Skip to main content
SpringerLink
Log in

Atrophy, Testis, Rat

  • Chapter
Book cover Genital System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Severely atrophic testes are small, soft, and covered by a smooth but wrinkled, rubbery, yellow-tan tunica albuginia. The testicular mass may be decreased by more than 50%. (Normal testes in a 500-g rat weigh approximately 2–2.25 g each.) Upon cutting through the tunica albuginia, a scant amount of edema fluid may be released. The seminiferous tubules are loosely held together. In very old rats of some strains (particularly the Fisher 344 strain), small gray and white nodules may be present within the interstitial tissue. Testicular atrophy is usually bilateral, but marked unilateral atrophy can occur. Atrophic changes occur over a continuum of severity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anver MR, Cohen BJ (1979) Lesions associated with aging. In: Baker HJ, Lindsey JR, Weisbroth SH (eds) The laboratory rat, voll. Academic, New York, chap 14

    Google Scholar 

  • Bivin WS, Crawford MP, Brewer NR (1979) Morphophysiology. In: Baker HJ, Lindsey JR, Weisbroth SH (eds) The laboratofy rat. vol 1. Academic, New York, chap 4

    Google Scholar 

  • Burek JD (1978) Pathology of aging rats. CRC, West Palm Beach, pp 129–138

    Google Scholar 

  • Chatterjee A (1966) Prevention of testicular degeneration in alloxanized rats by use of cortisone. Acta Anat (Basel) 63:591–595

    Article  CAS  Google Scholar 

  • Chatterjee A, Mukherji M (1966) Prevention of gonadal degeneration in male diabetic rats by the use of insulin. Endokrinologie 50:11–14

    PubMed  CAS  Google Scholar 

  • Chokyu K (1965) Studies on diabetes mellitus and functions of the male sexual glands. Acta Urol Jpn 11: 850–876

    CAS  Google Scholar 

  • Cohen BJ, de Vries MJ (1969) Giant cells in the rat testes after accidental and experimental thermal injury. Pathol Eur 4: 336–344

    PubMed  CAS  Google Scholar 

  • Coleman GL, Barthold SW, Osbaldiston GW, Foster SJ, Jonas AM (1977) Pathological changes during aging in barrier-reared Fischer 344 male rats. J Gerontol 32: 258–278

    PubMed  CAS  Google Scholar 

  • Davis JR, Firlit CF (1966) The germinal epithelium of cryptorchid testes experimentally induced in prepubertal and adult rats. Fértil Steril 17:187–200

    CAS  Google Scholar 

  • Ellis LC (1970) Radiation effects. In: Johnson AD, Gomes WR, Vandemark NL (eds) The testis, vol 3. Academic, New York, pp 333–376

    Google Scholar 

  • Faerman I, Vilar O, Rivarola MA, Rosner JM, Jadzinsky MN, Fox D, Lloret AP, Bemstein-Hahn L, Saraceni D (1972) Impotence and diabetes: studies of androgenic function in diabetic impotent males. Diabetes 21: 23–30

    PubMed  CAS  Google Scholar 

  • Fechheimer NS (1970) Genetic aspects of testicular development and function. In: Johnson AD, Gomes WR, Vandemark NL (eds) The testis, vol 3. Academic, New York, chap l,pp 2–40

    Google Scholar 

  • Federlin K, Schöffling K, Neubronner P, Pfeiffer EF (1965) Histometrische Untersuchungen am Hodengewebe des Diabetikers mit Keimdrüsenunterfunktion. Diabetologia 1:85–90

    Article  Google Scholar 

  • Gomes WR (1970) Chemical agents affecting testicular function and male fertility. In: Johnson AD, Gomes WR, Vandemark NL (eds) The testis, vol 3. Academic, New York, chap 11, pp 483–554

    Google Scholar 

  • Gunn SA, Gould TC (1970) Cadmium and other mineral elements. In: Johnson AD, Gomes WR, Vandemark NL (eds) The testis, vol 3. Academic, New York, chap 10, pp 378–481

