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Leukemic Colony-Forming Cells in Acute Myeloblastic Leukemia: Maturation Hierarchy and Growth Conditions

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Modern Trends in Human Leukemia VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 31))

Abstract

Despite their primitive morphological appearance, the majority of leukemic blasts in acute myeloblastic leukemia (AML) are end-stage, nonproliferating cells. Only a small subset of AML blasts are capable of a sufficient number of divisions to form colonies in semisolid medium [1, 2]. It has been suggested that these leukemic colony-forming cells (L-CFC) may act in vivo as progenitor cells to maintain the rest of the leukemic cell population [3, 4]. L-CFC share several properties with normal myeloid progenitor cells, including self-renewal potential and high thymidine suicide index [2, 3]. As in the case of normal myeloid progenitor cells (NMPC), colony growth of L-CFC from most patients requires exogenous colony-stimulating factors (CSF) which are routinely supplied by the addition of media conditioned by activated T cells, placental tissue, or media derived from various tumor cell lines, including GCT [5], MO [6], or 5637 [7].

Supported in part by a grant (He 1380-2/1) from the Deutsche Forschungsgemeinschaft.

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Author information

Authors and Affiliations

  1. Departments of Hematology, Johannes Gutenberg University, Mainz, Germany

    F. Herrmann, W. Oster, A. Lindemann & A. Ganser

  2. Johann Wolfgang Goethe University, Frankfurt, Germany

    F. Herrmann, W. Oster, A. Lindemann & A. Ganser

  3. Ruprecht-Karls University, Heidelberg, Germany

    B. Dörken

  4. Immunological Institute, University of Vienna, Austria

    W. Knapp

  5. Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

    J. D. Griffin & R. Mertelsmann

Authors
  1. F. Herrmann
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  2. W. Oster
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  3. A. Lindemann
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  4. A. Ganser
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  5. B. Dörken
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  6. W. Knapp
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  7. J. D. Griffin
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  8. R. Mertelsmann
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Institute of Cancer Research, Chester Beatty Laboratories, Leukemia Research Fund Centre, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Hartmut Kabisch

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© 1987 Springer-Verlag Berlin Heidelberg

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Herrmann, F. et al. (1987). Leukemic Colony-Forming Cells in Acute Myeloblastic Leukemia: Maturation Hierarchy and Growth Conditions. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_41

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  • DOI: https://doi.org/10.1007/978-3-642-72624-8_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17754-8

  • Online ISBN: 978-3-642-72624-8

  • eBook Packages: Springer Book Archive

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