Structure Activity Requirements for Induction of Peroxisomal Enzyme Activities in Primary Rat Hepatocyte Cultures
Part of the
Archives of Toxicology, Supplement
book series (TOXICOLOGY, volume 11)
A range of apparently structurally diverse compounds are known to produce liver enlargement and hepatic peroxisome proliferation in rodents (Reddy and Lalwani 1983). As the in vivo effects of peroxisome proliferators may be demonstrated in cell culture (Gray et al. 1983), the structure activity requirements for induction of peroxisomal enzyme activities by a series of 13 compounds in primary rat hepatocyte cultures has been studied.
KeywordsQuantitative Structure Activity Relationship Peroxisome Proliferators Molecular Orbital Calculation Clofibric Acid Peroxisomal Fatty Acid
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