Abstract
The prenatal development of the CNS can be disturbed by a number of genetic (inherited) and nongenetic (congenital) factors. However, the etiologic classification of the various malformations remains uncertain in many cases, both in terms of the primary cause and the timing of the insult. Adams and Victor [3] suggest classifying malformations according to possible causative factors:
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Malformations caused by the mutation of a single gene
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Malformations in which a hereditary disposition coincides with nongenetic and usually indeterminate factors
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Malformations associated with chromosomal abnormalities
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Malformations due entirely to exogenous factors (virus, other infectious agents, X-irradiation, toxins)
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Malformations of undetermined cause (60% of cases)
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Huk, W.J. (1990). Malformations of the CNS. In: Magnetic Resonance Imaging of Central Nervous System Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72568-5_7
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