Hemopoietic Growth Factors and Oncogenes in Myeloid Leukemia Development
Understanding of the abnormal nature of cancer cells has advanced rapidly in the past decade because of work in two apparently separate fields — those of oncogenes and specific growth-regulatory factors. What has intrigued workers in both fields has been the recognition that, in a number of instances, the products of oncogenes or proto-onco-genes have been shown to be related either to growth factors themselves or to the receptors for such growth factors. The reported examples of this association are already numerous enough to make a chance association improbable — c-sis and PDGF , c-erb-B and the EGF receptor , c-fms and the CSF-1 receptor . When this association is considered in the light of the numerous documented examples, particularly in the leukemias and lymphomas, of non-random chromosomal translocations that involve proto-oncogenes , a strong case exists for formalizing earlier notions of cancer into a concept that neoplastic change results from aberrant or aberrantly expressed genes that code for growth factors or growth factor receptors.
KeywordsHydrate Lymphoma Leukemia Anemia Disulfide
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