Structure Activity Requirements for Induction of Peroxisomal Enzyme Activities in Primary Rat Hepatocyte Cultures

  • D. F. V. Lewis
  • B. G. Lake
  • T. J. B. Gray
  • S. D. Gangolli
Conference paper
Part of the Archives of Toxicology, Supplement book series (TOXICOLOGY, volume 11)

Abstract

A range of apparently structurally diverse compounds are known to produce liver enlargement and hepatic peroxisome proliferation in rodents (Reddy and Lalwani 1983). As the in vivo effects of peroxisome proliferators may be demonstrated in cell culture (Gray et al. 1983), the structure activity requirements for induction of peroxisomal enzyme activities by a series of 13 compounds in primary rat hepatocyte cultures has been studied.

Keywords

DMSO Carboxyl Carbonyl Dium Collagenase 

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References

  1. Bingham RC, Dewar MJS, Lo DH (1975) Ground states of molecules. XXV. MINDO/3. An improved version of the MINDO semiempirical SCF-MO method. J Amer Chem Soc 97:1285–1293CrossRefGoogle Scholar
  2. Gray TJB, Lake BG, Beamand JA, Foster JR, Gangolli SD (1983) Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 67:15–25PubMedCrossRefGoogle Scholar
  3. Reddy JK, Lalwani ND (1983) Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit Rev Toxicol 12:1–58PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • D. F. V. Lewis
    • 1
  • B. G. Lake
    • 2
  • T. J. B. Gray
    • 2
  • S. D. Gangolli
    • 2
  1. 1.Department of BiochemistryUniversity of SurreyGuildfordUK
  2. 2.The British Industrial Biological Research AssociationCarshaltonUK

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