Sensitivity of Stromal Elements from Human Bone Marrow Cells to Cytosine Arabinoside In Vitro
Cytosine arabinoside (Ara-C) is one of the most effective agents in the treatment of acute myelogenous leukemia (AML). Recently, low-dose Ara-C therapy has been the subject of topical interest in view of its differentiation-inducing effect on leukemic blast cells. Many patients, however, develop severe aplasia with low-dose Ara-C therapy [1, 6, 10, 11]. The aim of our study was to obtain some information about causes of this aplasia, i.e., to determine whether the lesion is primarily in the hemopoietic stem cells or whether there is any additional damage done to stromal elements.
KeywordsAcute Myelogenous Leukemia Cytosine Arabinoside Hemopoietic Stem Cell Stromal Element Stromal Layer
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