The Neuropsychology of Schizophrenia in the Context of Topographical Mapping of Electrocortical Activity

  • J. Gruzelier
  • D. Liddiard


A preliminary study with EEG topographical mapping in carefully characterised schizophrenic patients will be reported in which patients were clearly differentiated from controls. The majority of test conditions involved functional activation with neuropsychological tests validated on neurological patients. Group differences were seldom found in the resting EEG. Before describing the results other reports using new EEG imaging procedures will be outlined and some contemporary approaches to the investigation of central nervous system dysfunction in schizophrenia will be briefly reviewed.


Schizophrenic Patient Frontal Delta Central Nervous System Dysfunction Compute Tomography Sign Lateral Asymmetry 
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  1. Andrews HB, Honse AO, Cooper JE, Barber C (1986) The prediction of abnormal evoked potentials in schizophrenic patients by means of symptom pattern. Br J Psychol 149:46–50CrossRefGoogle Scholar
  2. Andrews HB, Barber C, Cooper JE, Raine A (1987) Early somatosensory evoked potentials in schizophrenia: symptom pattern, clinical outcomes and interhemispheric functioning. In: Takahashi R, Flor-Henry P, Gruzelier J, Niwa SI (eds) Cerebral dynamics, laterality and psychopathology. Elsevier, Amsterdam, pp 175–186Google Scholar
  3. Annett M (1970) Classification of hand preference by association analysis. Br J Psychol 61:303–321PubMedCrossRefGoogle Scholar
  4. Bleuler E (1950) Dementia praecox or the group of schizophrenias. New York International University Press, New York (translated from 1911 original)Google Scholar
  5. Bragina NN (1966) Clinical syndromes of disorders of the hippocampus and adjacent areas of the brain. Klin Med (Mosk) 44:23–27Google Scholar
  6. Buchsbaum MS, King AC, Cappelletti J, Coppola R, van Kammen DP (1982) Visual evoked potential topography in patients with schizophrenia and normal controls. Adv Biol Psychiatry 9:50–56Google Scholar
  7. Bull HC, Venables PH (1974) Speech perception in schizophrenia. Br J Psychiatry 125:350–354PubMedCrossRefGoogle Scholar
  8. Cohen G (1982) Theoretical interpretations of lateral asymmetries. In: Beaumont JG (ed) Divided visual field studies of cerebral organisation. Academic, New York, pp 87–115Google Scholar
  9. Connolly JF, Gruzelier JH (1982) A critical examination of augmenting/reducing methodology in schizophrenic patients and controls. In: Langnau ED (ed) Advances in biological psychiatry, vol 9. Karger, BaselGoogle Scholar
  10. Crow TJ (1980) Molecular pathology of schizophrenia: more than one disease process? Br Med J 280:66–68PubMedCrossRefGoogle Scholar
  11. Cummings JL, Benson DF (1984) Subcortical dementia: review of an emerging concept. Arch Neurol 41:874–879PubMedCrossRefGoogle Scholar
  12. Davison K, Bagley CR (1969) Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. In: Herrington RN (ed) Current problems in neuropsychiatry. Royal Medico-Psychological Association, LondonGoogle Scholar
  13. Dimond SJ, Beaumont JG (1973) Difference in vigilance performance of the right and left hemisphere. Cortex 9:259–265PubMedGoogle Scholar
  14. Flor-Henry P (1969) Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia 10:363–395PubMedCrossRefGoogle Scholar
  15. Flor-Henry P (1974) Psychosis, neurosis and epilepsy. Br J Psychiatry 124:144–150PubMedCrossRefGoogle Scholar
