Identification of the Bovine Leukemia Virus Transactivating Protein (p34x)
Enzootic bovine leukosis (EBL) has been recognized as a neoplasm of infectious origin for half a century. The agent, bovine leukemia virus (BLV), is a retrovirus discovered in 1969 in short-term cultures of peripheral lymphocytes from animals with persistent lymphocytosis, a benign response to BLV infection. A virus distantly related to BLV was more recently identified as the etiological agent in the vast majority of cases of adult T cell leukemia and named for that reason human T-lymphotropic virus I (HTLV-I) . The pathologies of BLV- and HTLV-I-in-duced diseases are notably similar, namely absence of chronic viremia, a long latency period, and lack of preferred integration sites in tumors. A second human virus, called HTLV-II, was identified in the Mo T cell line, derived in 1976 from the spleen of a patient with T cell-variant hairy cell leukemia [2, 10]. Other isolates of HTLV-I and -II have since been obtained around the world. Both viruses not only transform normal T-lymphocytes but might also very well be involved in a number of degenerative diseases of the nervous system.
KeywordsLong Terminal Repeat Bovine Leukemia Virus P34x Expression Persistent Lymphocytosis Enzootic Bovine Leukosis
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