Han/Wistar Rats Are Exceptionally Resistant to TCDD. II.
In previous studies from this laboratory, adult male Han/Wistar rats were shown to be very resistant to the lethal effect of a single dose of 2,3,7,8-tetrachlorodi-benzo-p-dioxin (TCDD). Doses of 125–1400 µg/kg body weight caused a dramatic decrease in feed consumption and a consecutive decrease of 20%–25% in the body weight. Only 2/40 animals died, however, and none in the highest dose group. Hence, the lethal dose for 50% of the group (LD50) must have been over 1400 µg/kg in this strain in contrast to Sprague-Dawley and Long-Evans strains, which have an LD50 of 50 µg/kg or lower. In the present study higher doses were tested to obtain an indication of the LD50 in the Han/Wistar strain.
KeywordsBrown Adipose Tissue High Dose Group Feed Consumption Ventral Prostate National Public Health
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