  16. Flor-Henry P (1983) Cerebral basis of psychopathology. Wright, New YorkGoogle Scholar
  17. Flor-Henry P, Yeudal LG (1979) Neuropsychological investigation of schizophrenia and manic-depressive psychoses. In: Gruzelier J, Flor-Henry P (eds) Hemisphere asymmetry of function and psychopathology. Elsevier/North Holland Biomedical, Amsterdam, pp 341–362Google Scholar
  18. Franzen G, Ingvar DH (1975) Abnormal distribution of cerebral activity in chronic schizophrenia. J Psychiatr Res 12:199–214PubMedCrossRefGoogle Scholar
  19. Friedman D (1987) The endogenous scalp-recorded brain potentials in schizophrenia. In: Stein-hauer S, Gruzelier JH, Zubin J (eds) Experimental psychopathology, neuropsychology & psychophysiology. Elsevier Science, Amsterdam (Handbook of schizophrenia, vol 4Google Scholar
  20. Gaebel W, Ulrich G, Frick K (1986) Eye-movement research with schizophrenic patients and normal controls using corneal reflection-pupil centre measurement. Eur Arch Psychiatry Neurol Sci 235:243–254PubMedCrossRefGoogle Scholar
  21. Gibbs FA, Gibbs EL (1961) Clinical and pharmacological correlates of fast activity in electroencephalography. J Neuropsychiatry 3:73–78Google Scholar
  22. Gruzelier JH (1973) Bilateral asymmetry of skin conductance orienting activity and levels with schizophrenics. Biol Psychol 1:21–41PubMedCrossRefGoogle Scholar
  23. Gruzelier JH (1983) A critical assessment and integration of lateral asymmetries in schizophrenia. In: Myslobodsky MS (ed) Hemisyndromes, psychobiology, neurology and psychiatry. Academic, New York, pp 265–326Google Scholar
  24. Gruzelier JH (1984) Hemispheric imbalances in schizophrenia. Int J Psychophysiol 1:227–240PubMedCrossRefGoogle Scholar
  25. Gruzelier JH (1987 a) Commentary on neuropsychological information processing deficits in psychosis and neuropsychophysiological syndrome relationships in schizophrenia. In: Taka-hashi R, Flor-Henry P, Gruzelier J, Niwa S (eds) Cerebral dynamics, laterality and psycho-pathology. Elsevier Science, Amsterdam, pp 23–54Google Scholar
  26. Gruzelier JH (1987) Cerebral laterality in schizophrenia: a review of the interhemispheric disconnection hypothesis. In: Glass A (ed) Individual differences in hemispheric specialisation. Plenum, London, pp 357–376Google Scholar
  27. Gruzelier JH (1987) Individual differences in dynamic process asymmetries in the normal and pathological brain. In: Glass A (ed) Individual differences in hemispheric specialisation. Plenum, London, 301–330Google Scholar
  28. Gruzelier JH, Manchanda R (1982) The syndrome of schizophrenia: relations between electro-dermal response, lateral asymmetries and clinical subtypes. Br J Psychiatry 141:488–495PubMedCrossRefGoogle Scholar
  29. Gruzelier JH, Venables PH (1972) Skin conductance orienting activity in a heterogeneous sample of schizophrenics: possible evidence of limbic dysfunction. J Nervous Ment Dis 155:277–287CrossRefGoogle Scholar
  30. Gruzelier JH, Venables PH (1973) Skin conductance responses to tones with and without attentional significance in schizophrenic and non-schizophrenic patients. Neuropsychologia 11:221–230PubMedCrossRefGoogle Scholar
  31. Gruzelier JH, Venables PH (1974) Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenics: replication and evidence of lateral asymmetry in patients with depression and disorders of personality. Biol Psychiatry 8:55–73PubMedGoogle Scholar
  32. Gruzelier J, Wilson L (1987) The hemisphere imbalance syndrome rating scale (in preparation)Google Scholar
