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Testicular Feminization, Testes, and Testicular Tumors, Rat, Mouse

  • Chapter
Genital System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

In both rats and mice with testicular feminization (Tfm/y), the entire reproductive tract, with the exception of small bilateral cryptorchid testes, is absent (Stanley et al. 1973). The undescended testes lie in the inguinal region or inside the abdominal cavity because the scrotum is not developed. The hairless portion of the scrotum also remains undeveloped in this syndrome. The cryptorchid testes, in both rats and mice with Tfm/y, are about one-fifth the testicular size of their normal littermates (Fig. 240). Leydig’s cell (interstitial cell) tumors develop in over 20% of the older male pseudohermaphrodite animals, usually between 1 and 3 years of age (Ohno 1974).

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References

  • Bardin CW, Bullock L, Schneider G, Allison JE, Stanley AJ (1970) Pseudohermaphrodite rat: end organ insensitivity to testosterone. Science 167:1136–1137

    Article  PubMed  CAS  Google Scholar 

  • Bardin CW, Bullock LP, Sherins RJ, Mowszowicz I, Blackbum W (1973) Androgen metabolism and mechanism of action in male pseudohermaphroditism: a study of testicular feminization. Recent Prog Horm Res 29: 65–109

    PubMed  CAS  Google Scholar 

  • Blackbum WR, Chung KW, Bullock L, Bardin CW (1973) Testicular feminization in the mouse: studies of Leydig cell stmcture and function. Biol Reprod 9: 9–23

    Google Scholar 

  • Bullock LP, Bardin CW, Ohno S (1971) The androgen insensitive mouse: absence of intranuclear androgen retention in kidney. Biochem Biophys Res Commun 44: 1537–1543

    Article  PubMed  CAS  Google Scholar 

  • Christensen AK, Fawcett DW (1966) The fine stmcture of the testicular interstitial cells in mice. Am J Anat 118: 551–571

    Article  PubMed  CAS  Google Scholar 

  • Chung KW (1980) Spontaneous testicular neoplasm in mice with testicular feminization. Cell Tissue Res 208: 47–56

    Article  PubMed  CAS  Google Scholar 

  • Chung KW, Allison JE (1979) Ultrastmctural and biochemical characteristics of Leydig cells from new- bom androgen-insensitive rats. Cell Tissue Res 196: 213–219

    Article  PubMed  CAS  Google Scholar 

  • Chung KW, Hamilton JB (1975) Testicular lipids in mice with testicular feminization. Cell Tissue Res 160:69–80

    Article  PubMed  CAS  Google Scholar 

  • Chung KW, Hamilton JB (1976) Further observations on the fine stmcture of Leydig cells in the testes of male pseudohermaphrodite rats. J Ultrastmct Res 54:68–75

    Article  CAS  Google Scholar 

  • Chung KW, Allison JE, Stanley AJ (1980) Stmctural and functional factors related to testicular neoplasia in feminized rats. JNCI 65:161–168

    PubMed  CAS  Google Scholar 

  • Fleeger JL, Bishop JP, Gomes WR, van Demark NL (1968) Testicular lipids. 1. Effect of unilateral cryptorchidism on lipid classes. J Reprod Fértil 15:1–7

    Article  PubMed  CAS  Google Scholar 

  • Gangolli SD (1982) Testicular effects of phthalate esters. Environ Health Perspect 45: 77–84

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Wilson JD (1972) Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization. J Clin Invest 51:1647–1658

    Article  PubMed  CAS  Google Scholar 

  • Huseby RA (1976) Estrogen-induced Leydig cell tumor in the mouse: a model system for the study of carcinogenesis and hormone dependency. J Toxicol Environ Health [suppl] 1:177–192

    CAS  Google Scholar 

  • Jacobs BB, Huseby RA (1967) Neoplasms occurring in aged Fischer rats, with special reference to testicular, uterine, and thyroid tumors. JNCI 39: 303–309

    PubMed  CAS  Google Scholar 

  • Lacy D (1960) Light and electron microscopy and its use in the study of factors influencing spermatogenesis in the rat. J R Microsc Soc 79: 209–225

