Cancer Clonality and Field Theory
A field theory  models malignancy as a state “added” to, and capable of interacting with, other normal states composing the field associated with any living cell. The theory may be downscaled from the (multi) cellular to the level of topologically disordered motions of chromatin and DNA strings occurring before or at interphase when chromatids are iteratively dilated in cells mitotically driven by a potential from special “source” cells. Clonal development of tumors might result from the extremely low efficiency with which the driving potential activates its corresponding gene(s) P in one (or exceedingly few) source-dependent cell. Most normal cells are assumed to have gene P “curled up” in some nonexpressed configuration in a segment j (say) within a lattice or plaquette unfolded from crumpled preimages during chromatid decondensation [11–13].
KeywordsClonal Development Peano Curve Negative Gaussian Curvature Menger Sponge String Segment
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