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Modification of Oncogenicity of Tumour Cells by DNA-Mediated Gene Transfer

  • K. Hui
  • F. G. Grosveld
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

Major histocompatibility complex (MHC) class I antigens (termed H-2K, D and L in mice) are widely distributed on nearly all cell types and play an indispensable role in immunoregulation: lysis of neoplastic cells by cytotoxic T-lymphocytes depends on the expression of class I antigens. Therefore, it is of interest that certain tumours express decreased amounts of class I antigens. This may allow the tumours to escape immune surveillance in vivo.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Indispensable Role Express Major Histocompatibility Complex Class Secondary Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

  1. 1.
    Hui K, Grosveld F, Festenstein H (1984) Nature 311:750–752PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • K. Hui
    • 1
  • F. G. Grosveld
    • 1
  1. 1.Institute of Molecular and Cell BiologyNational University of SingaporeKent RidgeSingapore

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