    Google Scholar 

  • Irby DC, Kerr JB, Risbridger GP, de Kretser DM (1984) Seasonally and experimentally induced changes in the testicular function of the Australian bush rat (Rattus fuscipes). J Reprod Fértil 70: 657–666

    Article  PubMed  CAS  Google Scholar 

  • Irisawa S, Shirai M, Matsushita S, Kagayama M, Ichijo S (1966) Sexual disturbances in diabetes. Tohoku J Exp Med 88:311–326

    Article  PubMed  CAS  Google Scholar 

  • Jackson CM (1925) Effects on the male reproductive tract. In: The effects of inanition and malnutrition upon growth and structure. Blakiston, Philadelphia, chap 25

    Chapter  Google Scholar 

  • Jackson H (1959) Antifertility substances. Pharmacol Rev 11:135–172

    PubMed  CAS  Google Scholar 

  • Kerr JB, Keogh EJ, Hudson B, Whipp GT, de Kretser DM (1980) Alterations in spermatogenic activity and hormonal status in a seasonally breeding rat, Rattus fuscipes. Gen Comp Endocrinol 40: 78–88

    Article  PubMed  CAS  Google Scholar 

  • Keys AB, Brozek J, Henschel A, Mickelsen O, Taylor HL (1950) The biology of human starvation, vol 1. University of Minnesota Press, Minneapolis

    Google Scholar 

  • Kuber W (1982) Testicular tumor and cryptorchidism. Eur Urol 8:280–283

    PubMed  CAS  Google Scholar 

  • Lema BE, Foglia VG, Fernandez Collazo E (1965) Lesiones histologicas testiculares en la rata diabetica. Rev Soc Argent Biol 41:197–203

    PubMed  CAS  Google Scholar 

  • Leeson TS, Leeson CR (1970) Experimental cryptorchidism in the rat. A light and electron microscope study. Invest Urol 8:127–144

    PubMed  CAS  Google Scholar 

  • Levin HS (1979) Testicular biopsy in the study of male infertility: its current usefulness, histologic techniques, and prospects for the future. Hum Pathol 10:569–584

    Article  PubMed  CAS  Google Scholar 

  • Lützen L, Ueberberg H (1973) A study on morphological changes in the testes of old albino rats. Beitr Pathol 149: 377–385

    Article  PubMed  Google Scholar 

  • Mason KE (1933) Differences in testis injury and repair after vitamin A-deficiency, vitamin E-deficiency and inanition. Am J Anat 52:153–239

    Article  CAS  Google Scholar 

  • Mason KE (1940) Minimal requirements of male and female rats for vitamin E. Am J Physiol 131: 268–280

    CAS  Google Scholar 

  • Mason KE, Horwitt MK (1972) Effects of deficiency in animals. In: Sebrell WH Jr, Harris RS (eds) The vitamins: chemistry, physiology, pathology and methods, vol 5. Academic, New York, chap 16, pp 272–292

    Google Scholar 

  • Mason KE, Mauer SI (1975) Reversible testis injury in the vitamin E-deficient hamster. J Nutr 105:484–490

    PubMed  CAS  Google Scholar 

  • Mason KE, Bums WA, Smith JC Jr (1982) Testicular damage associated with zinc deficiency in pre- and postpu- bertal rats: response to zinc repletion. J Nutr 112: 1019–1028

    PubMed  CAS  Google Scholar 

  • Murray FT, Cameron DF, Orth JM (1983) Gonadal dysfunction in the spontaneously diabetic BB rat. Metabolism 32 (Suppl 1): 141–147

    Article  PubMed  CAS  Google Scholar 

  • Nelson JS (1980) Pathology of vitamin E deficiency. In: Machlin LJ (ed) Vitamin E: a comprehensive treatise. Dekker, New York, chap 7, pp 397–428

    Google Scholar 

  • Nistal M, Paniagua R, Diez-Pardo JA (1980) Histologic classification of undescended testes. Hum Pathol 11: 666–674

    Article  PubMed  CAS  Google Scholar 

  • Oksanen A (1975) Testicular lesions of streptozotocin diabetic rats. Horm Res 6:138–144

    Article  PubMed  CAS  Google Scholar 

  • Orent ER, McCollum EV (1931) Effects of deprivation of manganese in the rat. J Biol Chem 92: 651–678

