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Hemopoietic Growth Factors and Oncogenes in Myeloid Leukemia Development

  • Conference paper
Modern Trends in Human Leukemia VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 31))

  • 39 Accesses

Abstract

Understanding of the abnormal nature of cancer cells has advanced rapidly in the past decade because of work in two apparently separate fields — those of oncogenes and specific growth-regulatory factors. What has intrigued workers in both fields has been the recognition that, in a number of instances, the products of oncogenes or proto-onco-genes have been shown to be related either to growth factors themselves or to the receptors for such growth factors. The reported examples of this association are already numerous enough to make a chance association improbable — c-sis and PDGF [1], c-erb-B and the EGF receptor [2], c-fms and the CSF-1 receptor [3]. When this association is considered in the light of the numerous documented examples, particularly in the leukemias and lymphomas, of non-random chromosomal translocations that involve proto-oncogenes [4], a strong case exists for formalizing earlier notions of cancer into a concept that neoplastic change results from aberrant or aberrantly expressed genes that code for growth factors or growth factor receptors.

The work from the author’s laboratory was supported by the Carden Fellowship Fund of the Anti-Cancer Council of Victoria, The National Health and Medical Research Council, Canberra and The National Institutes of Health, Bethesda, Grant Nos. CA-22556 and CA-25972.

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Authors and Affiliations

  1. Cancer Research Unit, Walter and Eliza Hall Institute, P.O. Royal Melbourne Hospital, 3050, Victoria, Australia

    D. Metcalf

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  1. D. Metcalf
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Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Institute of Cancer Research, Chester Beatty Laboratories, Leukemia Research Fund Centre, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Hartmut Kabisch

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© 1987 Springer-Verlag Berlin Heidelberg

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Metcalf, D. (1987). Hemopoietic Growth Factors and Oncogenes in Myeloid Leukemia Development. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-72624-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17754-8

  • Online ISBN: 978-3-642-72624-8

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