Abstract
Malignant histiocytosis, also known as his-tiocytic medullary reticulosis or malignant reticulosis, is a hematopoietic neoplastic disorder characterized by proliferation of abnormal histiocytes and of their precursors, with mostly a rapidly fatal course [1, 2]. Clinical findings are fever, jaundice, pancy-topenia, and enlargement of liver, spleen, and lymph nodes. The etiology of the disease is unknown, although viral infections have been suggested as playing a role [3]. The study of its pathogenesis has been hampered by the lack of a suitable animal model. However, we have recently described a novel retrovirus inducing a systemic neoplastic disease in mice which is strikingly reminiscent of malignant histiocytosis in humans [4].
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© 1987 Springer-Verlag Berlin Heidelberg
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Löhler, J., Franz, T., Klingler, K., Ostertag, W., Padua, R. (1987). Retrovirus-Induced Malignant Histiocytosis in Mice: A Model for the Human Disease. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_96
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DOI: https://doi.org/10.1007/978-3-642-72624-8_96
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