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Schock pp 37-52 | Cite as

Humorale Veränderungen im Schock: Die pathogenetische Bedeutung der Mediatoren

  • H. Neuhof
Part of the Klinische Anästhesiologie und Intensivtherapie book series (KAI, volume 33)

Zusammenfassung

Humorale Veränderungen sind eine lang bekannte Beobachtung im Schock. Hierzu zählen sowohl die metabolischen Reaktionen infolge des gestörten oxydativen Stoffwechsels als auch die Freisetzung der biogenen Amine Katecholamine, Histamin und Serotonin. Neben diesen “klassischen” Mediatoren hat in den letzten Jahren eine Reihe von Produkten aus den Kaskadensystemen (Gerinnungs-, Kallikrein-Kinin-, Komplementsystem), aus dem Arachidonsäuremetabolismus sowie toxische Sauerstoffprodukte und Proteasen vor allem aus Granulozyten eine zunehmende Bedeutung als Mediatoren für Störungen des Gefäßtonus und der Gefäßpermeabilität gewonnen. Die folgenden Ausführungen sollen daher ausschließlich diesen zur Zeit intensiv diskutierten Wirkstoffen gewidmet sein, die unter anderem für das Auftreten eines akuten Lungenversagens (ARDS) verantwortlich gemacht werden.

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© Springer-Verlag Berlin Heidelberg 1987

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  • H. Neuhof

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