The Regulation of T-Cell Proliferation: A Role for Protein Kinase C

  • D. A. Cantrell
  • A. A. Davies
  • W. Verbi
  • M. J. Crumpton
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)


T-lymphocyte proliferation is regulated by the T-cell growth factor interleukin 2 (IL-2) which exerts its biological effects through an interaction with high-affinity specific IL-2 receptors [1–3]. Quiescent T-lymphocytes neither produce IL-2 nor express IL-2 receptors [2, 4]. However, following immune stimulation there is transcriptional activation of both the IL-2 and IL-2 receptor genes which results in IL-2 synthesis and IL-2 receptor expression [5–7]. T-cell proliferation can then proceed via an autocrine pathway in which the population secretes and responds to its own growth factor.


Phorbol Ester Calcium Ionophore Inositol Triphosphate Cell Antigen Receptor Complex Autocrine Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • D. A. Cantrell
    • 1
  • A. A. Davies
    • 1
  • W. Verbi
    • 1
  • M. J. Crumpton
    • 1
  1. 1.Cell Surface BiochemistryImperial Cancer Research LaboratoriesLondonUK

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