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Tierexperimentelle Modelle zur Therapie des Prostatakarzinoms

  • K. M. Schrott
  • R. Walther
Conference paper

Zusammenfassung

Für Therapiestudien des Prostatakarzinoms stellen wir an Tiermodelle die im folgenden aufgezählten Anforderungen:
  • Spontaner Ursprung

  • Auftreten bei alten Tieren

  • Herkunft von Prostatagewebe

  • Adenokarzinom

  • Langsam wachsend

  • Histologische Ähnlichkeit mit Human-Prostatakarzinom

  • Vergleichbare biochemische Eigenschaften (Phosphatasen↑)

  • Metastasierung in Knochen, Lymphknoten

  • Hormonempfindlichkeit: androgenabhängiges Wachstum.

  • Parallelität im therapeutischen Ansprechen
    1. a)

      bei Hormontherapie (fakultativ auch mit Hormonresistenz)

       
    2. b)

      Chemotherapie

       
    3. c)

      Strahlentherapie

       
  • Heterogene Biologie (nach Differenzierungsgrad, Hormonsensibilität, -Resistenz) entsprechend der menschlichen Karzinomvielfalt.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • K. M. Schrott
  • R. Walther

There are no affiliations available

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