  33. Gruzelier JH, Jutai J, Connolly JF, Hirsch SR (1985) Cerebral asymmetries in unmedicated schizophrenic patients in EEG spectra and their relation to clinical and autonomic parameters. Adv Biol Psychiatry 15:12–19Google Scholar
  34. Gruzelier J, Seymour K, Wilson L, Jolley A, Hirsch S (1987) Neuropsychological evidence for hippocampal and frontal impairments in schizophrenia, mania and depression. In: Takahashi R, Flor-Henry P, Gruzelier J, Niwa S (eds) Cerebral dynamics, laterality and psychopathology. Elsevier Science, Amsterdam, pp 273–286Google Scholar
  35. Günther W, Breitling D (1985) Predominant sensorimotor area left hemisphere dysfunction in schizophrenia measured by brain electrical activity mapping. Biol Psychiatry 20:515–532CrossRefGoogle Scholar
  36. Günther W, Breitling D, Banquet JP, Marcie P, Rondot P (1986) EEG mapping of left hemisphere dysfunction during motor performance in schizophrenia. Biol Psychiatry 21:249–262CrossRefGoogle Scholar
  37. Gur RE, Skolnik BE, Gur RC et al (1983) Brain function in psychiatric disorders. Arch Gen Psychiatry 40:1250–1254PubMedCrossRefGoogle Scholar
  38. Ingvar DH, Franzen G (1974) Abnormalities of cerebral bloodflow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 50:425–462PubMedCrossRefGoogle Scholar
  39. Johnstone EC, Crow TJ, Frith CD, Husband J, Kreell (1978) The dementia of dementia praecox. Acta Psychiatr Scand 57:305–324PubMedCrossRefGoogle Scholar
  40. Jutai J, Gruzelier JH, Connolly J, Manchanda R, Hirsch SR (1984) Schizophrenia ad spectral analysis of the visual evoked potential. Br J Psychiatry 145:496–501PubMedCrossRefGoogle Scholar
  41. Karson CN, Coppola R, Morihisa JM, Weinberger DR (1987) Computed electroencephalo-graphic activity mapping in schizophrenia. Arch Gen Psychiatry 44:514–517PubMedCrossRefGoogle Scholar
  42. Kaufman L, Williamson SJ (1982) Magnetic location of cortical activity. Ann Ny Acad Sci 388:197–213PubMedCrossRefGoogle Scholar
  43. Kety SS (1980) The syndrome of schizophrenia: unresolved questions and opportunities for research. Br J Psychiatry 136:421–436PubMedCrossRefGoogle Scholar
  44. Kinsbourne M (1982) Hemispheric specialisation and the growth of human understanding. Am Psychol 37:411–420PubMedCrossRefGoogle Scholar
  45. Kolb B, Whishaw I (1983) Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal or parietal function in neurological patients. J Nerv Ment Dis 171:435–443PubMedCrossRefGoogle Scholar
  46. Kraepelin EE (1896) Lehrbuch der Psychiatric Barth, LeipzigGoogle Scholar
  47. Malamud N (1967) Psychiatric disorders with intracranial tumours of the limbic system. Arch Neurol 17:113–123PubMedCrossRefGoogle Scholar
  48. Matthyssee S, Spring BG, Sugarman J (eds) (1978) Attention and information processing in schizophrenia. J Psychiatr Res 14:133Google Scholar
  49. Mesulam M (1981) A cortical network for directed attention and unilateral neglect. Ann Neurol 10:309–325PubMedCrossRefGoogle Scholar
  50. Mesulam MM, Geschwind N (1978) On the possible role of neocortex and its limbic connections in the process of attention and schizophrenia. J Psychiatr Res 14:249–260PubMedCrossRefGoogle Scholar
  51. Milner B (1971) Interhemispheric differences in the localisation of psychological processes in man. Br Med Bull 27:272–277PubMedGoogle Scholar
  52. Morihisa JM, Duffy FH, Wyatt RJ (1983) Brain electrical activity mapping (BEAM) in schizophrenic patients. Arch Gen Psychiatry 40:719–728PubMedCrossRefGoogle Scholar
