Mapping of Evoked Potentials in Normals and Patients with Psychiatric Diseases

  • K. Maurer
  • T. Dierks
  • R. Ihl
  • G. Laux


Studies on the clinical use of evoked potentials (EP) in psychiatry date back to the mid-1960s, when Callaway et al. (1965) and Rodin et al. (1964) described EP alterations in schizophrenia. The first book about the use of EP in psychiatry appeared in 1972 (Shagass 1972). The most consistent finding in the following studies by Roth etal. (1981) and Pfefferbaum et al. 1984 b) was a reduction of P300 amplitudes in schizophrenia and dementia. For schizophrenia, this reduction seemed to be the most robust and replicable waveform alteration indicating biological deficits in this disease. Despite all these valuable results, the EP method did not gain the degree of clinical significance that would have been necessary for routine use of EP for differential diagnosis and drug monitoring. One reason might be the nonspecificity of EP alterations, which are often similar in different diseases.


Visual Evoke Potential P300 Amplitude Arachnoidal Cyst Evoke Potential Somatosensory Evoke Potential 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. Maurer
  • T. Dierks
  • R. Ihl
  • G. Laux
    • 1
  1. 1.Department of PsychiatryUniversity of WürzburgWürzburgFederal Republic of Germany

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