An Evaluation of the Toxichromotest, a Bacterial Toxicity Bioassay, and an Assessment of its Potential Use in Human Poisoning

  • P. Lympany
  • S. L. Cassidy
  • J. A. Henry
Conference paper
Part of the Archives of Toxicology, Supplement book series (TOXICOLOGY, volume 11)

Abstract

A novel bacterial toxicity bioassay, the Toxichromotest, has recently been pro­posed (Reinhartz et al., in press). It is based on the ability of toxic materials to inhibit the de novo synthesis of an inducible enzyme, β-galactosidase, in a mutant strain of Escherichia coli (E. coli) after lyophilic stress.

Keywords

Toxicity Cortisol Histamine Tetracycline Erythromycin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Reinhartz A, Lampert I, Herzberg M, Fish F (1987) A new, short-term, sensitive bacterial assay kit for the detection of toxicants. Toxicity Assessment 2(2):in press for may 1987Google Scholar
  2. Woods PB, Robinson ML (1981) An investigation of the comparative liposolubilities of beta-adreno-ceptor blocking agents. J Pharm Pharmacol 33:172–173PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • P. Lympany
    • 1
  • S. L. Cassidy
    • 1
  • J. A. Henry
    • 1
  1. 1.National Poisons UnitGuy’s HospitalLondonUK

Personalised recommendations