The Cancer Cell

  • N. S. E. Sargent
  • M. M. Burger


Because of the breadth of this topic, we have had to be somewhat selective about what to include in this review: parts of it are simply annotated bibliography while the relatively long section on metastasis reflects both the fact that this is both clinically at least as relevant an area as primary carcinogenesis as well as the fact that research in this area is rapidly expanding. Several topics of general interest are discussed in the section on metastasis, like angiogenesis and treatment. Many of the references quoted are reviews; an additional three are of general interest: Alberts et al. (1983); Anderson (1985) and Cairns (1981).


Human Papilloma Virus Mouse Melanoma Cell Surface Structure Spontaneous Fusion Acute Monocytic Leukaemia 
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  1. Adams JM (1985) Oncogene activation by fusion of chromosomes in leukaemia. Nature 315: 542–543Google Scholar
  2. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD (1983) Molecular biology of the cell. Garland, New YorkGoogle Scholar
  3. Alby L, Auerbach R (1984) Differential adhesion of tumour cells to capillary endothelial cells in vitro. Proc Natl Acad Sci USA 81: 5739–5743PubMedGoogle Scholar
  4. Anderson JR (1985) Muir’s textbook of pathology, 12th edn. Arnold, LondonGoogle Scholar
  5. Auerbach R, Auerbach W (1982) Regional differences in the growth of normal and neoplastic cells. Science 215: 127–134PubMedGoogle Scholar
  6. Bernstein SC, Weinberg RA (1985) Expression of the metastatic phenotype in cells transfected with human metastatic tumour DNA. Proc Natl Acad Sci USA 82: 1726–1730PubMedGoogle Scholar
  7. Beutler B, Cerami A (1986) Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320: 584–588PubMedGoogle Scholar
  8. Bird AP (1986) CpG-rich islands and the function of DNA methylation. Nature 321: 209–213PubMedGoogle Scholar
  9. Bishop JM (1986) Oncogenes as hormone receptors. Nature 321: 112–113PubMedGoogle Scholar
  10. Brackenbury R (1985) Molecular mechanisms of cell adhesion in normal and transformed cells. Cancer Metastasis Rev 4: 41–58PubMedGoogle Scholar
  11. Cairns J (1981) The origin of human cancers. Nature 289: 353–357PubMedGoogle Scholar
  12. Cheingsong-Popov R, Robinson P, Altevogt P, Schirrmacher V (1983) A mouse hepatocyte carbohydrate-specific receptor and its interaction with liver-metastasizing tumour cells. Int J Cancer 32: 359–366PubMedGoogle Scholar
  13. Cooper GM, Lane MA (1984) Cellular transforming genes and oncogenes. Biochim Biophys Acta 738: 9–20PubMedGoogle Scholar
  14. Craig RW, Sager R (1985) Suppression of tumourgenicity in hybrids of normal and oncogene transformed CHEF cells. Proc Natl Acad Sci USA 82: 2062–3063PubMedGoogle Scholar
  15. Croce CM (1980) Cancer genes in cell hybrids. Biochim Biophys Acta 605: 411–430PubMedGoogle Scholar
  16. Croce CM, Klein G (1985) Chromosome translocations and human cancer. Sci Am 252: 44–50Google Scholar
  17. De Baetselier P, Gorelik E, Eshhar Z, Ron Y, Katzav S, Feldman M, Segal S (1981) Metastatic properties conferred on non-metastatic tumours by hybridization of spleen B-lymphocytes with plasmacytoma cells. JNCI 67: 1079–1087PubMedGoogle Scholar
  18. De Baetselier P, Roos E, Brys L, Remels L, Feldman M (1984 a) Generation of invasive and metastatic variants of a non-metastatic T-cell-lymphoma by in vivo fusion with normal host cells. Int J Cancer 34: 731–738PubMedGoogle Scholar
  19. De Baetselier P, Roos E, Brys L, Remels L, Gobert M, de Kegel D, Segal S, Feldman M (1984 b) Non-metastatic tumour cells acquire metastatic properties following somatic hybridization with normal cells. Cancer Metastasis Rev 3: 5–24PubMedGoogle Scholar
  20. Dennis JW (1985) Partial reversion of the metastatic phenotype in a wheat germ agglutinin-resistant mutant of the murine tumour cell line MDAY-D2 selected with Bandeiraea simplicifolia seed lectin. JNCI 74: 1111–1120PubMedGoogle Scholar
