Human B-Cell Growth and Differentiation Factors, and Their Effects on Leukemic B-Cells

  • F. C. Rawle
  • R. J. Armitage
  • P. C. L. Beverley
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)


A wealth of data on B-cell growth and differentiation factors has been published recently, and so many different factors have been shown to act on B cells [1] that it is difficult to determine which, if any, of these factors are physiologically relevant. Initial models assumed that B-cell activation leads to an ordered expression of receptors for specific growth and then differentiation factors, but these now appear to be incorrect. Firstly, most of the factors with functional effects on B cells are not specific for cells of that lineage. IL2, IL1 and IFNγ have all been shown to have effects on B cells [1, 2]. Secondly, BSF-2 (B-cell differentiation factor BCDFγ), which has recently been cloned [3], has been shown to activate mast cells and basophils, and to cause T-cell proliferation [4], while BCGF II acts as a differentiation factor for eosinophils [5].


Chronic Lymphocytic Leukaemia Bladder Carcinoma Chronic Lymphocytic Leukaemia Cell Activate Mast Cell Mixed Lymphocyte Reaction 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • F. C. Rawle
    • 1
    • 2
  • R. J. Armitage
    • 1
  • P. C. L. Beverley
    • 1
  1. 1.ICRF Human Tumour Immunology Group, Faculty of Clinical SciencesUniversity College LondonLondonUK
  2. 2.Department of Zoology and Comparative AnatomyUniversity College LondonLondonUK

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