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Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine

  • John P. Cooke
  • J. Dzau
  • A. Creager
Conference paper

Summary

Hypercholesterolemia attenuates endothelium-dependent vasorelaxation and augments the responses to vasoconstrictor agents. Both effects are largely due to a reduction in the release of endothelium-derived relaxing factor. Since endothelium-derived relaxing factor is now known to be nitric oxide derived from the metabolism of L-arginine, we hypothesized that the abnormal vascular response in hypercholesterolemia could be corrected by supplying the precursor to EDRF, L-arginine. In a series of studies, we have found that conduit and resistance vessels of hypercholesterolemic animals demonstrate endothelial dysfunction which is reversed after exposure to high concentrations of exogenous L-arginine. The experiments suggest that hypercholesterolemia induces a reversible dysfunction of arginine availability or metabolism.

Key words

Endothelium hypercholesterolemia endothelium-derived relaxing factor arginine 

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1991

Authors and Affiliations

  • John P. Cooke
    • 1
  • J. Dzau
    • 1
  • A. Creager
    • 2
  1. 1.Falk Cardiovascular Research CenterStanford University Medical CenterStanfordUSA
  2. 2.Division of Vascular MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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