  21. Diaz MO, Le Beau MM, Pitha P, Rowley JD (1986) Interferon and c-ets-1 genes in the translocation (9;11) (p22; q23) in human acute monocytic leukaemia. Science 231: 265–267PubMedGoogle Scholar
  22. Evans EP, Burtenshaw MD, Brown BB, Hennion R, Harris H (1982) The analysis of malignancy by cell fusion. IX. Reexamination and clarification of the cytogenetic problem. J Cell Sci 56: 113–120PubMedGoogle Scholar
  23. Folkman J (1986) How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A.Clowes memorial award lecture. Cancer Res 46: 467–473PubMedGoogle Scholar
  24. Gallatin M, St John TP, Siegelaman M, Reichert R, Butcher EC, Weissman IL (1986) Lymphocyte homing receptors. Cell 44: 673–680PubMedGoogle Scholar
  25. Gerschenson M, Graves K, Carson SD, Wells RS, Pierce GB (1986) Regulation of melanoma by the embryonic skin. Proc Natl Acad Sci USA 83: 7307–7310PubMedGoogle Scholar
  26. Gorelik E, Segal S, Shapiro J, Katzav S, Ron Y, Feldman M (1982) Interactions between the local tumour and its metastasis. Cancer Metastasis Rev 1: 83–94PubMedGoogle Scholar
  27. Goustin AS, Loef EB, Shipley GD, Moses HL (1986) Growth factors and cancer. Cancer Res 46: 1015–1029PubMedGoogle Scholar
  28. Greig RG, Koestler TP, Trainer DL, Corwin SP, Miles L, Kline T, Sweet R, et al. (1985) Tumourigenic and metastatic properties of “normal” and ras-transfected NIH/3T3 cells. Proc Natl Acad Sci USA 82: 3698–3701PubMedGoogle Scholar
  29. Gros P, Neriah YP, Croop JM, Houseman DE (1986) Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323: 728–731PubMedGoogle Scholar
  30. Hansen HZ (1986) Evidence for association between human papilloma virus and neoplasia. Intern Med 7: 66–79Google Scholar
  31. Harris H (1979) Some thoughts about genetics, differentiation and malignancy. Somatic Cell Genet 5: 923–930PubMedGoogle Scholar
  32. Harris H (1985) Suppression of malignancy in hybrid cells: the mechanism. J Cell Sci 79: 83–94PubMedGoogle Scholar
  33. Hart IR (1982) Seed and soil revisited: mechanisms of site-specific metastasis. Cancer Res Rev 1: 5–17Google Scholar
  34. Heppner GH, Miller BE, Miller FR (1983) Tumour subpopulation interactions in neoplasms. Biochim Biophys Acta 695: 215–226PubMedGoogle Scholar
  35. Hujanen ES, Terranova VP (1985) Migration of tumour cells to organ-derived chemoattractants. Cancer Res 45: 3517–3521PubMedGoogle Scholar
  36. Humphries MJ, Matsumoto K, White SL, Olden K (1986 a) Oligosaccharide modification by swainsonine treatment inhibits pulmonary colonization by B16-F10 murine melanoma cells. Proc Natl Acad Sci USA 83: 1752–1756PubMedGoogle Scholar
  37. Humphries MJ, Olden K, Yamada KM (1986 b) A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science 233: 467–470PubMedGoogle Scholar
  38. Hunter T (1984) Oncogenes and protooncogenes: How do they differ? JNCI 73: 773–786PubMedGoogle Scholar
  39. Jones PA (1985) Altering gene expression with 5-azacytidine. Cell 40: 485–486PubMedGoogle Scholar
  40. Kartner N, Evernden-Porelle D, Bradley G, Ling V (1985) Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316: 820–823PubMedGoogle Scholar
  41. Kerbel RS (1982) Tumour heterogeneity, invasion and metastasis. Invasion Metastasis 2: 61–75PubMedGoogle Scholar
  42. Kerbel RS, Lagarde AE, Dennis JW, Donaghue TP (1983) Spontaneous fusion in vivo between normal host and tumour cells: possible contribution to tumour progression and metastasis studied with a lectin resistant mutant tumour. Mol Cell Biol 3: 523–538PubMedGoogle Scholar
  43. Kieran MW, Longenecker BM (1983) Organ-specific metastasis with special reference to avian systems. Cancer Metastasis Rev 2: 165–183PubMedGoogle Scholar
  44. Klein G, Klein E (1985) Evolution of tumours and the impact of molecular oncology. Nature 315:190–195PubMedGoogle Scholar
  45. Kovacs G (1985) Premature chromosome condensation: evidence for in vivo cell fusion in human malignant tumours. Int J Cancer 36: 637–641PubMedGoogle Scholar
