Abstract
For a number of lysosomal hydrolases, abnormally expressed forms have been found to occur in childhood and adult leukemia. Most of these abnormalities are confined to the physicochemical properties of the enzymes, e.g., abnormal electrophoretic mobility, change of isoelectric point, and alteration of isoenzyme pattern. All this has been described for the hexosaminidase system in human leukemia cells. The most-investigated phenomenon is the occurrence of hexosaminidase I [1–3, 5, 6, 19]. Other abnormalities, such as the anodic shift of the Hex A isoenzyme [2, 6] or a relative decrease of the Hex B form [1], are found in various leukemia subtypes.
Supported by the Deutsche Forschungsgemeinschaft (Grants SFB 112, Project B10 and Project Ga 167/4–1).
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Novotny, J.R., Brendler, S., Kytzia, H.J., Sandhoff, K., Gaedicke, G. (1987). Hexosaminidase I Indicates Maturation Disarrangement in Acute Leukemias. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_42
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DOI: https://doi.org/10.1007/978-3-642-72624-8_42
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