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Sex-Related Interactions of Cadmium and Lead in Changing Cardiovascular Homeostasis and Tissue Metal Levels of Chronically Exposed Rats

  • M. Carmignani
  • V. N. Finelli
  • P. Boscolo
  • P. Preziosi
Conference paper
Part of the Archives of Toxicology, Supplement book series (TOXICOLOGY, volume 11)

Abstract

The mechanisms by which chronic exposure to lead (Pb), cadmium (Cd) or Pb plus Cd may affect cardiovascular homeostasis are still controversial (Iannaccone et al. 1981; Boscolo et al. 1981; Carmignani et al. 1983). Pb determined sympathetic hyperactivity, baroreflex hyposensitivity, vagal parasympathetic hypofunc-tion, and increased cardiovascular responsiveness to angiotensin II and catecholamines in male Sprague-Dawley rats that received 50 µg/ml of the metal (as acetate) in drinking water for 160–180 days (Iannaccone et al. 1981). Pb also reduced the urinary kallikrein and affected the plasma renin activities of Pb-exposed workers (Boscolo et al. 1978). The mechanisms underlying the cardiac and vascular modifications induced by chronic exposure of both humans and laboratory animals to Cd have been previously reviewed (Carmignani and Boscolo 1984, 1985; Boscolo and Carmignani 1986). Pb and Cd may have additive effects in inducing heart-related diseases or arterial hypertension (Carmignani and Boscolo 1984; Boscolo and Carmignani 1986). However, these additive effects of Pb and Cd were not confirmed in a study carried out on male Sprague-Dawley rats treated with 20 µg/ml of Cd (as acetate) and/or 50 µg/ml of Pb (as acetate) in drinking water for 180-210 days. In this study Cd seemed to act by predominantly peripheral effector mechanisms, while Pb showed central neurogenic actions; both metals altered specifically the levels of zinc (Zn) and copper (Cu) in kidney and brain (Carmignani et al. 1983).

Keywords

Plasma Renin Activity Cardiovascular Responsiveness Cardiovascular Homeostasis Urinary Kallikrein Bilateral Carotid Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Boscolo P, Carmignani M (1986) Mechanisms of cardiovascular regulation in male rabbits chronically exposed to cadmium. Br J Ind Med 43:605–610PubMedGoogle Scholar
  2. Boscolo P, Porcelli G, Cecchetti G, Salimei E, Iannaccone A (1978) Urinary kallikrein activity of workers exposed to lead. Br J Ind Med 35:226–230PubMedGoogle Scholar
  3. Boscolo P, Porcelli G, Carmignani M, Finelli VN (1981) Urinary kallikrein and hypertension in cadmium-exposed rats. Toxicol Lett 7:189–194PubMedCrossRefGoogle Scholar
  4. Carmignani M, Boscolo P (1984) Cardiovascular responsiveness to physiological agonists of male rats made hypertensive by long-term exposure to cadmium. Sci Total Environ 34:19–33PubMedCrossRefGoogle Scholar
  5. Carmignani M, Boscolo P (1985) Long-term exposure to cadmium and cardiovascular alterations in the rabbit. Arch Toxicol [Suppl] 8:322–326CrossRefGoogle Scholar
  6. Carmignani M, Boscolo P, Ripanti G, Finelli VN (1983) Effects of chronic exposure to cadmium and/ or lead on some neurohumoral mechanisms regulating cardiovascular function in the rat. In: Proceedings of the international conference on heavy metals in the environment (German; Müller, Ed.) Heidelberg, September 1983. CEP, Edinburgh, pp 557–560Google Scholar
  7. Iannaccone A, Carmignani M, Boscolo P (1981) Neurogenic and humoral mechanisms in arterial hypertension of chronically lead-exposed rats. Med Lav 1:13–21Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. Carmignani
    • 1
    • 2
  • V. N. Finelli
    • 3
  • P. Boscolo
    • 4
  • P. Preziosi
    • 5
  1. 1.Department of Cell Biology and PhysiologyUniversity of L’AquilaL’AquilaItaly
  2. 2.Institute of Pharmacology, CatholicUniversity School of Medicine and SurgeryRomeItaly
  3. 3.Department of ChemistryFlorida Atlantic UniversityBoca RatonUSA
  4. 4.Chair of Industrial ToxicologyUniversity of ChietiChietiItaly
  5. 5.Institute of PharmacologyCatholic University School of Medicine and SurgeryRomeItaly

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