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The myc Oncogene and Lymphoid Neoplasia: From Translocations to Transgenic Mice

  • S. Cory
  • A. W. Harris
  • W. Y. Langdon
  • W. S. Alexander
  • L. M. Corcoran
  • R. D. Palmiter
  • C. A. Pinkert
  • R. L. Brinster
  • J. M. Adams
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

The c-myc proto-oncogene encodes a nuclear phosphoprotein which probably plays a crucial role in growth control [4]. The protein has DNA-binding activity in vitro, but its function remains unknown. While avian retroviruses carrying the closely related v-myc sequence rapidly transform myeloid cells, the cellular myc gene has been strongly implicated in several types of lymphoid neoplasia. The fundamental mechanism releasing the oncogenic potential of c-myc is believed to be deregulation of its expression. Most chicken bursal lymphomas resulting from infection with avian leukosis virus, which does not itself bear an oncogene, carry a provirus near or within the c-myc gene [6]. About a quarter of T lymphomas with a retroviral aetiology also bear a c-myc-associated provirus [3].

Keywords

Long Terminal Repeat Avian Leukosis Virus Panded Population Lymphoid Neoplasia Cell Surface Marker Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • S. Cory
    • 1
  • A. W. Harris
  • W. Y. Langdon
  • W. S. Alexander
  • L. M. Corcoran
  • R. D. Palmiter
  • C. A. Pinkert
  • R. L. Brinster
  • J. M. Adams
  1. 1.Royal Melbourne HospitalMelbourneAustralia

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