Abstract
A range of apparently structurally diverse compounds are known to produce liver enlargement and hepatic peroxisome proliferation in rodents (Reddy and Lalwani 1983). As the in vivo effects of peroxisome proliferators may be demonstrated in cell culture (Gray et al. 1983), the structure activity requirements for induction of peroxisomal enzyme activities by a series of 13 compounds in primary rat hepatocyte cultures has been studied.
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References
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Gray TJB, Lake BG, Beamand JA, Foster JR, Gangolli SD (1983) Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 67:15–25
Reddy JK, Lalwani ND (1983) Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit Rev Toxicol 12:1–58
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© 1987 Springer-Verlag
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Lewis, D.F.V., Lake, B.G., Gray, T.J.B., Gangolli, S.D. (1987). Structure Activity Requirements for Induction of Peroxisomal Enzyme Activities in Primary Rat Hepatocyte Cultures. In: Chambers, C.M., Chambers, P.L., Davies, D.S. (eds) Mechanisms and Models in Toxicology. Archives of Toxicology, Supplement, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72558-6_5
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DOI: https://doi.org/10.1007/978-3-642-72558-6_5
Publisher Name: Springer, Berlin, Heidelberg
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