Lesions of the Female Genital System Caused by Diethylstilbestrol in Humans, Subhuman Primates, and Mice

  • Lorna D. Johnson
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


From 1945 to 1971 diethylstilbestrol (DES), a synthetic estrogen, was used extensively to prevent abortion in pregnant women. This use was discontinued when clear cell adenocarcinoma of the vagina in young women was associated with their exposure to DES in utero (Herbst et al. 1971). It is estimated that 500000 to 2000000 infants were exposed (Noller and Fish 1974). Examination of the exposed population has uncovered long-term effects in women, the oldest of whom are now beginning the 5th decade of life. These include a low incidence of the clear cell cancer (Herbst et al. 1977) and an increased incidence of cervical and vaginal intraepithelial squamous-cell neoplasia (Robboy et al. 1984).


Genital Tract Squamous Metaplasia Granular Cell Tumor Female Genital System Clear Cell Adenocarcinoma 
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© Springer-Verlag Berlin Heidelberg 1987

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  • Lorna D. Johnson

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