Abstract
Neuroblastoma is one of the most common solid tumors in childhood, with some unusual neoplastic behavior depending on the age of the affected children. Patients older than 1 year who have metastatic disease have a very poor prognosis. However, in children younger than 1 year who have disseminated disease, regression of neuroblastoma often occurs after only minimal therapy, or even spontaneously. This latter feature and other observations led to longstanding speculations that cytotoxic effector cells of the tumor-bearing host may contribute to this biological behavior of human neuroblastoma [1]. Recently, Main et al. [2] published data concerning the interaction of human neuroblastoma cell lines with effector cells. They demonstrated that the neuroblastoma cell lines CHP 100 and CHP 126 were lysed by natural killer (NK) cells but not by cytotoxic T-lymphocytes [2].
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References
Bill AH, Morgan A (1970) Evidence for immune reaction to neuroblastoma and future possibilities for investigation. J Pediatr Surg 5:111
Main EJ, Lampson LA, Hart MK, Kornbluth J, Wilson DB (1985) Human neuroblastoma cell lines are susceptible to lysis by natural killer cells but not by cytotoxic T lymphocytes. J Immunol 135:242
Lampson LA, Fisher CA, Whelan JP (1983) Striking paucity of HLA-A,B,C and β2-micro-globulin on human neuroblastoma cell lines. J Immunol 130:2471
Rosenberg SA (1985) Lymphokine-activated killer cells: a new approach to immunotherapy of cancer. JNCI 75:595
Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55
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© 1987 Springer-Verlag Berlin Heidelberg
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Handgretinger, R., Bruchelt, G., Schneider, M., Niethammer, D., Treuner, J. (1987). Application of Interleukin 2 in Neuroblastoma. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_24
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DOI: https://doi.org/10.1007/978-3-642-72624-8_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17754-8
Online ISBN: 978-3-642-72624-8
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