Hemopoietic Growth Factors and Oncogenes in Myeloid Leukemia Development
Understanding of the abnormal nature of cancer cells has advanced rapidly in the past decade because of work in two apparently separate fields — those of oncogenes and specific growth-regulatory factors. What has intrigued workers in both fields has been the recognition that, in a number of instances, the products of oncogenes or proto-onco-genes have been shown to be related either to growth factors themselves or to the receptors for such growth factors. The reported examples of this association are already numerous enough to make a chance association improbable — c-sis and PDGF , c-erb-B and the EGF receptor , c-fms and the CSF-1 receptor . When this association is considered in the light of the numerous documented examples, particularly in the leukemias and lymphomas, of non-random chromosomal translocations that involve proto-oncogenes , a strong case exists for formalizing earlier notions of cancer into a concept that neoplastic change results from aberrant or aberrantly expressed genes that code for growth factors or growth factor receptors.
KeywordsAcute Myeloid Leukemia Myeloid Leukemia HL60 Cell Myeloid Leukemic Cell Human Myeloid Leukemic Cell
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- 1.Johnson A, Heldin C-H, Wasteson A, Westermark B, Deuel TF, Huang JS, Seeburg PH, Gray A, Ullrich A, Scrace G, Stroobant P, Waterfield MD (1984) The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J 3:921–928Google Scholar
- 2.Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tarn AW, Lee J, Yarden Y, Liebermann TA, Schlessinger J, Downward J, Mayes ELV, Whittle N, Waterfield MD, Seeburg PH (1984) Human epidermal growth factor receptor cDNA sequence and aberrant expression in the amplified gene in A431 epidermal carcinoma cells. Nature 309:418–425PubMedCrossRefGoogle Scholar
- 9.Wong GG, Witek J, Temple PA, Wilkens KM, Leary AC, Luxenberg DF, Jones SS, Brown EC, Kay RM, Orr EC, Shoemaker C, Golde DW, Kaufman RJ, Hewick RM, Wang EA, Clark SC (1985) Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 228:810–815PubMedCrossRefGoogle Scholar
- 12.Kawasaki ES, Ladner MB, Wang AM, Arsdell J Van, Warren MK, Coyne MY, Schweickart VL, Lee M-T, Wilson KJ, Boosman A, Stanley ER, Ralph P, Mark DF (1985) Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). Science 230:291–296PubMedCrossRefGoogle Scholar
- 15.Metcalf D (1984) The hemopoietic colony-stimulating factors. Elsevier, AmsterdamGoogle Scholar
- 33.Olssen I, Sarngadharan MG, Breitman TR, Gallo RC (1984) Isolation and characterization of a T-lymphocyte-derived differentiation-inducing factor for the myeloid leukemic cell line HL-60. Blood 63:510–517Google Scholar
- 40.Metcalf D, Nicola NA (1985) Role of the colony-stimulating factors in the emergence and suppression of myeloid leukemia populations. In: Wahren B et al. (eds) Molecular biology of tumor cells. Raven, New York, pp 215–232Google Scholar