    CAS  Google Scholar 

  • Rosenmann E, Palti Z, Teitelbaum A, Cohen AM (1974) Testicular degeneration in genetically selected sucrosefed diabetic rats. Metabolism 23: 343–348

    Article  PubMed  CAS  Google Scholar 

  • Russfield AB (1967) Pathology of the endocrine glands, ovary and testis of rats and mice. In: Cotchin E, Roe FJC (eds) Pathology of laboratory rats and mice. Black- well, Oxford chap 14

    Google Scholar 

  • Saksena SK, Lau IF, Chang MC (1979) Age dependent changes in the sperm population and fertility in the male rat. Exp Aging Res 5: 373–381

    Article  PubMed  CAS  Google Scholar 

  • Scaffidi L, Rotolo G (1974) II danno testicolare nel diabete sperimentale da allossana nel ratto. Minerva Med 65: 4477–4484

    PubMed  CAS  Google Scholar 

  • Scaffidi L, Rotolo G, Scaffidi A (1975) Effetto protettivo di alcuni ormoni (insulina, testosterone, HCG) sul danno testicolare nel diabete da allossana nel ratto. Minerva Med 66: 4586–4591

    PubMed  CAS  Google Scholar 

  • Schöffüng K (1971) Diabetes mellitus and male gonadal function. In: Rodriguez RR, Vallance-Owen J (eds) Dia- betes: proceedings of the seventh congress of the International Diabetes Federation. Excerpta Medica, Amsterdam

    Google Scholar 

  • Schöffling K, Federlin K, Schmitt W, Pfeiffer EF (1967) Histometric investigations on the testicular tissue of rats with alloxan diabetes and Chinese hamsters with spontaneous diabetes. Acta Endocrinol (Copenh) 54: 335–346

    Google Scholar 

  • Singhal KC, Rastogi GK, Aikat BK, Chhuttani PN (1969) Testicular histology in diabetics with impotence. Indian J Pathol Bacteriol 12:145–148

    PubMed  CAS  Google Scholar 

  • Siperstein DM (1921) The effects of acute and chronic inanition upon the development and stmcture of the testis in the albino rat. Anat Rec 20: 355–391

    Article  Google Scholar 

  • Steinberger E (1970) Effect of altered blood blow on the testis. In: Johnson AD, Gomes WR, Vandemark NL (eds) The testis, vol 3. Academic, New York, chap 8, pp 313–332

    Google Scholar 

  • Swensen SR, Telford IR (1973) Lipofuscin distribution and histological lesions in the vitamin E deficient cotton rat (Sigmodon hispidus hispidus). Arch Histol Jpn 35: 327–341

    Article  PubMed  CAS  Google Scholar 

  • Thiel W, Low O, Schreiber G (1981) Hodenbioptische Untersuchungen bei männlichen Diabetikern. Z Gesamte Inn Med 36:917–920

    PubMed  CAS  Google Scholar 

  • Thompson JN (1970) The role of vitamin A in reproduction. In: DeLuca HF, Suttie JW (eds) The fat-soluble vitamins. University of Wisconsin Press, Madison, chap 18, pp 267–281

    Google Scholar 

  • Timmermans L (1974) Influence of antibiotics on spermatogenesis. J Urol 112: 348–349

    PubMed  CAS  Google Scholar 

  • Wong TW, Straus FH II, Warner NE (1973) Testicular biopsy in the study of male infertility. 1. Testicular causes of infertility. Arch Pathol 95:151–159

    PubMed  CAS  Google Scholar 

  • Wright JR, Yates AJ, Sharma HM, Shim C, Tigner RL, Tlübert P (1982) Testicular atrophy in the spontaneously diabetic BB Wistar rat. Am J Pathol 108: 72–79

    PubMed  Google Scholar 

Download references

Authors
  1. James R. Wright Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) & Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology, Emeritus) &  (Professor of Comparative Pathology)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wright, J.R. (1987). Atrophy, Testis, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Genital System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72550-0_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72550-0_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72552-4

  • Online ISBN: 978-3-642-72550-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation