Abstract
T-lymphocyte proliferation is regulated by the T-cell growth factor interleukin 2 (IL-2) which exerts its biological effects through an interaction with high-affinity specific IL-2 receptors [1–3]. Quiescent T-lymphocytes neither produce IL-2 nor express IL-2 receptors [2, 4]. However, following immune stimulation there is transcriptional activation of both the IL-2 and IL-2 receptor genes which results in IL-2 synthesis and IL-2 receptor expression [5–7]. T-cell proliferation can then proceed via an autocrine pathway in which the population secretes and responds to its own growth factor.
Keywords
- Phorbol Ester
- Calcium Ionophore
- Inositol Triphosphate
- Cell Antigen Receptor Complex
- Autocrine Proliferation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Smith KA (1980) Immun Rev 41:337
Robb R, Munck A, Smith KA (1981) J Exp Med 154:1455
Cantrell DA, Smith KA (1984) Science 224:1313
Cantrell DA, Smith KA (1983) J Exp Med 158:1895
Efrat S, Pilo S, Kaempfer R (1982) Nature 297:236
Leonard WJ, Kronke M, Peffer NJ, Depper JM, Greene WC (1985) Proc Natl Acad Sci USA 82:6281
Grabstein K, Dower S, Gillis S, Urdal D, Larsen AJ (1986) Immunol 136:4503
Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Schlossman SF, Reinherz EL (1983) J Exp Med 157:707
Acuto O, Hussey RE, Fitzgerald KA, Protentis S, Meuer SC, Schlossman SF, Reinherz EL (1983) Cell 34:717
Meuer SC, Cooper DA, Hodgdon JC, Hussey RE, Fitzgerald KA, Schlossman SF, Reinherz EL (1983) Science 222:1239
Meuer SC, Acuto O, Hussey RE, Hodgdon JC, Fitzgerald KA, Schlossman SF, Reinherz EL (1983) Nature 303:808
Brenner MB, Trowbridge JS, Strominger JL (1985) Cell 40:183
Kannelopoulus JM, Wigglesworth NM, Owen MJ, Crumpton MJ (1983) Embo J 2:1807
Borst J, Alexander S, Elder J, Terhorst C (1983) J Biol Chem 258:5135
Oettgen HC, Terhorst C, Cantley LC, Roscoff PM (1985) Cell 40:583
Roscoff PM, Cantley LW (1983) J Biol Chem 260:14053
Imboden JB, Stobo JO (1985) J Exp Med 161:446
Berridge MJ (1984) Biochem J 220:345
Truneh A, Albert F, Golstein P, Schmitt Verhulot (1985) Nature 313:318
Van Wauve JP, De Mey JR, Goosens JG (1980) J Immunol 124:2708
Burns GF, Boyd AW, Beverley PCL (1982) J Immunol 129:1451
Reinherz EL, Meuer SC, Fitzgerald KA, Hussey RE, Levine H, Schlossman S (1982) Cell 30:735
Weiss A, Wiskocil RL, Stobo JD (1984) J Immunol 133:123
Ando I, Hariri G, Wallace D, Beverley P (1983) Euro J Immunol 15:196
Delia D, Greaves MF, Newman M, Sutherland DR, Minowada J, Kung P, Goldstein G (1982) Int J Cancer 29:23
Cantrell DA, Davies AA, Crumpton MJ (1985) Proc Natl Acad Sci USA 82:8158
Davies AA, Cantrell DA, Crumpton MJ (1985) Biosciences 5:867
Sibley DR, Strasser RH, Caron MG, Lefkowitz RJ (1985) J Biol Chem 260:3883
Huganir RL, Delcour AH, Greengard P, Hess G (1986) Nature 321:774
Shoyab M, Daharao JE, Todaro GT (1979) Nature (London) 279:387
Cochet C, Gill GN, Meisenhelder J, Cooper JA, Hunter T (1984) J Biol Chem 259:2553
Iwashita S, Fox CF (1984) J Biol Chem 259:2559
Davis RJ, Czech MP (1985) Proc Natl Acad Sci USA 82:1974
Parker PJ, Coussens L, Totty N, Rhee L, Young S, Chen E, Stabel S, Waterfield MD, Ullrich A (1986) Science 233:853
Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (1986) Science 233:859
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Cantrell, D.A., Davies, A.A., Verbi, W., Crumpton, M.J. (1987). The Regulation of T-Cell Proliferation: A Role for Protein Kinase C. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_71
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DOI: https://doi.org/10.1007/978-3-642-72624-8_71
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