  46. Lagarde AE, Kerbel RS (1985) Somatic cell hybridization in vivo and in vitro in relation to the metastatic phenotype. Biochim Biophys Acta 823: 81–110PubMedGoogle Scholar
  47. Land H, Parada LF, Weinberg RA (1983) Cellular oncogenes and multistep carcinogenesis. Science 222: 771–778PubMedGoogle Scholar
  48. Larizza L, Schirrmacher V (1984) Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants. Cancer Metastasis Rev 3: 193–222PubMedGoogle Scholar
  49. Larizza L, Schirrmacher V, Graf L, Pflüger E, Peres-Martinez M, Stohr M (1984 a) Suggestive evidence that the highly metastatic variant ESb of the T-cell lymphoma Eb is derived from spontaneous fusion with a host macrophage. Int J Cancer 34: 699–708PubMedGoogle Scholar
  50. Larizza L, Schirrmacher V, Pflüger E (1984 b) Acquisition of high metastatic capacity after in vitro fusion of a nonmetal-static tumour line with a bone marrow-derived macrophage. J Exp Med 160: 1579–1584PubMedGoogle Scholar
  51. Larizza L, Schirrmacher V, Stöhr M, Pflüger E, Dzarlieva R (1984 c) Inheritance of immunogenicity and metastatic potential in murine cell hybrids from the T-lymphoma ESb08 and normal spleen lymphocytes. JNCI 72: 1371–1381PubMedGoogle Scholar
  52. Lerman MI, Glenn A, Hegameyer B, Colburn NH (1986) Cloning and characterization of putative genes that specify sensitivity to neoplastic transformation by tumour promotors. Int J Cancer 37: 293–302PubMedGoogle Scholar
  53. Ling V, Gerlach J, Kartner N (1984) Multidrug resistance. Breast Cancer Res Treat 4: 89–94PubMedGoogle Scholar
  54. Ling V, Chambers AF, Harris JF, Hill RP (1985) Quantitative genetic analysis of tumour progression. Cancer Metastasis Rev 4: 173–194PubMedGoogle Scholar
  55. Liotta LA (1986) Tumour invasion and metastasis - role of the extra cellular matrix: Rhoads memorial award lecture. Cancer Res 46: 1–7PubMedGoogle Scholar
  56. McConnell I (1983) Roving lymphocytes. Nature 304: 17PubMedGoogle Scholar
  57. Mercurio AM (1986) Disruption of oligosaccharide processing in murine tumour cells inhibits their susceptibility to lysis by activated mouse macrophages. Proc Natl Acad Sci USA 83: 2609–2613PubMedGoogle Scholar
  58. Müller R (1986) Protooncogenes and differentiation. Trends Biochem Sci 11: 129–132Google Scholar
  59. Netland PA, Zetter BR (1984) Organ-specific adhesion of metastatic tumour cells in vitro. Science 224: 1113–1115PubMedGoogle Scholar
  60. Nicolson GL, Custead SE (1982) Tumour metastasis is not due to adaptation of cells to a new organ environment. Science 215: 176–178PubMedGoogle Scholar
  61. Nowell PC (1976) The clonal evolution of tumour cell populations. Acquired genetic lability permits stepwise selection of variant sublines and underlies tumour progression. Science 194: 23–28PubMedGoogle Scholar
  62. Olsson L, Forchhammer J (1984) Induction of the metastatic phenotype in a mouse tumour model by 5-azacytidine, and characterization of an antigen associated with metastatic activity. Proc Natl Acad Sci USA 81: 3389–3393PubMedGoogle Scholar
  63. Ormerod EJ, Everett CA, Hart IR (1986) Enhanced experimental metastatic capacity of a human tumour line following treatment with 5-azacytidine. Cancer Res 46: 884–890PubMedGoogle Scholar
  64. Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 1: 571–573Google Scholar
  65. Poste G, Fidler IJ (1980) The pathogenesis of cancer metastasis. Nature 283: 139–146PubMedGoogle Scholar
  66. Poste G, Greig R (1982) On the genesis of cellular heterogeneity in malignant tumours. Invasion Metastasis 2:137–176PubMedGoogle Scholar
  67. Poste G, Nicolson GL (1980) Arrest and metastasis of blood-borne tumour cells are modified by fusion of plasma membrane vesicles from highly metastatic cells. Proc Natl Acad Sci USA 77: 399–403PubMedGoogle Scholar
  68. Poste G, Doll J, Fidler IJ (1981) Interactions between clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proc Natl Acad Sci USA 78: 6226–6230PubMedGoogle Scholar
