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Identification of the Bovine Leukemia Virus Transactivating Protein (p34x)

  • L. Willems
  • R. Kettmann
  • D. Portetelle
  • A. Burny
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

Enzootic bovine leukosis (EBL) has been recognized as a neoplasm of infectious origin for half a century. The agent, bovine leukemia virus (BLV), is a retrovirus discovered in 1969 in short-term cultures of peripheral lymphocytes from animals with persistent lymphocytosis, a benign response to BLV infection. A virus distantly related to BLV was more recently identified as the etiological agent in the vast majority of cases of adult T cell leukemia and named for that reason human T-lymphotropic virus I (HTLV-I) [20]. The pathologies of BLV- and HTLV-I-in-duced diseases are notably similar, namely absence of chronic viremia, a long latency period, and lack of preferred integration sites in tumors. A second human virus, called HTLV-II, was identified in the Mo T cell line, derived in 1976 from the spleen of a patient with T cell-variant hairy cell leukemia [2, 10]. Other isolates of HTLV-I and -II have since been obtained around the world. Both viruses not only transform normal T-lymphocytes but might also very well be involved in a number of degenerative diseases of the nervous system.

Keywords

Long Terminal Repeat Bovine Leukemia Virus P34x Expression Persistent Lymphocytosis Enzootic Bovine Leukosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. Willems
    • 1
    • 2
  • R. Kettmann
    • 1
    • 2
  • D. Portetelle
    • 1
    • 2
  • A. Burny
    • 1
    • 2
  1. 1.Faculty of AgronomyGemblouxBelgium
  2. 2.Department of Molecular BiologyUniversity of BrusselsRhode-Saint-GenèseBelgium

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