    Article  PubMed  CAS  Google Scholar 

  • Lyon MF, Hawkes SG (1970) An x-linked gene for testicular feminization in the mouse. Nature 227:1217–1219

    Article  PubMed  CAS  Google Scholar 

  • Milin B, Roy AK (1973) Androgen ‘receptor’ in rat liver: cytosol ‘receptor’ deficiency in pseudohermaphrodite male rats. Nature [New Biol] 242: 248–250

    CAS  Google Scholar 

  • Morris JM (1953) The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol 65:1192–1211

    PubMed  CAS  Google Scholar 

  • Naftolin F, Judd HL (1973) Testicular feminization. In: Wynn RM (ed) Obstetrics and gynecology annual. Vol II, Appleton-Century-Crofts, New York, pp 1–24

    Google Scholar 

  • Ohno S (1971) Simplicity of mammalian regulatory systems inferred by single gene determination of sex pheno- types. Nature 234:134–137

    Article  CAS  Google Scholar 

  • Ohno S (1974) Animal model: x-linked testicular feminizetion mutation of the mouse. Am J Pathol 76:589–592

    Google Scholar 

  • Reddy JK, Ohno S (1981) Testicular feminization of the mouse: paucity of peroxisomes in Leydig cells of the testes. Am J Pathol 103: 96–104

    PubMed  CAS  Google Scholar 

  • Reddy JK, Svoboda DJ (1967 a) Lysosomal activity in Sertoli cells of normal and degenerating seminiferous epithelium of rat testis. Am J Pathol 51:1–18

    PubMed  CAS  Google Scholar 

  • Reddy JK, Svoboda DJ (1967 b) Alterations in rat testes due to an antispermatogenic agent. Light and electron microscopic study. Arch Pathol 84: 376–392

    PubMed  CAS  Google Scholar 

  • Reddy JK, Svoboda DJ (1972 a) Microbodies (peroxisomes): identification in interstitial cells of the testis. J Histochem Cytochem 20:140–142

    Article  PubMed  CAS  Google Scholar 

  • Reddy JK, Svoboda DJ (1972b) Microbodies (peroxisomes) in the interstitial cells of rodent testes. Lab Invest 26:657–665

    PubMed  CAS  Google Scholar 

  • Reddy JK, Svoboda DJ (1972 c) Microbodies in Leyding cell tumors of rat testis. J Histochem Cytochem 20: 793–803

    Article  PubMed  CAS  Google Scholar 

  • Reddy JK, Svoboda DJ, Azamoff DL, Dawar R (1973) Cadmium-induced Leydig cell tumors of rat testis: morphologic and cytochemical study. JNCI 51: 891–903

    PubMed  CAS  Google Scholar 

  • Stanley AJ, Gumbreck LG (1964) Male pseudohermaphroditism with feminizing testes in the male rat: a sex- linked recessive character. Program, 46th meeting of the Endocrine Society, p 40

    Google Scholar 

  • Stanley AJ, Gumbreck LG, Allison JE (1973) Male pseudohermaphroditism in the laboratory Norway rat I. Recent Prog Horm Res 29: 43–64

    PubMed  CAS  Google Scholar 

  • Vanha-Perttula T, Schneider G, Bardin CW, Stanley AJ, Gumbreck LG, Allison JE (1970) Testicular tumors in the androgen insensitive pseudohermaphrodite rat: histochemistry and steroid metabolism. Gynecol Obstet Invest 1:149–160

    Article  CAS  Google Scholar 

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Authors
  1. Janardan K. Reddy
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  2. M. Sambasiva Rao
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Editor information

Editors and Affiliations

  1. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) & Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology, Emeritus) &  (Professor of Comparative Pathology)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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© 1987 Springer-Verlag Berlin Heidelberg

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Reddy, J.K., Rao, M.S. (1987). Testicular Feminization, Testes, and Testicular Tumors, Rat, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Genital System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72550-0_32

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  • DOI: https://doi.org/10.1007/978-3-642-72550-0_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72552-4

  • Online ISBN: 978-3-642-72550-0

  • eBook Packages: Springer Book Archive

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