The Prevalence of Increased Pulmonary Arterial Pressure Among Sleep Apneics

  • T. Podszus
  • I. Becker
Conference paper


Alveolar hypoventilation is one of the factors in the pathogenesis of pulmonary hypertension [1-3]. Vasoconstriction of the precapillary pulmonary arteries due to hypoxia, a mechanism described by von Euler and Liljestrand [4], is regarded as the cause. This active form of precapillary pulmonary hypertension [2] is found in patients with chronic obstructive lung disease, pickwickian patients, and otherwise healthy subjects who exhibit pulmonary hypertension under conditions of high altitude.


Pulmonary Hypertension Sleep Apnea Cardiac Index Pulmonary Artery Pressure Pulmonary Vascular Resistance 
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  1. 1.
    Blount SG, Grover RF (1978) Pulmonary hypertension. In: Hurst JW (ed) The heart, arteries and veins. Mc Graw-Hill, New York, pp 1456–1472Google Scholar
  2. 2.
    Widimsky J (1981) Pulmonale Hypertonie. Thieme, StuttgartGoogle Scholar
  3. 3.
    Grossman W, Braunwald E (1980) Pulmonary hypertension. In: Braunwald E (ed) Heart disease. Saunders, Philadelphia, pp 835–851Google Scholar
  4. 4.
    von Euler US, Liljestrand G (1946) Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12:301–320CrossRefGoogle Scholar
  5. 5.
    Burwell CS, Rubin ED, Whaley RE, Bickelmann A (1956) Extreme obesity associated with alveolar hypoventilation: a pickwickian syndrome. Am J Med 21:811–818PubMedCrossRefGoogle Scholar
  6. 6.
    Jung R, Kuhlo W (1965) Neurophysiological studies of abnormal night sleep and the pickwickian syndrome. In: Alkert K, Bally C (eds) Progress in brain research, vol 18. Elsevier, Amsterdam, pp 140–157Google Scholar
  7. 7.
    Tilkian AG, Guilleminault C, Schroeder JS, Lehrman KL, Blair-Simmons F, Dement WC (1976) Hemodynamics in sleep-induced apnea. Studies during wakefulness and sleep. Ann Intern Med 85:714–719PubMedGoogle Scholar
  8. 8.
    Podszus T, Bauer W, Mayer J, Penzel T, Peter JH, von Wichert P (1986) Sleep apnea and pulmonary hypertension. Klin Wochenschr 64:131–134PubMedCrossRefGoogle Scholar
  9. 9.
    Peter JH, Becker E, Fuchs E, Meinzer K, von Wichert P (1982) Ambulante transkutane Langzeitregistrierung von arterieller Sauerstoffspannung und Herzrhythmusstörungen bei Patienten mit Schlafapnoesyndrom. Verh Dtsch Inn Med 88:390–393Google Scholar
  10. 10.
    Peter JH (1985) Holter monitoring technique in a comprehensive approach: ambulatory monitoring of sleep apnea. In: Hombach V, Hilger HH (eds) Holter monitoring technique. Schattauer, Stuttgart, pp 127–149Google Scholar
  11. 11.
    Guilleminault C, Tilkian A, Dement WC (1976) The sleep apnea syndromes. Am Rev Med 27:465–484CrossRefGoogle Scholar
  12. 12.
    Schroeder JS, Motta J, Guilleminault (1978) Hemodynamic studies in sleep apnea. In: Guilleminault C (ed) Sleep apnea syndromes. Liss, New York, pp 177–196Google Scholar
  13. 13.
    Coccagna G, Mantovani M, Brignani F, Parchi C, Lugaresi E (1972) Continuous recording of the pulmonary and systemic arterial pressure during sleep in syndromes of hypersomnia with periodic breathing. Bull Physio-Pathol Respir 8:1159–1172Google Scholar
  14. 14.
    Guilleminault C, Eldridge F, Simmon FB, Dement WC (1975) Sleep apnea syndrome. Can it induce hemodynamic changes? West J Med 123:7–16PubMedGoogle Scholar
  15. 15.
    Buda AJ, Schroeder JS, Guilleminault C (1981) Abnormalities of pulmonary artery wedge pressures in sleep-induced apnea. Int J Cardiol 1:67–74PubMedCrossRefGoogle Scholar
  16. 16.
    Podszus T, Mayer J, Penzel T, Peter JH, von Wichert P (1986) Nocturnal hemodynamics in patients with sleep apnea. Eur J Respir Dis 69 (Suppl 146):435–442Google Scholar
  17. 17.
    Scharf SM (1984) Influence of sleep state and breathing on cardio-vascular function. In: Saunders NA, Sullivan CE (eds) Sleep and breathing. Dekker, New York, pp 221–240Google Scholar
  18. 18.
    Podszus T, Mayer U, Penzel T, Peter JH, von Wichert P (1985) Hemodynamics during sleep in patients with sleep apnea. Sleep Res 14:198Google Scholar
  19. 19.
    Boysen PG, Block AJ, Wynne JW, Hunt LA, Flick MR (1987) Nocturnal pulmonary hypertension in patients with chronic obstructive pulmonary disease. Chest 76:536–542CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • T. Podszus
  • I. Becker

There are no affiliations available

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