Han/Wistar Rats Are Exceptionally Resistant to TCDD. II.

  • R. Pohjanvirta
  • J. Tuomisto
Conference paper
Part of the Archives of Toxicology, Supplement book series (TOXICOLOGY, volume 11)


In previous studies from this laboratory, adult male Han/Wistar rats were shown to be very resistant to the lethal effect of a single dose of 2,3,7,8-tetrachlorodi-benzo-p-dioxin (TCDD). Doses of 125–1400 µg/kg body weight caused a dramatic decrease in feed consumption and a consecutive decrease of 20%–25% in the body weight. Only 2/40 animals died, however, and none in the highest dose group. Hence, the lethal dose for 50% of the group (LD50) must have been over 1400 µg/kg in this strain in contrast to Sprague-Dawley and Long-Evans strains, which have an LD50 of 50 µg/kg or lower. In the present study higher doses were tested to obtain an indication of the LD50 in the Han/Wistar strain.


Toxicity Corn Cage Toxicology Thyroxine 


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  1. Chapman DE, Schiller CM (1985) Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice. Toxicol Appl Phar 78:147–157CrossRefGoogle Scholar
  2. Peterson RE, Potter CL, Moore RW (1984) The wasting syndrome and hormonal alterations in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity. In: Lowrance WW (ed) Public health risks of the dioxins. Kaufmann, Los Altos, pp 315–349Google Scholar
  3. Pohjanvirta R, Tuomisto J, Vartiainen T, Rozman K (1987) Han/Wistar rats are exceptionally resistant to TCDD. I. Pharmacol and Toxicol 60:145–150CrossRefGoogle Scholar
  4. Potter CL, Menahan LA, Peterson RE (1986) Relationship of alterations in energy metabolism to hypophagia in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 6:89–97PubMedCrossRefGoogle Scholar
  5. Rozman K, Rozman T, Greim H (1984) Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlo-rodibenzo-p-dioxin ( TCDD) induced toxicity. Toxicol Appl Pharmacol 72:372–376PubMedCrossRefGoogle Scholar
  6. Seefeld MD, Keesey RE, Peterson RE (1984) Body weight regulation in rats treated with 2,3,7,8-tetra-chlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 76:526–536PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • R. Pohjanvirta
    • 1
  • J. Tuomisto
    • 1
  1. 1.Department of Environmental Hygiene and ToxicologyNational Public Health InstituteKuopioFinland

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