Teratogenicity Testing in Vitro: Status of Validation Studies

  • N. A. Brown
Part of the Archives of Toxicology, Supplement book series (TOXICOLOGY, volume 11)

Abstract

Alternatives to the standard method of using pregnant mammals to test for teratogenicity have been the subject of extensive review and comment in recent years (see, for example, Shepard et al. 1983; Johnson 1984; Sadler and Warner 1984; Brown and Freeman 1984; Neubert et al. 1985). There has been much debate on the uses and limitations of alternative tests, although no consensus has yet emerged. Regardless of these considerations, several test systems are commercially available and being used for the initial estimation of teratogenicity (variously termed “screening” or “prescreening”). The purpose of this study was to examine the current status of validation studies of the various model systems which have been proposed as potential tests. There are many other aspects of this field which will not be considered here: for example, the practicality of tests and the scientific basis of test design. The above reviews can be consulted for further discussion of these topics. It is appropriate, however, to make clear the limitations of any in vitro test for teratogenicity. (Strictly speaking, several of the models proposed as tests are not “in vitro” systems, but the terms “alternative test” and “in vitro test” are used synonymously in this paper.)

Keywords

Aspirin Testosterone Caffeine Pyrene Indomethacin 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • N. A. Brown
    • 1
  1. 1.MRC Experimental Embryology and Teratology UnitMedical Research Council LaboratoriesCarshaltonUK

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