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The Secretion of Plasminogen Activators by Human Bone Marrow Progenitor Cells

  • Conference paper
Book cover Modern Trends in Human Leukemia VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 31))

  • 38 Accesses

Abstract

Leukaemic cells from patients with acute myeloid leukaemia (AML) and chronic myeloid leukaemia (CML) secrete plasminogen activators either of the urokinase (u-PA) or of the tissue plasminogen activator (t-PA) type. The enzyme has prognostic significance in that those individuals with AML whose cells secreted only t-PA failed to respond to combination chemotherapy, whereas those whose cells released u-PA alone or a combination of u-PA and t-PA could be induced to remission (Wilson et al. 1983).

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References

  1. Collen D, Stassen JM, Verstraete M (1983) Thrombolysis with human extrinsic (tissue-type) plasminogen activator in rabbits with experimental jugular vein thrombosis. J Clin Invest 71:368–376

    Article  PubMed  CAS  Google Scholar 

  2. Fauser AA, Messner HA (1978) Granuloer-thyopoeitic colonies in human bone marrow, peripheral blood and cord blood. Blood 52:1243–1248

    PubMed  CAS  Google Scholar 

  3. Francis GE, Berney JJ, Chipping M, Hoffbrand AV (1979) Stimulation of human haemopoeitic cells by colony stimulating factors; sensitivity of leukemic cells. Br J Haematol 41:545–566

    Article  PubMed  CAS  Google Scholar 

  4. Francis GE, Boll SJL, Berney JJ (1981a) Clone size potential and sensitivity to colony stimulating activity: differentiation linked properties of granulocyte — macrophage progenitor cells. Stem Cells 1:124–139

    CAS  Google Scholar 

  5. Francis GE, Tuma GA, Berney JJ, Hoffbrand AV (1981b) Sensitivity of acute myeloid leukemia cells to colony stimulating activity: relation to response to chemotherapy. Br J Haematol 49:1259–1267

    Article  Google Scholar 

  6. Granelli-Piperno A, Vassali J-D, Reich E (1977) Secretion of plasminogen activator by human polymorphonuclear leucocytes. J Exp Med 146:1693–1706

    Article  PubMed  CAS  Google Scholar 

  7. Loos JA, Roos D (1974) Ficoll-isopaque gradients for the determination of density distribution of human blood lymphocytes and other reticulo-endothelial cells. Exp Cell Res 86:331–341

    Google Scholar 

  8. McCulloch EA, Curtis JE, Messner HA, Senn JS, Germanson TP (1982) The contribution of blast cell properties to outcome variation in AML. Blood 59:601–608

    PubMed  CAS  Google Scholar 

  9. Moore MAS, Spitzer G, Williams M, Metcalf D, Buckley J (1974) Agar culture studies in 127 cases of untreated leukemia: the prognostic value of reclassification of leukemia according to in vitro growth characteristics. Blood 44:1–8

    PubMed  CAS  Google Scholar 

  10. Pike BL, Robinson WA (1970) Human bone marrow colony growths in agar gel. J Cell Physiol 76:77–84

    Article  PubMed  CAS  Google Scholar 

  11. Reich E (1978) Activation of plasminogen: a general mechanism for producing localized extracellular proteolysis. In: Berlin RD, Herman H, Lepow IH, Tanzer JM (eds) Molecular basis of biological degradative processes. Academic, New York, pp 155–169

    Google Scholar 

  12. Tucker WS, Kirsch WM, Martinez-Hernandez A, Fink LM (1978) In vitro plasminogen activator activity in human brain tumours. Cancer Res 38:297–302

    PubMed  CAS  Google Scholar 

  13. Vassali J-D, Hamilton J, Reich E (1977) Macrophage plasminogen activator; induction by concanavalin A and phorbol myristate acetate. Cell 11:695–705

    Article  Google Scholar 

  14. Vetterlein D, Young PL, Bell TE, Roblin R (1979) Immunological characterization of multiple molecular weight forms of human cell plasminogen activators. J Biol Chem 254:575–578

    PubMed  CAS  Google Scholar 

  15. Wilson EL, Kirsch WM, Martinez-Hernandez A, Fink LM (1978) In vitro plasminogen activator activity in human brain tumours. Cancer Res 38:297–302

    Google Scholar 

  16. Wilson EL, Becker MLB, Hoal EG, Dowdle EB (1980) Molecular species of plasminogen activators secreted by normal and neoplastic human cells. Cancer Res 40:933–938

    PubMed  CAS  Google Scholar 

  17. Wilson EL, Jacobs P, Dowdle EB (1983) The secretion of plasminogen activators by human myeloid leukemic cells in vitro. Blood 61:568–574

    PubMed  CAS  Google Scholar 

  18. Wilson EL, Francis GE (1987) Differentiation linked secretion of urokinase and tissue plasminogen activator by normal human haemopoetic cells. J Exp Med 165:1609–1629

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Clinical Science and Immunology, University of Cape Town Medical School, Observatory, Cape Town, South Africa

    E. L. Wilson

  2. Department of Haematology, Royal Free Hospital, Pond Street, Hampstead, London, England

    G. E. Francis

Authors
  1. E. L. Wilson
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  2. G. E. Francis
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Institute of Cancer Research, Chester Beatty Laboratories, Leukemia Research Fund Centre, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Hartmut Kabisch

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© 1987 Springer-Verlag Berlin Heidelberg

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Wilson, E.L., Francis, G.E. (1987). The Secretion of Plasminogen Activators by Human Bone Marrow Progenitor Cells. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_40

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  • DOI: https://doi.org/10.1007/978-3-642-72624-8_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17754-8

  • Online ISBN: 978-3-642-72624-8

  • eBook Packages: Springer Book Archive

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