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Prostanoids in the treatment of critical limb ischemia

  • J. D. Gruß
Conference paper

Abstract

Vascular surgery may claim to be one of the first applications in the endless history of prostanoids. When attending a congress in Japan, I remember seeing a number of young male patients with stages III and IV inoperable arterial occlusive disease being treated with prostaglandin E1 at the University Vascular Surgery Clinic Nagoya (S. Shionoya). Continous intra-arterial therapy was carried out with a timer-controlled roller pump so that the patient received on average 0.2 ng PGE1/kg body weight/min. I have to admit that I had only heard of this compound once during my studies and without any connection with a therapeutic active constituent. The treatment results reported by Shionoya appeared to me so convincing that I was able, with the assistance of the manufacturer Ono and the support of S. Shionoya himself and Flughafen AG Frankfurt to import the compound into Germany during the following months and years in a continuous refrigeration chain, in order to collect initial experience in inoperable stage III and IV arteriosclerosis patients (30, 42). Attempts to publish our first clinical experience with PGE1 in a serious German-language journal failed as a result of their absence of credibility, so that a first communication was only possible in 1978 in the form of a reader’s letter in the Deutsche Medizinische Wochenschrift and then only on the recommendation of my teacher, G. Schettler (19).

Keywords

Critical Limb Ischemia Arterial Occlusive Disease Peripheral Arterial Occlusive Disease Lumbar Sympathectomy Early Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1995

Authors and Affiliations

  • J. D. Gruß
    • 1
  1. 1.Dept. of Vascular SurgeryKurhess DiakonissenhausKasselGermany

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