The myc Oncogene and Lymphoid Neoplasia: From Translocations to Transgenic Mice
The c-myc proto-oncogene encodes a nuclear phosphoprotein which probably plays a crucial role in growth control . The protein has DNA-binding activity in vitro, but its function remains unknown. While avian retroviruses carrying the closely related v-myc sequence rapidly transform myeloid cells, the cellular myc gene has been strongly implicated in several types of lymphoid neoplasia. The fundamental mechanism releasing the oncogenic potential of c-myc is believed to be deregulation of its expression. Most chicken bursal lymphomas resulting from infection with avian leukosis virus, which does not itself bear an oncogene, carry a provirus near or within the c-myc gene . About a quarter of T lymphomas with a retroviral aetiology also bear a c-myc-associated provirus .
KeywordsLong Terminal Repeat Avian Leukosis Virus Panded Population Lymphoid Neoplasia Cell Surface Marker Analysis
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