Summary
Acute myocardial ischemia elicits both sympathetic and vagal reflexes. Dominant sympathetic reflexes cause an increase in heart rate, myocardial oxygen consumption and a decrease in cardiac electrical stability, thus facilitating the occurrence of malignant arrhythmias. On the other hand, recent evidence from experimental studies suggests that increased vagal activity during acute myocardial ischemia decreases the likelihood of ventricular fibrillation. In a conscious animal model of sudden cardiac death, indexes of reduced vagal tone and of impaired vagal reflexes identify dogs at higher risk for ventricular fibrillation during acute myocardial ischemia.
A further direct indication that vagal activity is indeed beneficial during myocardial ischemia derives from studies involving either neural recording of vagal activity or an interaction with the parasympathetic nervous system. The latter were achieved either electrically, by the stimulation of the vagus, or pharmacologically by muscarinic agonists and antagonists.
These experimental studies indicate that: 1) indexes of vagal tone and reflexes may help to identify subjects at higher risk for sudden cardiac death; 2) interference with the autonomic nervous system causing a shift toward a vagal dominance may represent a new strategy in the prevention of sudden cardiac death.
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References
Barber MJ, Mueller TM, Henry DP, Felten SY, Zipes DP (1983) Transmural myocardial infarction in the dog produces sympathectomy in noninfarcted myocardium. Circulation 67: 787–796
Bailey JC, Watanabe AM, Besch HR Jr, Lathrop DA (1979) Acetylcholine antagonism of the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers. Circ Res 44: 378–383
Ben-David J, Zipes DP (1988) Differential response to right and left ansae subclaviae stimulation of early afterdepolarizations and ventricular tachycardia induced by cesium in dogs. Circulation 78: 1241–1250
Benfey BG, Elfellah MS, Ogilvie RI, Varma DR (1984) Antiarrhythmic effects of prazosin and propranolol during coronary artery occlusion and reperfusion in dogs and pig’s. Br J Pharmacol 82: 717–725
Billman GE, Schwartz PJ, Stone HL (1982) Baroreceptor reflex control of heart rate: A predictor of sudden cardiac death. Circulation 66: 874–880
Blair RW, Shimizu T, Bishop VS (1980) The role of vagal afferents in the reflex control of left ventricular refractory period in the cat. Circ Res 46: 378–386
Bolli R, Brandon TA, Fischer DJ, Taylor AA, Miller RR (1982) Alpha-adrenergic blockade does not prevent arrhythmias during coronary occlusion and reperfusion in the dog. Clin Res 30: 173A.
Cerati D, Schwartz PJ (1991) Single cardiac vagal fiber activity, acute myocardial ischemia, and risk for sudden death. Circ Res 69: 1389–1401
Chadda KD, Banka VS, Helfant RH (1974) Rate dependent ventricular ectopia following acute coronary occlusion. Circulation 49: 654–659
Corr PB, Gillis RA (1974) Role of the vagus nerves in the cardiovascular changes induced by coronary occlusion. Circulation 49: 86–97
Corr PB, Gillis RA (1975) Effect of autonomic neural influences on the cardiovascular changes induced by coronary occlusion. Am Heart J 89: 766–774
Davey MJ (1980) Relevant features of the pharmacology of prazosin. J Cardiovasc Pharmacol 2: 5287–5301
De Ferrari GM, Vanoli E, Stramba-Badiale M, Hull SS Jr, Foreman RD, Schwartz PJ (1991) Vagal reflexes and survival during acute myocardial ischemia in conscious dogs with healed myocardial infarction. Am J Physiol 261: H63 - H69
De Ferrari GM, Vanoli E, Curcuruto P, Tommasini G, Schwartz PJ (1992) Prevention of life-threatening arrhythmias by pharmacologic stimulation of the muscarinic receptors with oxotremorine. Am Heart J 124: 883–890
De Ferrari GM, Salvati P, Grossoni M, Ukmar G, Vaga L, Patrono C, Schwartz PJ (1993) Pharmacologic modulation of the autonomic nervous system in the prevention of sudden cardiac death. J Am Coll Cardiol July 22: 283–290
