Summary
During the last decade, angiotensin-converting enzyme inhibitors (ACE-I) have become cornerstones in the treatment of clinical congestive heart failure, there is convincing evidence that they improve survival and that, in this respect, they are superior to ordinary vasodilators. ACE-I administration also improves New York Heart Association functional class and the left-ventricular function. But their long-term effects on exercise tolerance and quality of life appear modest. During prolonged administration to patients with ischemic left-ventricular dysfunction, ACE-I also significantly reduce the incidence of new ischemic events (myocardial infarction, unstable angina).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Araki T, Shimizu M, Sugihara N, Takeda R (1992) Effect of angiotensin converting enzyme inhibitor on myocardial collagen metabolism in cardiomyopathic hamsters. J Moll Cell Cardiol 24: S56
Bussman WD, Störger H, Hadler N (1987) Long-term treatment of severe chronic heart failure with Captopril: a double-blind, randomized, placebo-controlled, long-term study. J Cardiovasc Pharmacol 9: S50–S60
Captopril Multicenter Research Group (1983) A placebo-controlled trial of Captopril in refractory chronic congestive heart failure. J Am Coll Cardiol 2: 755–763
Chalmers JP, West MJ, Cyran J (1987) Placebo-controlled study of lisinopril in congestive heart failure: a multicenter study. J Cardiovasc Pharmacol 9: S89–S97
Cleland JG F, Dargie HJ, Ball SG (1985) Effects of enalapril in heart failure: a double-blind study of effects in exercise performance, renal function, hormones, and metabolic state. Br Heart J 54: 305–312
Cohn JN, Johnson G, Ziesche S, Cobb F, Francis G, Tristani F et al. (1991) A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 325: 303–310
Held P, Swedberg K (1992) ACE-inhibitors in the treatment of heart failure. In: Barnett D, Francis G, Pouleur H (eds) Heart failure: newer therapeutics. Marcel Dekker, Inc. (in press)
Hirakata H, Fouad-Tarazi FM, Bumpus FM, Khosla M, Healy B, Husain A et al. (1990) Angiotensins and the failing heart. Enhanced positive inotropic responce to angiotensin I in cardiomyopathic hamster heart in the presence of Captopril. Circ Res 66: 891–899
Konstam MA, Rousseau MF, Kronenberg MW, Udelson JE, Melin J, Stewart D et al. (1992) Effects of the angiotensin converting enzyme inhibitor enalapril, on the long-term progression of left ventricular dysfunction in patients with heart failure. Circulation 86: 431–438
McGrath BP, Arnolda L, Matthews PG (1985) Controlled trial of enalapril in congestive cardiac failure. Br Heart J 54: 405–414
Pacher R, Globits S, Bergler-Klein J, Kratochwill C, Stefenelli T, Baumgartner W et al. (1992) Clinical and neurohumoral response of patients with severe congestive heart failure treated with two different captopril dosages. J Am Coll Cardiol 19: 317
Pfeffer MA, Braunwald E (1990) Ventricular remodeling after myocardial infarction Experimental observations and clinical implications. Circulation 81: 1161–1172
Pouleur H, Konstam MA, van Eyll C, Melin J, Gallagher P, Yusuf S, Rousseau MF, for the SOLVD Investigators (1992) Long-term effects of enalapril on left ventricular diastolic properties: evidence for “reversed remodeling”. Circulation 86: 1–120
Remes J, Nikander P, Rehnberg S (1986) Enalapril in chronic heart failure, a double-blind placebo-controlled study. Ann Clin Res 18: 124–128
Sharpe DN, Murphy J, Coxon R, Hannan SF (1984) Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study. Circulation 70: 271–278
Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen and CONSENUS Trial Study Group (1990) Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. Circulation 82: 1730–1736
The captopril-digoxin multicenter research group (1988) Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA 259: 539 - 544
The CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 316: 1429 - 1435
The SOLVD Investigators (1990) Studies of left ventricular dysfunction (SOLVD) — Rationale, design and methods: two trials that evaluate the effect of enalapril in patients with reduced ejection fraction. Am J Cardiol 66: 315–322
The SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 325: 293–302
The SOLVD Investigator (1992) Effects of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fraction. N Engl J Med 327: 685–691
Urata H, Healy B, Stewart RW, Bumpus FM, Husain A (1990) Angiotensin II-forming pathways in normal and failing human hearts. Circ Res 66: 883–890
Vagelos R, Yee G, Boyle M, Moore C, Prikaszky L, Willson K et al. (1992) Failure of low but not high dose chronic enalapril therapy to suppress serum angiotensin converting enzyme ( ACE) activity in heart failure. J Am Coll Cardiol 19: 145
Weber KT, Brilla CG (1991) Pathological hypertrophy and cardiac interstitium. Circulation 83 (6): 1849–1865
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
About this chapter
Cite this chapter
Pouleur, H. (1993). Angiotensin-converting enzyme inhibitors in the treatment of clinical heart failure. In: Grobecker, H., Heusch, G., Strauer, B.E. (eds) Angiotensin and the Heart. Steinkopff. https://doi.org/10.1007/978-3-642-72497-8_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-72497-8_14
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-0936-8
Online ISBN: 978-3-642-72497-8
eBook Packages: Springer Book Archive