Retrovirus-Induced Malignant Histiocytosis in Mice: A Model for the Human Disease

  • J. Löhler
  • T. Franz
  • K. Klingler
  • W. Ostertag
  • R. Padua
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

Malignant histiocytosis, also known as his-tiocytic medullary reticulosis or malignant reticulosis, is a hematopoietic neoplastic disorder characterized by proliferation of abnormal histiocytes and of their precursors, with mostly a rapidly fatal course [1, 2]. Clinical findings are fever, jaundice, pancy-topenia, and enlargement of liver, spleen, and lymph nodes. The etiology of the disease is unknown, although viral infections have been suggested as playing a role [3]. The study of its pathogenesis has been hampered by the lack of a suitable animal model. However, we have recently described a novel retrovirus inducing a systemic neoplastic disease in mice which is strikingly reminiscent of malignant histiocytosis in humans [4].

Keywords

Leukemia Sarcoma Lysozyme Toluidine Histiocytosis 

References

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    Rappaport H (1966) In: Atlas of tumor pathology, sect 3, fasc 8. Armed Forces Institute of Pathology, Washington, pp 49–63Google Scholar
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    Byrne GE Jr, Rappaport H (1973) Gann Monogr Cancer Res 15:145–162Google Scholar
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    Franz T, Löhler J, Fusco A, Pragneil I, Nobis P, Padua R, Ostertag W (1985) Nature 315:149–151PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. Löhler
    • 1
  • T. Franz
    • 1
  • K. Klingler
    • 1
  • W. Ostertag
    • 1
  • R. Padua
    • 2
  1. 1.Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität HamburgGermany
  2. 2.Marie Curie Memorial FoundationResearch InstituteOxtedUK

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