Snoring as a Risk Factor for Ischaemic Heart Disease and Stroke in Men

  • M. Koskenvuo
  • J. Kaprio
  • T. Telakivi
  • M. Partinen
  • K. Heikkilä
  • S. Sarna


Heavy snoring, which is practically always present in obstructive sleep apnoea, seems to correlate with arterial hypertension [1-6]. During sleep, apnoeic patients may develop hypoxaemia and hypercapnia in association with a rise in pulmonary and systemic arterial pressure, and there may be increased susceptibility to cardiac arrhythmias [7-11]. Cardiac index decreases during an apnoeic episode and increases significantly on resumption of ventilation [12]. There is increasing evidence for a correlation of snoring with cardiovascular disease. Cross-sectional surveys have indicated an association with ischaemic heart disease (IHD) [13] and with angina pectoris [6]. A case-control study [14] of stroke patients found a relative risk (RR) of 2.8 for snoring, and 10.8 for habitual snoring. Prospective studies of snoring in relation to cardiovascular disease have not been reported.


Obstructive Sleep Apnea Sleep Apnea Angina Pectoris Ischaemic Heart Disease Obstructive Sleep Apnoea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Lugaresi E, Cirignotta F, Coccagna G, Piana C (1980) Some epidemiological data on snoring and cardiocirculatory disturbances. Sleep 3:221–224PubMedGoogle Scholar
  2. 2.
    Partinen M, Alihanka J, Lang H, Kalliomäki L (1983) Myocardial infarction in relation to sleep apneas. Sleep Res 12:272Google Scholar
  3. 3.
    Lavie P, Ben-Yosef R, Rubin AE (1984) Prevalence of sleep apnea among patients with essential hypertension. Am Heart J 108:373–376PubMedCrossRefGoogle Scholar
  4. 4.
    Kales A, Bixler E, Cadieux RJ et al (1984) Sleep apnoea in a hypertensive population. Lancet 11:1005–1008CrossRefGoogle Scholar
  5. 5.
    Fletcher EC, De Behnke RD, Lovoi MS, Gorin AB (1985) Undiagnosed sleep apnea in patients with essential hypertension. Ann Intern Med 103:190–195PubMedGoogle Scholar
  6. 6.
    Koskenvuo M, Kaprio J, Partinen M et al (1985) Snoring as a risk factor for hypertension and angina pectoris. Lancet 1:893–896PubMedCrossRefGoogle Scholar
  7. 7.
    Schroeder JS, Motta J, Guilleminault C (1978) Hemodynamic studies in sleep apnoea. In: Guilleminault C, Dement WC (eds) Sleep apnea syndromes. Liss, New York, pp 177–196Google Scholar
  8. 8.
    Tilkian AG, Motta J, Guilleminault C (1978) Cardiac arrythmias in sleep apnoea. In: Guilleminault C, Dement WC (eds) Sleep apnoea syndromes. Liss, New York, pp 197–210Google Scholar
  9. 9.
    Deedwania PC, Swiryn S, Dhingra RC, Rosen KM (1979) Nocturnal atrioventricular block as a manifestation of sleep apnea syndrome. Chest 76:319–321PubMedCrossRefGoogle Scholar
  10. 10.
    Motta J, Guilleminault C (1985) Cardiac dysfunction during sleep. Ann Clin Res 17:190–198PubMedGoogle Scholar
  11. 11.
    Ingbar DH, Gee JBL (1985) Pathophysiology and treatment of sleep apnea. Annu Rev Med 36:369–395PubMedCrossRefGoogle Scholar
  12. 12.
    Guilleminault C, Motta J, Mihm F, Melvin K (1986) Obstructive sleep apnea and cardiac index. Chest 89:331–334PubMedCrossRefGoogle Scholar
  13. 13.
    Norton PG, Dunn EV (1985) Snoring as a risk factor for disease: an epidemiological survey. Br Med J 291:630–632CrossRefGoogle Scholar
  14. 14.
    Partinen M, Palomäki H (1985) Snoring and cerebral infarction. Lancet II:1325–1326CrossRefGoogle Scholar
  15. 15.
    Penttilä A (1975) Mortality from arteriosclerotic and other degenerative heart diseases in Finland in 1968. Health services research of the National Board of Health in Finland 12/1974, HelsinkiGoogle Scholar
  16. 16.
    Koskenvuo M, Kaprio J, Kesäniemi A, Sarna S (1980) Differences in mortality from ischaemic heart disease by marital status and social class. J Chronic Dis 33:95–106PubMedCrossRefGoogle Scholar
  17. 17.
    Heliövaara M, Reunanen A, Aromaa A, et al (1984) Validity of hospital discharge data in a prospective epidemiologic study on stroke and myocardial infarction. Acta Med Scand 216:309–316PubMedCrossRefGoogle Scholar
  18. 18.
    BMDP statistical software (1981) Dixon WJ, Brown MD, Engelman L et al (eds) University of California Press, Los AngelesGoogle Scholar
  19. 19.
    Telakivi T, Kajaste S, Salmi T et al (1986) Breathing and blood oxygen satturation during sleep, cardiovascular disease and cognitive function in snorers and non-snorers. 8th European Congress of sleep research, Szeged (Hungary), Sept. 1–5. p 362Google Scholar
  20. 20.
    Koskenvuo M, Kaprio J, Kesäniemi A et al (1986) Alcohol-related diseases associated with ischaemic heart disease: a three-year follow-up of middle-aged male hospital patients. Alcohol Alcoholism 21: (to be published)Google Scholar
  21. 21.
    Lavie P (1983) Sleep apnoea in industrial workers. In: Guilleminault C, Lugaresi E (eds) Sleep/wake disorders: natural history,epidemiology, and long-term evolution. Raven, New York, pp 127–135Google Scholar
  22. 22.
    Peter JH, Siegrist J, Podszus T et al (1985) Prevalence of sleep apnea in healthy industrial workers. Klin Wochenschr 63:807–812PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. Koskenvuo
  • J. Kaprio
  • T. Telakivi
  • M. Partinen
  • K. Heikkilä
  • S. Sarna

There are no affiliations available

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