Lupus nephritis. Williams and Wilkins, Baltimore

    Google Scholar 

  35. Mund DJ, Greenwald RA (1978) The CREST syndrome variant of scleroderma in a mother-daughter pair. J Rheumatol 5: 307–310

    PubMed  CAS  Google Scholar 

  36. Muralidar K, Siddaraj KS, Sankaran K, Gupta GD (1978) Familial scleroderma. J Asso Phys Ind 26: 307–310

    CAS  Google Scholar 

  37. Ohtaki N, Miyamoto C, Orita M, Koya M, Matsuo M (1986) Concurrent multiple morphea and neonatal lupus erythematosus in an infant boy born to a mother with SLE. Br J Dermatol 115: 85–90

    Article  PubMed  CAS  Google Scholar 

  38. Rendall JR, McKenzie AB (1974) Familial scleroderma. Br J Dermatol 91: 517–522

    Article  PubMed  CAS  Google Scholar 

  39. Rook A, Wilkinson DS, Ebling FJG (eds) (1979) Textbook of dermatology. Blackwell Scientific Publications, Oxford London Edinburgh Melbourne

    Google Scholar 

  40. Rose T, Nothjunge J, Schlote W (1985) Familial occurrence of dermatomyositis and progressive scleroderma after injection of a local anaesthetic for dental treatment. Eur J Pediatr 143: 225–228

    Article  PubMed  CAS  Google Scholar 

  41. Rowell NR (1962) Lupus erythematosus cells in systemic sclerosis. An Rheum Dis 21: 70–75

    Article  CAS  Google Scholar 

  42. Sasaki S, Yoshino H (1977) Systemic scleroderma in mother and daughter. Arch Dermatol 113: 378–379

    Article  PubMed  CAS  Google Scholar 

  43. Sherer GK, Jackson BB, Leroy EC (1981) Chromosome breakage and sister chromatid exchange frequencies in scleroderma. Arthritis Rheum 24: 1409–1413

    Article  PubMed  CAS  Google Scholar 

  44. Soppi E, Lehtonen A, Torvanen A (1982) Familial progressive systemic sclerosis (scleroderma): immunological analysis of two patients and six siblings form a single kindred. Clin Exp Immunol 50: 275–282

    PubMed  CAS  Google Scholar 

  45. Spühler O, Morandi C (1949) Sklerodermie und ihre Beziehungen zu Libman-Sacks-Syndrom, Dermatomyositis und rheumatischem Infektionskreis. Helvet Med Acta 16: 147–163

    PubMed  Google Scholar 

  46. Sternberg EM, Van Woert MH, Young SN, Magnussen I, Baker H, Gauthier S, Osterland K (1980) Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 303: 782–787

    Article  PubMed  CAS  Google Scholar 

  47. Strosberg JM, Peck B, Harris ED (1977) Scleroderma with intestinal involvement: fatal in two of a kindred. J Rheumatol 4: 46–52

    PubMed  CAS  Google Scholar 

  48. Svejgaard A, Platz P, Ryder LP (1983) HLA and disease 1982-a survey. Immunological Rev 70: 193–218

    Article  CAS  Google Scholar 

  49. Sverdrup B (1984) Do workers in the manufacturing industry run an increased risk of getting scleroderma? Intern J Dermatol 23: 629

    Article  CAS  Google Scholar 

  50. Taj M, Ahmad A (1977) Familial localized scleroderma (morphea). Arch Dermatol 113: 1132–1133

    Article  PubMed  CAS  Google Scholar 

  51. Takehara K, Moroi Y, Ishibashi Y (1985) Antinuclear antibodies in the relatives of patients with systemic sclerosis. Br J Dermatol 112: 23–33

    Article  PubMed  CAS  Google Scholar 

  52. Thürlimann W, Harms M (1982) Sklerodermiforme Veränderungen nach PUVA-Therapie bei Vitiligo. Dermatologica 164: 305–313

    Article  PubMed  Google Scholar 

  53. Tuffanelli DL, Winkelmann RK (1962) Scleroderma and its relationship to the collagenoses: lupus erythematosus, dermatomyositis, rheumatoid arthritis, and Sjögren’s syndrome. Amer J Med Sci 1078: 133–146

    Google Scholar 

  54. Tuffanelli DL, Marmelzat WL, Dorsey CS (1966) Linear scleroderma with hemiatrophy: report of three cases associated with collagenvascular disease. Dermatologica 132: 52–58

    Article  Google Scholar 

  55. Umbert P, Winkelmann RK (1978) Concurrent localized scleroderma and discoid lupus erythematosus, cutaneous “mixed” or “overlap” syndrome. Arch Dermatol 114: 1473–1478

    Article  PubMed  CAS  Google Scholar 

  56. Van Rhee R (1927) Morphea in sisters. Arch Derm Syph 15: 609

    Google Scholar 

  57. Weidner F, Braun-Falco O (1968) Gleichzeitiges Vorkommen von Symptomen der circumscripten und progressiven Sklerodermie. Hautarzt 19: 345–350

    PubMed  CAS  Google Scholar 

  58. Wendt GG (1966) Allgemeine Humangenetik. In: Gottron HA, Schnyder UW (Hrsg) Vererbung von Hautkrankheiten VII. Springer, Berlin Heidelberg New York (Handbuch der Haut- und Geschlechtskrankheiten, Ergänzungswerk, Bd VII, S 1–130)

    Google Scholar 

  59. Wuerthele-Caspé V (1947) Etiology of scleroderma, preliminary clinical report. J Med Soc New Jersey 44: 256–259

    PubMed  Google Scholar 

  60. Wuthrich RC, Henry HR, Willard DS (1975) Localized scleroderma. A report of two families. Arch Dermatol 111: 98–104

    Article  PubMed  CAS  Google Scholar 

  61. Yamakage A, Ishikawa H (1982) Generalized morphea-like scleroderma occurring in people exposed to organic solvents. Dermatologica 165: 186–193

    Article  PubMed  CAS  Google Scholar 

  62. Ziegler V, Haustein UF, Mehlhorn J, Münzberger H, Rennau H (1986) Quarzinduzierte Sklerodermie. Sklerodermie-ähnliches Syndrom oder echte progressive Sklerodermie? Dermatol Monatsschr 172: 86–90

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sollberg, S., Holzmann, H. (1987). Genetik der Sklerodermien. In: Holzmann, H., Altmeyer, P., Marsch, W.C., Vogel, H.G. (eds) Dermatologie und Rheuma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72668-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72668-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72669-9

  • Online ISBN: 978-3-642-72668-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics