Effects of Thyroid Hormone Administration and of Thyroidectomy on the Metabolism of Bilirubin in Rats
Disturbances of thyroid function may lead to jaundice in man. Jaundice with increased conjugated bilirubin levels is known to occur in severe thyrotoxicosis complicated by congestive heart failure [1, 2], but also in hyperthyroidism in the absence of thyroid storm [3, 4]. Unconjugated hyperbilirubinemia has also been reported in hyperthyroid patients . The suggestion was that the patients had an underlying defect in their bilirubin metabolism, such as Gilbert’s syndrome, which was aggravated by the complicating thyrotoxicosis.
KeywordsBile Flow Congenital Hypothyroidism Liver Plasma Membrane Unconjugated Bilirubin Thyroid Storm
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