De Ferrari GM, Mantica M, Vanoli E, Hull SS Jr, Schwartz PJ (1993) Scopolamine increases vagal tone and vagal reflexes in patients after myocardial infarction. J Am Coll Cardiol 22: 1327–1334
De Ferrari GM, Zaza A (1994) Drugs acting on cholinergic receptors. In: Cardiovascular Pharmacology and Therapeutics ( Singh BN, Dzau VJ, Van Houtten P, Woosley RL, Eds.). Churchill Livingstone, New York pp. 125–144
Einbrodt (1859) Ueber Herzreizung and ihr Verhaeltnis zum Blutdruck. Akademie der Wissenschaften (Vienna). Sitzungberichte 38: 345
Feigl EO (1967) Sympathetic control of coronary circulation. Circ Res 20: 262–271
Fleming JW, Watanabe AM (1986) Biochemical mechanisms of parasympathetic regulation of cardiac function. In Fozzard HA, Haber E, Katz AM, Morgan HE, eds. The heart and cardiovascular system. Raven Press, New York, pp. 1679–1688
Garrey WE (1908) Some effects of cardiac nerves upon ventricular fibrillation. Am J Physiol 21: 283
Gilman AG (1984) G proteins and dual control of adenylate cyclase. Cell 36: 577–579
Gnecchi Ruscone T, Lombardi F, Malfatto G, Malliani A (1987) Attenuation of baroreceptive mechanisms by cardiovascular sympathetic afferent fibers. Am J Physiol 253: H787 - H791
Goldstein RE, Karsh RB, Smith ER, Orlando M, Norman D, Farnham G, Redwood DR, Epstein SE (1973) Influence of atropine and of vagally mediated bradycardia on the occurrence of ventricular arrhythmias following acute coronary occlusion in closed-chest dogs. Circulation 47: 1180–1190
Goldberg RJ (1989) Declining out-of-hospital sudden coronary death rates: Additional pieces of the epidemiologic puzzle. Circulation 79: 1369–1373
Han J, Millet D, Chizzonitti B, Moe GK (1966) Temporal dispersion of recovery of. excitability in atrium and ventricle as a function of heart rate. Am Heart J 71: 481–487
Hering HE (1901) Die Myoerethischen Unregelmaessigkeiten des Herzens. Prager Medizinische Wochenschrift 26: 7
Hull SS Jr., Evans AR, Vanoli E, Adamson PB, Stramba-Badiale M, Albert DE, Foreman RD, Schwartz PJ (1990) Heart rate variability before and after myocardial infarction in conscious dogs at high and low risk of sudden death. J Am Coll Cardiol 16: 978–985
Janse MJ, Schwartz PJ, Wilms-Schopman F, Peters R, Durrer D (1985) Effects of unilateral stellate ganglion stimulation and ablation on electrophysiological changes induced by acute myocardial ischemia in dogs. Circulation 72: 585–595
Kent KM, Smith ER, Redwood DR, Epstein SE (1973) Electrical stability of acutely ischemic myocardium: influences of heart rate and vagal stimulation. Circulation 47: 291–298
Kliks BR, Burgess MJ, Abildskov JA (1975) Influence of sympathetic tone on ventricular fibrillation threshold during experimental coronary occlusion. Am J Cardiol 36: 45–49
Kolman BS, Verrier RL, Lown B (1976) The effect of vagus nerve stimulation upon vulnerability of the canine ventricle: Role of the sympathetic parasympathetic interactions. Circulation 52: 578–585
La Rovere MT, Specchia G, Mortara A, Schwartz PJ (1988) Baroreflex sensitivity, clinical correlates and cardiovascular mortality among patients with a first myocardial infarction. A prospective study. Circulation 78: 816–824
Levy MN, Blattberg B (1976) Effect of vagal stimulation on the overflow of norepinephrine into the coronary sinus during cardiac sympathetic nerve stimulation in the dog. Circ Res 38: 81–85
Litovsky SH, Antzelevitch C (1990) Difference in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium. Circ Res 67: 615–627
Löffelholz K, Muscholl E (1969) A mùscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation. Naunyn Schmiedebergs Arch Pharmacol 265: 1–15
Lombardi F, Casalone C, Della Bella P, Malfatto G, Pagani M, Malliani A (1984) Global versus regional myocardial ischemia: differences in cardiovascular and sympathetic responses in cats. Cardiovasc Res 18: 14–23
Lown B, Fakhro AM, Hood WB, Thorn GW (1967) The coronary care unit. JAMA 199: 188–198.