  69. Pozzatti R, Muschel R, Williams J, Padmanabhan R, Howard B, Liotta L, Khoury G (1986) Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials. Science 232: 223–227PubMedGoogle Scholar
  70. Ramshaw IA, Carlson S, Wang HC, Badenoch-Jones P (1983) The use of cell fusion to analyse factors involved in tumour cell metastasis. Int J Cancer 32: 471–478PubMedGoogle Scholar
  71. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, Ling V (1985) Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316: 817–819PubMedGoogle Scholar
  72. Roos E, La Rivière G, Collard JG, Stukart MJ, de Baetselier P (1985) Invasiveness of T-cell hybridomas in vitro and their metastatic potential in vivo. Cancer Res 45: 6238–6243PubMedGoogle Scholar
  73. Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE, Matroy YL, et al. (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313: 1485–1492PubMedGoogle Scholar
  74. Rowley JD (1973) A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243: 290–293PubMedGoogle Scholar
  75. Rozengurt E (1986) Early signals in the mitogenic response. Science 234: 161–166PubMedGoogle Scholar
  76. Rubin H (1984) Early origin and pervasiveness of cellular heterogeneity in some malignant transformations. Proc Natl Acad Sci USA 81: 5121–5125PubMedGoogle Scholar
  77. Ruff HR, Pert CB (1984) Small cell carcinoma of the lung: macrophage-specific antigens suggest haemopoetic stem cell origin. Science 225: 1034–1036PubMedGoogle Scholar
  78. Sabin AG (1981) Suppression of malignancy in human cancer cells: Issues and challenges. Proc Natl Acad Sci USA 78: 7129–7133PubMedGoogle Scholar
  79. Sager R (1985) Genetic suppression of tumour formation. Adv Cancer Res 44: 43–68PubMedGoogle Scholar
  80. Sargent NSE, Oestreicher M, Haidvogl H, Madnick HM, Burger MM (1988) Growth regulation of cancer metastases by their host organ. Proc Natl Acad Sci USA 85: 7251–7255PubMedGoogle Scholar
  81. Schaefer R, Iyer J, Iten E, Ninkko AC (1988) Partial reversion of the transformed phenotype in HRAS-transfected tumourigenic cells by transfer of a human gene. Proc Natl Acad Sci USA 85: 1590–1594PubMedGoogle Scholar
  82. Schimke RT (ed) (1982) Gene amplification. Cold Spring Harbour Laboratory, New YorkGoogle Scholar
  83. Schirrmacher V (1985) Cancer metastasis: experimental approaches, theoretical concepts, and impacts for treatment strategies. Adv Cancer Res 43: 1–73PubMedGoogle Scholar
  84. Sloane BF, Roshin J, Johnson K, Taylor H, Crissman JD, Honn KV (1986) Cathepsin B: Association with plasma membrane in metastatic tumours. Proc Natl Acad Sci USA 83: 2483–2487PubMedGoogle Scholar
  85. Sporn MB, Roberts AB (1985) Autocrine growth factors and cancer. Nature 313: 745–747PubMedGoogle Scholar
  86. Springer GF, Cheingsong-Popov R, Schirrmacher V, Desai PR, Tegtmeyer H (1983) Proposed molecular basis of tumour cell-hepatocyte interaction. J Biol Chem 258: 5702–5706PubMedGoogle Scholar
  87. Stanbridge EJ, Wilkinson J (1980) Dissociation of anchorage independence from tumourigenicity in human cell hybrids. Int J Cancer 26: 1–8PubMedGoogle Scholar
  88. Stanbridge EJ, Der CJ, Doersen C-J, Nishimi RY, Peehl DM, Weissman BE, Wilkinson JE (1982) Human cell hybrids: Analysis of transformation and tumourigenicity. Science 215: 252–259PubMedGoogle Scholar
  89. Szaniawska B, Majewski S, Kaminski MJ, Noremberg K, Swierz M, Janik P (1985) Stimulatory and inhibitory activities of lung-conditioned medium on the growth of normal and neoplastic cells in vitro. JNCI 75: 303–306PubMedGoogle Scholar
  90. Talmadge JE, Lenz BF, Klabansky R, Simon R, Riggs C, Guo S, Oldham RK, Fidler IJ (1986) Therapy of autochthonous skin cancers in mice with intravenously injected liposomes containing muramyltripeptide. Cancer Res 46: 1160–1163PubMedGoogle Scholar
