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Na+/K+-pump mutant with a slow charge translocating step

  • J.-D. Horisberger
  • F. Jaisser
  • C. Canessa
  • B. C. Rossier

Abstract

During its transport cycle the Na+/K+-pump transport 3 Na+ ions out of and to K+ ions into the cells. The translocation of the Na+ ions is associated with a net movement of charge across the membrane. Charge translocation by the Na+/K+-pump can be studied as ouabain-sensitive transient current after fast voltage perturbation under Na/Na exchange conditions (5,6). The translocation of charges has been associated with the release of Na+ ions across an external high field access channel (2,7). The structure responsible for Na+ ion translocation is not known.

Keywords

Xenopus Oocyte Forward Rate Pump Current Transport Cycle Negative Membrane Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1994

Authors and Affiliations

  • J.-D. Horisberger
    • 1
  • F. Jaisser
    • 1
  • C. Canessa
    • 1
  • B. C. Rossier
    • 1
  1. 1.Institut de Pharmacologie et de ToxicologieLausanneSwitzerland

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