Abstract
Children with relapsed common acute lymphoblastic leukemia (ALL), B-non-Hodgkin lymphoma (B-NHL), and B-acute lymphocytic leukemia (B-ALL) have a very poor prognosis. If there is no HLA-identical donor, the patient should be considered for autologous bone marrow transplantation. Collected autologous marrow should be cleansed of contaminating tumor cells without destroying hemopoietic stem cells. We report here the results of our investigations with a cocktail of three monoclonal antibodies (VIL-A 1, VIB-C 5, and VIB-E 3 — the VIB pool — kindly given to us by Dr. Knapp of Vienna) concerning in vitro cytotoxicity against ALL blast cells and leukemic cells lines, lytic capacity with rabbit and human complement, and stem cell toxicity, together with our findings concerning the ex vivo purging of the marrow of four children.
Keywords
- Autologous Bone Marrow Transplantation
- Autologous Serum
- Hemopoietic Stem Cell
- Human Complement
- Antibody Cocktail
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This investigation was supported by the Internationale Gesellschaft für Chemo- und Immunotherapie, Vienna
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References
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© 1987 Springer-Verlag Berlin Heidelberg
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Zintl, F., Reiners, B., Thränhardt, H., Hermann, J., Fuchs, D., Prager, J. (1987). Purging of Bone Marrow with a Cocktail of Monoclonal Antibodies (VIB-pool) for Autologous Transplantation. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_19
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DOI: https://doi.org/10.1007/978-3-642-72624-8_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17754-8
Online ISBN: 978-3-642-72624-8
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