The Molecular Biology of Erythropoietin

  • Fu-Kuen Lin
Part of the NATO ASI Series book series (volume 8)


The human erythropoietin (Epo) consists of 166 amino acids with a calculated Mr of 18,490. The monkey gene exhibits 92% and 94% homology to the human gene at the amino acid and nucleotide levels, respectively. Studies with Epo analogs reveal that amino acid −2 in human Epo may determine the specificity of the site of signal peptide processing. The Cys29-Cys33 disulphide bridge is essential for Epo function. Mouse erythroblasts contain approximately 43 Epo receptors per cell with a Kd of 90 pM. The receptor molecule consists of 2 chains, 129 Kd and 66 Kd. The Epo gene has been localized to the human chromosome 7q11–q22 region. Restriction fragment length polymorphisms in the Epo gene locus by HindIII and HinfI are observed and they are inherited in a Mendelian manner. The Epo gene linkage map is presented.


Monkey Gene Erythroid Precursor Cell Mendelian Manner Monkey Sequence Cystic Fibrosis Locus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Fu-Kuen Lin
    • 1
  1. 1.AmgenThousand OaksUSA

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