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Monoclonal Antibodies as Targeting Agents for Cytotoxic Compounds In Vivo: A Current Assessment

  • J. T. Kemshead
  • D. H. Jones
  • L. Lashford
  • J. Pritchard
  • I. Gordon
  • F. Breatnach
  • H. B. Coakham
Conference paper
Part of the Progress in Pediatric Surgery book series (PEDIATRIC, volume 22)

Abstract

The idea of antibodies acting as magic bullets to target cytotoxic compounds selectively to specific sites in the body was introduced by Hericourt and Richet in 1895 [10] and Ehrlich in 1913 [7]. The use of hetero-antisera as a targeting medium has however, in many cases, been fraught with problems. These include difficulties in absorbing reagents to obtain sera of high specificity, and the irreproducibility of batches of antisera prepared in different animals [3, 13]. Despite this, several workers have successfully used radiolabelled polyclonal antisera for scintigraphic studies in patients with a variety of malignancies [2, 8, 16]. In addition, Order and Lenhard have used radiolabelled hetero-antisera to treat hepatocellular carcinoma and Hodgkin’s disease [15, 20]. To avoid the problem of host antibody responses changing the pharmacokinetics of the targeting agent, they used antibodies prepared in a variety of different species.

Keywords

Target Agent Cytotoxic Compound Target Radiation Therapy Irrelevant Antibody Radiolabelled Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. T. Kemshead
    • 1
  • D. H. Jones
    • 1
  • L. Lashford
    • 1
  • J. Pritchard
    • 2
  • I. Gordon
    • 3
  • F. Breatnach
    • 4
  • H. B. Coakham
    • 5
  1. 1.ICRF Oncology LaboratoriesInstitute of Child HealthLondonUK
  2. 2.Department of Haematology and OncologyThe Hospital for Sick ChildrenLondonUK
  3. 3.Department of Radiology and Nuclear MedicineThe Hospital for Sick ChildrenLondonUK
  4. 4.Our Lady’s Hospital for Sick ChildrenCrumlin, DublinIreland
  5. 5.Department of NeurosurgeryFrenchay HospitalBristolUK

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