Neutralization and Receptor Recognition of Human T-Lymphotropic Retroviruses

  • R. A. Weiss
  • P. R. Clapham
  • A. G. Dalgleish
  • J. N. Weber
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

Like other enveloped viruses, the outer membrane antigens of retroviruses present target antigens for neutralizing antibodies, and also play a key role in interacting with cell-surface receptors for initial stages of infection. We have investigated these attributes of the envelopes of human T-lymphotropic retroviruses (Weiss 1985; Wong-Staal and Gallo 1985) and our studies are briefly summarized here.

Keywords

Europe Lymphoma Leukemia Titration Phorbol 

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References

  1. 1.
    Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. Cell 46:63–74PubMedCrossRefGoogle Scholar
  2. 2.
    Clapham PR, Weiss RA, Dalgleish AG, Exley M, Whitby D, Hogg N (1987) Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester. Virology 158:44–51PubMedCrossRefGoogle Scholar
  3. 3.
    Clapham P, Nagy K, Weiss RA (1984) Pseudotypes of human T-cell leukaemia types 1 and 2: neutralization by patients’ sera. Proc Natl Acad Sci USA 81:2886–2889PubMedCrossRefGoogle Scholar
  4. 4.
    Clavel F, Guetard D, Brun-Vezinet F, Chamaret S, Rey M-A, Santos-Ferreira MO, Laurent AG, Dauguet C, Katlama C, Rouzioux C, Klatzmann D, Champalimaud JL, Montagnier L (1986) Isolation of a new human retrovirus for West African patients with AIDS. Science 233:343–346PubMedCrossRefGoogle Scholar
  5. 5.
    Dalgleish AG (1986) The T4 molecule: function and structure. Immunology Today 7:142–144CrossRefGoogle Scholar
  6. 6.
    Dalgleish AG, Beverley PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763–767PubMedCrossRefGoogle Scholar
  7. 7.
    Gartner S, Markovits P, Markovits DM, Kaplan MH, Gallo RC, Popovic M (1986) The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233:215–219PubMedCrossRefGoogle Scholar
  8. 8.
    Hoshino HH, Clapham PR, Weiss RA, Miyoshi I, Yoshida M, Miwa M (1985) Human T-cell leukemia virus type I: pseudotype neutralization of Japanese and American isolates with human and rabbit sera. Int J Cancer 36:671–675PubMedCrossRefGoogle Scholar
  9. 9.
    Kalyanaraman VS, Sarngadharan MG, Robert-Guroff M, Miyoshi I, Blayney D, Golde D, Gallo RA (1982) A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218:571PubMedCrossRefGoogle Scholar
  10. 10.
    Klatzman D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercent T, Gluckman J-C, Montagnier L (1984) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312:767–768CrossRefGoogle Scholar
  11. 11.
    Lasky LA, Groopman JE, Fennie CW, Benz PM, Capon DJ, Dowbenko DJ, Nakamura GR, Nunes WM, Renz ME, Berman PW (1986) Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein. Science 233:209–212PubMedCrossRefGoogle Scholar
  12. 12.
    Levy JA, Shimabukuro J, McHugh T, Casavant C, Stites D, Oshino L (1985) AIDS-associated retroviruses (ARV) can productively infect other cells besides human T helper cells. Virology 147:441–448PubMedCrossRefGoogle Scholar
  13. 13.
    Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333–348PubMedCrossRefGoogle Scholar
  14. 14.
    McDougal JS, Kennedy MS, Sligh JM, Cort SP, Mawle A, Nicholson JKA (1986) Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule. Science 231:382–385PubMedCrossRefGoogle Scholar
  15. 15.
    Sattentau QJ, Dalgleish AG, Weiss RA, Beverley PCR (1986) Epitopes of the CD4 antigen and HIV infection. Science 234:1120–1123PubMedCrossRefGoogle Scholar
  16. 16.
    Starcich BR, Hahn BH, Shaw GH, McNeely PD, Modrow S, Wolf H, Parks ES, Parks WP, Josephs SF, Gallo RC, Wong-Staal F (1986) Identification and characterisation of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS. Cell 45:637–648PubMedCrossRefGoogle Scholar
  17. 17.
    Tedder RS, Shanson D, Jeffries D, Cheingsong-Popov R, Clapham P, Dalgleish A, Nagy K, Weiss RA (1984) Low prevalence in the UK of HTLV-1 and HTLV-II infection in subjects with AIDS, with extended lymphadenopathy, and at risk of AIDS. Lancet 11:125–128CrossRefGoogle Scholar
  18. 18.
    Weber JN, Clapham PR, Weiss RA, Parker D, Roberts C, Duncan J, Weiler I, Carne C, Tedder RS, Pinching AJ, Cheingsong-Popov R (1987) Human immunodeficiency virus infection in two cohorts of homosexual men: Neutralising sera and association of anti-gag antibody with prognosis. Lancet I:119–122CrossRefGoogle Scholar
  19. 19.
    Weiss RA (1985) Human T-cell viruses. In: Weiss RA, Teich NM, Varmus HE, Coffin J (eds) RNA tumor viruses, vol 2. Cold Spring Harbor Laboratory, New York, pp 404–485Google Scholar
  20. 20.
    Weiss RA, Clapham PR, Weber JN, Dalgleish AG, Berman PW, Lasky LA (1986) Variable and conserved neutralization antigens of human immunodeficiency virus (HIV-1). Nature 324:572–575PubMedCrossRefGoogle Scholar
  21. 21.
    Weiss RA, Clapham PR, Cheingsong-Popov R, Dalgleish AG, Carne CA, Weller IVD, Tedder RS (1985a) Neutralization of human T-lymphotropic virus type III sera of AIDS and AIDS-risk patients. Nature 316:69–71CrossRefGoogle Scholar
  22. 22.
    Weiss RA, Clapham PR, Nagy K, Hoshino H (1985b) Envelope properties of human T-cell leukemia viruses. Current topics in microbiol. Immunol 115:235–246Google Scholar
  23. 23.
    Wong-Staal F, Gallo RA (1985) Human T-lymphotropic retroviruses. Nature 317:395–403PubMedCrossRefGoogle Scholar
  24. 24.
    Zavada J (1972) Pseudotypes of vesicular somatitis virus with the coat of murine leukemia and of avian myeloblastosis viruses. J Gen Virol 15:183–191PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • R. A. Weiss
    • 1
  • P. R. Clapham
    • 1
  • A. G. Dalgleish
    • 1
  • J. N. Weber
    • 1
  1. 1.Chester Beatty LaboratoriesInstitute of Cancer ResearchLondonEngland

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