Organ-Associated Macrophage Precursor Cells as Effector Cells Against Tumor Targets and Microorganisms

  • M.-L. Lohmann-Matthes
  • T. Decker
  • M. Baccarini
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)


In the past 10 years much attention has been paid to the phenomenon of natural resistance as a first line of defense against tumors and microorganisms. Such natural resistance can be attributed to a certain degree to resting and activated macrophages [1, 2]. The most widely discussed natural effector cell has, however, been the so-called natural killer (NK) cell. Based on their morphological features, NK cells could be classified either as medium-sized lymphocytes [3] or as immature macrophage precursor cells. These two cell types are, in fact, morphologically indistinguishable. We previously presented evidence [4–9] that the NK compartment consists, at least in part, of cells in the early differentiation stages of macrophages. Nonadherent and nonphagocytic macrophage precursor cells can be obtained from in vitro liquid cultures of mouse bone marrow.


Natural Killer Natural Killer Cell Natural Killer Activity Positive Fraction Macrophage Lineage 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M.-L. Lohmann-Matthes
    • 1
  • T. Decker
    • 1
  • M. Baccarini
    • 1
  1. 1.Department of ImmunobiologyFraunhofer Institute of Toxicology and Aerosol ResearchHannover 61Germany

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