Malliani A, Schwartz PJ, Zanchetti A (1969) A sympathetic reflex elicited by experimental coronary occlusion. Am J Physiol 217: 703–709
Malliani A, Recordati G, Schwartz PJ (1973) Nervous activity of afferent cardiac sympathetic fibers with atrial and ventricular endings. J Physiol (London) 229: 457–469
Maroko PR, Kjekshus JK, Sobel BE, Watanabe T, Covell JW, Ross J Jr., Braunwald E (1971) Factors influencing infarct size following experimental coronary artery occlusions. Circulation 43: 67–74
Martins JB, Zipes DP (1980) Effects of sympathetic and vagal nerves on recovery properties of the endocardium and epicardium of the canine left ventricle. Circ Res 46: 100–110
Mohrman DE, Feigl EO (1978) Competition between sympathetic vasodilation in the canine coronary circulation. Circ Res 42: 79–86
Myers RW, Pearlman AS, Hyman RM, Goldstein RA, Kent KM, Goldstein RE, Epstein SE (1974) Beneficial effects of vagal stimulation and bradycardia during experimental acute myocardial ischemia. Circulation 49: 943–947
Pandey RC, Srivastava RD, Bathnagar VN (1979) Effect of unilateral stellate ganglion blockade and stimulation on experimental arrhythmias. Int J Physiol Pharmacol 23: 305–314
Priori SG, Zuanetti G, Schwartz PJ (1988) Ventricular fibrillation induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity: Effect of Nifedipine. Am Heart J 116: 37–45
Prystowsky EN, Jackman WM, Rinkenberger RL, Heger JJ, Zipes DP (1981) Effect of autonomic blockade on ventricular refractoriness and atrioventricular nodal conduction in humans. Evidence supporting a direct cholinergic action on ventricular muscle refractoriness. Circ Res 49: 511–518
Recordati G, Schwartz PJ, Pagani M, Malliani A, Brown AM (1971) Activation of cardiac vagal receptors during myocardial ischemia. Experientia 27: 1423–1424
Redwood DR, Smith ER, Epstein SE (1972) Coronary artery occlusion in the conscious dog: Effects of alterations in heart rate and arterial pressure on the degree of myocardial ischemia. Circulation 46: 323–332
Scherf D (1929) Untersuchungen ueber die Entstehungweise der Extrasystolen and der extrasystolischen Allorhythmien. Z Exp Med 65: 198
Schwartz PJ, Pagani M, Lombardi F, Malliani A, Brown AM (1973) A cardiocardiac sympatho-vagal reflex in the cat. Circ Res 32: 215–220
Schwartz PJ, Foreman RD, Stone HL, Brown AM, (1976) Effect of dorsal root section on the arrhythmias associated with coronary occlusion. Am J Physiol 231: 923–928
Schwartz PJ, Stone HL, Brown AM (1976) Effects of unilateral stellate ganglion blockade on the arrhythmias associated with coronary occlusion. Am Heart J 92: 589–599
Schwartz PJ, Snebold NG, Brown AM (1976) Effects of unilateral cardiac sympathetic denervation on the ventricular fibrillation threshold. Am J Cardiol 37: 1034–1041
Schwartz PJ, Stone HL (1977) Tonic influence of the sympathetic nervous system on myocardial reactive hyperemia and on coronary blood flow distribution. Circ Res 41: 51–58
Schwartz PJ, Vanoli E (1981) Cardiac arrhythmias elicited by interaction between acute myocardial ischemia and sympathetic hyperactivity: A new experimental model for the study of antiarrhythmic drugs. J Cardiovasc Pharmacol 3: 1251–1259
Schwartz PJ, Billman GE, Stone HL (1984) Autonomic mechanisms in ventricular fibrillation induced by myocardial ischemia during exercise in dogs with healed myocardial infarction. An experimental preparation for sudden cardiac death. Circulation 69: 790–800
Schwartz PJ, Vanoli E, Zaza A, Zuanetti G (1985) The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. Am Heart J 109: 937–948