  53. Morstyn R, Duffy FH, McCarley RW (1983) Computed P300 topography in schizophrenia. Electroencephalogr Clin Neurophysiol 40:729–734Google Scholar
  54. Newlin DB, Carpenter B, Golden J (1981) Hemispheric asymmetries in schizophrenia. Biol Psychiatry 16:561–582PubMedGoogle Scholar
  55. Petsche H, Pockberger H, Rappelsberger P (1985) EEG topography and mental performance. In: Duffy FH (ed) Topographic mapping of brain electrical activity. Butterworth, LondonGoogle Scholar
  56. Petrides M (1985) Deficits on conditional associative-learning tasks after frontal lobe and temporal lobe lesions in man. Neuropsychologia 23:601–614PubMedCrossRefGoogle Scholar
  57. Pribram KH, McGuinness D (1975) Arousal, activation and effort in the control of attention. Psychol Rev 82:116–147PubMedCrossRefGoogle Scholar
  58. Reynolds GP (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenics. Nature 305:527–529PubMedCrossRefGoogle Scholar
  59. Reynolds GP, Czudek C (1987) Neurochemical laterality of the limbic system in schizophrenia. In: Takahashi R, Flor-Henry P, Gruzelier J, Niwa S (eds) Cerebral dynamics, laterality and psychopathology. Elsevier Science, Amsterdam, pp 451–456Google Scholar
  60. Rosenthal R, Bigelow LB (1972) Quantitative brain measurements in chronic schizophrenia. Br J Psychiatry 121:259–264PubMedCrossRefGoogle Scholar
  61. Sackheim HA, Greenberg MS, Wynman AL et al (1982) Hemispheric asymmetry in the expression of positive and negative emotions: neurological evidence. Arch Neurol 39:210–218CrossRefGoogle Scholar
  62. Shagass C (1977) Early evoked potentials. Schizophr Bull 3:80–92PubMedGoogle Scholar
  63. Sheppard G, Gruzelier JH, Manchanda R, Hirsch SR, Wise R, Frackowiak R, Jones T (1983) 15–0 positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. The Lancet 2:1448–1452CrossRefGoogle Scholar
  64. Smythies JR (1969) The behavioural physiology of the temporal lobe. In: Herrington RN (ed) Current problems in neuropsychiatry. Royal Medico-Psychological Association, LondonGoogle Scholar
  65. Torrey EF, Peterson MR (1974) Schizophrenia and the limbic system. Lancet 2:942–946PubMedCrossRefGoogle Scholar
  66. Tucker DM, Williamson PA (1984) Asymmetric neural control systems in human self-regulation. Psychol Rev 91:185–215PubMedCrossRefGoogle Scholar
  67. Venables PH (1964) Input dysfunction in schizophrenia. In: Mahar B (ed) Advances in experimental personality research, vol 1. Academic, New YorkGoogle Scholar
  68. Walker E, McGuire S (1982) Intra- and inter-hemispheric information processing in schizophrenia. Psychol Bull 92:701–725PubMedCrossRefGoogle Scholar
  69. Warrington EK (1984) Recognition memory test manual. NFER-Nelson, WindsorGoogle Scholar
  70. Weinberger DR, Burman KF, Zee RF (1986) Physiologic dysfunction of dorso-lateral prefrontal cortex in schizophrenia. I. Regional cerebral bloodflow evidence. Arch Gen Psychiatry 43:114–124PubMedCrossRefGoogle Scholar
  71. Wexler BE (1980) Cerebral laterality and psychiatry: a review of the literature. Am J Psychiatry 137:279–291PubMedCrossRefGoogle Scholar
  72. Wing JK, Cooper JE, Sartorius N (1974) The measurement and classification of psychiatric symptoms. Cambridge University Press, LondonGoogle Scholar
  73. Wood CC, Allison T, Goff WR (1980) On the neural origin of P300 in man. Prog Brain Res 54:51–56PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Gruzelier
  • D. Liddiard
    • 1
  1. 1.Department of PsychiatryCharing Cross & Westminster Medical SchoolLondonUK

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