Efficacy and tolerance of recombinant tissue-type plasminogen activator in patients with thrombotic or embolic occlusions of leg-arteries

  • F. A. Spengel
  • G. Küffer
  • H. Stiegler
Conference paper

Abstract

Dotter et al. [1] first described local clot lysis by intra-arterial perfusion of low-dose streptokinase into the occluding thrombus. Low-dose treatment with streptokinase or urokinase in acute or chronic occlusion of arteries of the leg has now become well established [2], With the availability of recombinant tissue-type plasminogen activator (rt-PA), possible advantages of this new thrombolytic agent in the treatment of occlusions in the arteries of leg and pelvis must be established.

Keywords

Ischemia Lactate Aspirin Heparin Alanine 

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1995

Authors and Affiliations

  • F. A. Spengel
    • 1
    • 2
  • G. Küffer
    • 3
  • H. Stiegler
    • 4
  1. 1.Medizinische PoliklinikUniversität MünchenGermany
  2. 2.Dept. of AngiologyLudwig-Maximilians University MunichMunichGermany
  3. 3.Radiologische Klinik und PoliklinikUniversität MünchenGermany
  4. 4.Städtisches Krankenhaus München-SchwabingGermany

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