Modification of Oncogenicity of Tumour Cells by DNA-Mediated Gene Transfer

  • K. Hui
  • F. G. Grosveld
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)


Major histocompatibility complex (MHC) class I antigens (termed H-2K, D and L in mice) are widely distributed on nearly all cell types and play an indispensable role in immunoregulation: lysis of neoplastic cells by cytotoxic T-lymphocytes depends on the expression of class I antigens. Therefore, it is of interest that certain tumours express decreased amounts of class I antigens. This may allow the tumours to escape immune surveillance in vivo.


Major Histocompatibility Complex Major Histocompatibility Complex Class Indispensable Role Express Major Histocompatibility Complex Class Secondary Challenge 
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  1. 1.
    Hui K, Grosveld F, Festenstein H (1984) Nature 311:750–752PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • K. Hui
    • 1
  • F. G. Grosveld
    • 1
  1. 1.Institute of Molecular and Cell BiologyNational University of SingaporeKent RidgeSingapore

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