Abstract
Major histocompatibility complex (MHC) class I antigens (termed H-2K, D and L in mice) are widely distributed on nearly all cell types and play an indispensable role in immunoregulation: lysis of neoplastic cells by cytotoxic T-lymphocytes depends on the expression of class I antigens. Therefore, it is of interest that certain tumours express decreased amounts of class I antigens. This may allow the tumours to escape immune surveillance in vivo.
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Reference
Hui K, Grosveld F, Festenstein H (1984) Nature 311:750–752
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© 1987 Springer-Verlag Berlin Heidelberg
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Hui, K., Grosveld, F.G. (1987). Modification of Oncogenicity of Tumour Cells by DNA-Mediated Gene Transfer. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_54
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DOI: https://doi.org/10.1007/978-3-642-72624-8_54
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