Schwartz PJ, Stone HL (1985) The analysis and modulation of autonomic reflexes in the prediction and prevention of sudden death. In: Cardiac Electrophysiology and arrhythmias: ( Zipes DP, Jalife J, Eds.) Grune and Stratton, New York, pp. 165–176
Schwartz PJ, Priori SG, Vanoli E, Zaza A, Zuanetti G (1986) Efficacy of diltiazem in two experimental models of sudden death. J Am Coll Cardiol 8: 661–668
Schwartz PJ (1987) Manipulation of the autonomic nervous system in the prevention of sudden cardiac death. In: Twenty years of cardiac electrophysiology. ( Brugada P, Wellens HJJ, Eds.) Futura Publishing Co., Mount Kisco, NY, pp. 741–765
Schwartz Pi, Vanoli E, Stramba-Badiale M, De Ferrari GM, Billman GE, Foreman RD (1988) Autonomic mechanisms and sudden death. New insight from the analysis of baroreceptor reflexes in conscious dogs with and without a myocardial infarction. Circulation 78: 969–979
Schwartz PJ, Priori SG (1990) Sympathetic nervous system and cardiac arrhythmias. In: Cardiac electrophysiology. From cell to bedside. ( Zipes DP, Jalife J, Eds.) WB Sanders Co., Philadelphia, PA, pp. 330–343
Schwartz Pi, La Rovere MT, Vanoli E (1992) Autonomic nervous system and sudden cardiac death. Circulation 85 ( Suppl. I): 177–191
Sheridan DJ, Penkoske PA, Sobel BE, Corr PB (1980) Alpha-adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats. J Clin Invest 65: 161–171
Smeets JLRM, Allessie MA, Lammers WJEP, Bonke FIM, Hollen J (1986) The wavelength of the cardiac impulse and reentrant arrhythmias in isolated rabbit atrium: The role of heart rate, autonomic transmitters, temperature and potassium. Circ Res 58: 96–108
Thames MD, Klopfenstein HS, Abboud FM, Mark AL, Walker JL (1978) Preferential distribution of inhibitory cardiac receptors with vagal afferents to the inferoposterior wall of the left ventricle activated during coronary occlusion in the dog. Circ Res 43: 512–519
Thoren P (1978) Vagal reflexes elicited by left ventricular C-fibers during myocardial ischemia in cats. In: Neural mechanisms in cardiac arrhythmias ( Schwartz PJ, Brown AM, Malliani A, Zanchetti A, Eds.) Raven Press, New York, pp. 179–190
Vanoli E, De Ferrari GM, Stramba-Badiale M, Hull SS Jr, Foreman RD, Schwartz Pi (1991) Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. Circ Res 68: 1471–1481
Vanoli E, Hull SS Jr., Foreman RD, Ferrari A, Schwartz PJ (1994) alphas adrenergic blockade and sudden cardiac death. J Cardiovasc Electrophysiol 5: 76–83
Wit AL, Rosen MR (1986) Afterdepolarizations and triggered activity. In: Fozzard HA, Haber E, Jennings RB et al. (eds.): The heart and the cardiovascular system. New York, Raven Press, pp. 1449–1490
Yusuf S, Teo KK (1991) Approaches to prevention of sudden death: need for fundamental reevaluation. J Cardiovasc Electrophysiol 2 (Suppl): S233 - S239
Zuanetti G, De Ferrari GM, Priori SG, Schwartz PJ (1987) Protective effect of vagal stimulation on reperfusion arrhythmias in cats. Circ Res 61: 429–435
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© 1994 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
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De Ferrari, G.M., Schwartz, P.J. (1994). Autonomic nervous system, myocardial ischemia, and malignant ventricular arrhythmias: Experimental findings. In: Zehender, M., Meinertz, T., Just, H. (eds) Myocardial Ischemia and Arrhythmia. Steinkopff. https://doi.org/10.1007/978-3-642-72505-0_16
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