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Cancer Clonality and Field Theory

  • G. T. Matioli
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

A field theory [1] models malignancy as a state “added” to, and capable of interacting with, other normal states composing the field associated with any living cell. The theory may be downscaled from the (multi) cellular to the level of topologically disordered motions of chromatin and DNA strings occurring before or at interphase when chromatids are iteratively dilated in cells mitotically driven by a potential from special “source” cells. Clonal development of tumors might result from the extremely low efficiency with which the driving potential activates its corresponding gene(s) P in one (or exceedingly few) source-dependent cell. Most normal cells are assumed to have gene P “curled up” in some nonexpressed configuration in a segment j (say) within a lattice or plaquette unfolded from crumpled preimages during chromatid decondensation [11–13].

Keywords

Clonal Development Peano Curve Negative Gaussian Curvature Menger Sponge String Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • G. T. Matioli
    • 1
  1. 1.USC Medical SchoolLos AngelesUSA

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