The Cellular Basis of Developmental Changes in Haemoglobin Synthesis

  • W. G. Wood
  • S. Howes
  • C. Bunch
Conference paper
Part of the NATO ASI Series book series (volume 8)


Haemoglobin switching could be controlled at the cellular level by a change in cell populations, an inductive environment or a programmed developmental clock. The pattern of switching after transplantation of fetal haemopoietic cells to adult animals is most consistant with the “clock” hypothesis. Preliminary attempts to modify the kinetics of fetal haemopoiesis did not alter the timing of haemoglobin switching but may have been limited by toxicity.


Globin Gene Stem Cell Pool Fetal Liver Cell Haemopoietic Cell Amphibian Metamorphosis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • W. G. Wood
    • 1
  • S. Howes
    • 1
  • C. Bunch
    • 1
  1. 1.M.R.C. Molecular Haematology Unit, Nuffield Department of Clinical MedicineUniversity of Oxford, John Radcliffe HospitalOxfordUK

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