Summary
An inhibitor of protein synthesis is activated in reticulocytes and in their lysates under high p02. This activation is enhanced by ATP and prevented by glucose-6-phosphate or high concentrations of cAMP. With an apparent molecular weight of about 2.3kD, the high p02 inhibitor is distinct from the hemin-regulated inhibitor (HRI), but, possibily identical with a glutathione disulphide-dependent inhibitor. This inhibitor is a likely component of the cascade system which,through activation of HRI, gives rise to phosphorylation of eukaryotic initiation factor 2 and to inhibition of globin synthesis.
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References
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Bermek, E., Bolumu, B. (1987). The Role of Oxygen Tension in the Regulation of Protein Synthesis in Erythroid Cells. In: Rich, I.N. (eds) Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis. NATO ASI Series, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72652-1_7
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DOI: https://doi.org/10.1007/978-3-642-72652-1_7
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