The myc Oncogene and Lymphoid Neoplasia: From Translocations to Transgenic Mice

  • S. Cory
  • A. W. Harris
  • W. Y. Langdon
  • W. S. Alexander
  • L. M. Corcoran
  • R. D. Palmiter
  • C. A. Pinkert
  • R. L. Brinster
  • J. M. Adams
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)


The c-myc proto-oncogene encodes a nuclear phosphoprotein which probably plays a crucial role in growth control [4]. The protein has DNA-binding activity in vitro, but its function remains unknown. While avian retroviruses carrying the closely related v-myc sequence rapidly transform myeloid cells, the cellular myc gene has been strongly implicated in several types of lymphoid neoplasia. The fundamental mechanism releasing the oncogenic potential of c-myc is believed to be deregulation of its expression. Most chicken bursal lymphomas resulting from infection with avian leukosis virus, which does not itself bear an oncogene, carry a provirus near or within the c-myc gene [6]. About a quarter of T lymphomas with a retroviral aetiology also bear a c-myc-associated provirus [3].


Long Terminal Repeat Avian Leukosis Virus Panded Population Lymphoid Neoplasia Cell Surface Marker Analysis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • S. Cory
    • 1
  • A. W. Harris
  • W. Y. Langdon
  • W. S. Alexander
  • L. M. Corcoran
  • R. D. Palmiter
  • C. A. Pinkert
  • R. L. Brinster
  • J. M. Adams
  1. 1.Royal Melbourne HospitalMelbourneAustralia

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