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Retrovirus-Induced Malignant Histiocytosis in Mice: A Model for the Human Disease

  • J. Löhler
  • T. Franz
  • K. Klingler
  • W. Ostertag
  • R. Padua
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

Malignant histiocytosis, also known as his-tiocytic medullary reticulosis or malignant reticulosis, is a hematopoietic neoplastic disorder characterized by proliferation of abnormal histiocytes and of their precursors, with mostly a rapidly fatal course [1, 2]. Clinical findings are fever, jaundice, pancy-topenia, and enlargement of liver, spleen, and lymph nodes. The etiology of the disease is unknown, although viral infections have been suggested as playing a role [3]. The study of its pathogenesis has been hampered by the lack of a suitable animal model. However, we have recently described a novel retrovirus inducing a systemic neoplastic disease in mice which is strikingly reminiscent of malignant histiocytosis in humans [4].

Keywords

Suitable Animal Model Neoplastic Disorder Permanent Cell Line Malignant Histiocytosis Large Relative Increase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Rappaport H (1966) In: Atlas of tumor pathology, sect 3, fasc 8. Armed Forces Institute of Pathology, Washington, pp 49–63Google Scholar
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    Byrne GE Jr, Rappaport H (1973) Gann Monogr Cancer Res 15:145–162Google Scholar
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    Editorial (1983) Lancet 1:455–456Google Scholar
  4. 4.
    Franz T, Löhler J, Fusco A, Pragneil I, Nobis P, Padua R, Ostertag W (1985) Nature 315:149–151PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. Löhler
    • 1
  • T. Franz
    • 1
  • K. Klingler
    • 1
  • W. Ostertag
    • 1
  • R. Padua
    • 2
  1. 1.Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität HamburgGermany
  2. 2.Marie Curie Memorial FoundationResearch InstituteOxtedUK

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