Efficacy and tolerance of recombinant tissue-type plasminogen activator in patients with thrombotic or embolic occlusions of leg-arteries

  • F. A. Spengel
  • G. Küffer
  • H. Stiegler
Conference paper


Dotter et al. [1] first described local clot lysis by intra-arterial perfusion of low-dose streptokinase into the occluding thrombus. Low-dose treatment with streptokinase or urokinase in acute or chronic occlusion of arteries of the leg has now become well established [2], With the availability of recombinant tissue-type plasminogen activator (rt-PA), possible advantages of this new thrombolytic agent in the treatment of occlusions in the arteries of leg and pelvis must be established.


Popliteal Artery Thrombin Time Residual Stenosis Thrombotic Occlusion Occlude Thrombus 
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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1995

Authors and Affiliations

  • F. A. Spengel
    • 1
    • 2
  • G. Küffer
    • 3
  • H. Stiegler
    • 4
  1. 1.Medizinische PoliklinikUniversität MünchenGermany
  2. 2.Dept. of AngiologyLudwig-Maximilians University MunichMunichGermany
  3. 3.Radiologische Klinik und PoliklinikUniversität MünchenGermany
  4. 4.Städtisches Krankenhaus München-SchwabingGermany

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