  91. Taniguchi K, Karre K, Klein G (1985) Lung colonization and metastasis by disseminated B16 melanoma cells: H-2 associated control at the level of the host and the tumour cell. Int J Cancer 36: 503–510PubMedGoogle Scholar
  92. Tao T-W, Matter A, Vogel K, Burger MM (1979) Liver-colonizing melanoma cells selected from B16 melanoma. Int J Cancer 23: 854–857PubMedGoogle Scholar
  93. Tao T-W, Jenkins JM, Vosbeck K, Matter A, Miller M, Jockusch BM, Shen Z-H, Burger MM (1983) Lectin-resistant variants of mouse melanoma cells. II. In vitro characteristics. Int J Cancer 31: 239–247PubMedGoogle Scholar
  94. Tarin D (1985) Clinical and experimental studies on the biology of metastasis. Biochim Biophys Acta 780: 227–235PubMedGoogle Scholar
  95. Tarin D, Price JE, Kettlewall MGW, Souter RG, Vass ACR, Crossley B (1984 a) Clinicopathological observations on metastasis in man studied in patients treated with peritoneovenous shunts. Br Med J 288: 749–751Google Scholar
  96. Tarin D, Price JE, Kettlewell MGW, Souter RG, Vass ACR, Crossley B (1984 b) Mechanisms of human tumour metastasis studied in patients with peritoneovenous shunts. Cancer Res 44: 3584–3592PubMedGoogle Scholar
  97. Tarin D, Vass ACR, Kettlewell MGW, Price JE (1984 c) Absence of metastatic sequelae during long-term treatment of malignant ascites by peritoneovenous shunting. Invasion Metastasis 4: 1–12PubMedGoogle Scholar
  98. Terranova VP, Hujanen ES, Loeb DM, Martin GR, Thornburg L, Glushko V (1986) Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumour cells. Proc Natl Acad Sci USA 83: 465–469PubMedGoogle Scholar
  99. Thorgeirsson VP, Turpeenniemi-Hujanen T, Williams JE, Westin EH, Heilman CA, Talmadge JE, Liotta LA (1985) NIH/ 3T3 cells transfected with human tumour DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Mol Cell Biol 5: 259–262PubMedGoogle Scholar
  100. Trainer DL, Kline T, Mallon F, Greig R, Poste G (1985) Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells. Cancer Res 45: 6124–6130PubMedGoogle Scholar
  101. Tullberg KF, Burger MM (1985) Selection of B16 melanoma cells with increased metastatic potential and low intercellular cohesion using nucleopore filters. Invasion Metastasis 5: 1–15PubMedGoogle Scholar
  102. Vollmers HP, Imhof BA, Braun S, Waller CA, Schirrmacher V, Birchmeier W (1984) Monoclonal antibodies which prevent experimental lung metastases. Interference with the adhesion of tumour cells to laminin. FEBS Lett 172: 17–20PubMedGoogle Scholar
  103. Waldmann TA (1986) The structure, function and expression of interleukin–2 receptors on normal and malignant lymphocytes. Science 232: 727–732PubMedGoogle Scholar
  104. Wallich R, Bulbuc N, Hammerling GJ, Katzav S, Segal S, Feldman M (1985) Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection. Nature 315: 301–305PubMedGoogle Scholar
  105. Warner JF, Dennert G (1982) Effects of a cloned cell line with NK activity on bone marrow transplants, tumour development and metastasis in vivo. Nature 300: 31–34PubMedGoogle Scholar
  106. Weiss L, Dimitrov DS, Angelova B (1985) The haemodynamic destruction of intravascular cancer cells in relation to myocardial metastasis. Proc Natl Acad Sci USA 82: 5737–5741PubMedGoogle Scholar
  107. Weissman BE, Saxon PJ, Pasquale SR, Jones GR, Geiser AG, Stanbridge EJ (1987) Introduction of a normal human chromosome 11 into a Wilms’ tumour cell line controls its tumourigenic expression. Science 236: 175–180PubMedGoogle Scholar
  108. Yokota J, Tsunetsugu-Yokota Y, Battifora H, LeFevre C, Cline MJ (1986) Alterations of myc, myb and rasHa protooncogenes in cancers are frequent and show clinical correlation. Science 231: 261–265PubMedGoogle Scholar
  109. Zarbl H, Sukumar S, Arthur AV, Martin-Zanca D, Barbacid M (1985) Direct mutagenesis of Haras1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315: 382–385PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • N. S. E. Sargent
  • M. M. Burger

There are no affiliations available

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