Genital System pp 218-225 | Cite as

Atrophy, Testis, Rat

  • James R. WrightJr
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Severely atrophic testes are small, soft, and covered by a smooth but wrinkled, rubbery, yellow-tan tunica albuginia. The testicular mass may be decreased by more than 50%. (Normal testes in a 500-g rat weigh approximately 2–2.25 g each.) Upon cutting through the tunica albuginia, a scant amount of edema fluid may be released. The seminiferous tubules are loosely held together. In very old rats of some strains (particularly the Fisher 344 strain), small gray and white nodules may be present within the interstitial tissue. Testicular atrophy is usually bilateral, but marked unilateral atrophy can occur. Atrophic changes occur over a continuum of severity.


Seminiferous Tubule Multinucleated Giant Cell Testicular Atrophy Germinal Epithelium Maturation Arrest 
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© Springer-Verlag Berlin Heidelberg 1987

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  • James R. WrightJr

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